The Center for Genetics and Complex Traits (CGACT) is a Type I Center of the Center for Clinical Epidemiology and Biostatistics. The theme of CGACT is to develop and apply epidemiological and statistical approaches that integrate knowledge from the human genome, basic molecular and cellular biology, biomedical informatics, behavioral science, bioethics and the clinical sciences to understand complex human disease traits.
These methods will be applied to study etiology and outcomes associated with cancer, sleep disorders, psychiatric disorders including addiction, obesity, diabetes, autoimmune disorders, asthma, cardiovascular disease, and others.
Cool New Science
- Hakonarson H, Grant SFA, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Chiavacci RM, Stanley CA, Kirsch SE, Monos DS, Devoto M, Qu HQ, Polychronakos C: A genome-wide association study identifies KIAA0350 as a novel type 1 diabetes gene. Nature 448:591-594, 2007.
- Lantieri F, Rydbeck H, Griseri P, Ceccherini I, Devoto M: Incorporating prior biological information in linkage studies increases power and limits multiple testing. BMC Proceedings 1 (Suppl. 1):S89, 2007
- Kimmel SE, Christie J, Kealey C, Chen Z, Price M, Thorn CF, Brensinger CM, Newcomb CW, Whitehead AS. Apolipoprotein E (APOE) Genotype and Warfarin Dosing among Caucasians and African Americans [In Press, The Pharmacogenomics Journal]. 2007 Feb 27
- Schelleman H, Chen Z, Kealey C, Whitehead AS, Christie J, Price M, Brensinger CM, Newcomb CW, Thorn CF, Samaha FF, Kimmel SE. Warfarin Response and Vitamin K Epoxide Reductase Complex 1 in African Americans and Caucasians. Clinical Pharmacology and Therapeutics. 2007;81:742-7
- Mushlin R.A., Kershenbaum A, Gallagher S.T., Rebbeck T.R. A graph-theoretical approach for pattern discovery in epidemiological research.
IBM Systems Journal.
2007 January; 46(1)
