Sean Hennessy, PharmD, PhD

Office Location803, Blockley Hall
Office Phone215-898-9112

Faculty Information

CCEB AppointmentSenior Scholar, Epidemiology
Primary Faculty AppointmentAssociate Professor of Epidemiology, University of Pennsylvania Perelman SOM

Additional Positions

Associate Professor of Pharmacology, Department of Pharmacology

Director, Center for Pharmacoepidemiology Research and Training (CPeRT)

Director of Ambulatory Drug Use and Effects, University of Pennsylvania Medical Center

Senior Fellow, Leonard Davis Institute of Health Economics

Fellow, Institute on Aging

Regional Editor for the Americas, Pharmacoepidemiology and Drug Safety

Research Statement

Dr. Hennessy’s primary field of interest is pharmacoepidemiology, which is the study of the use and effects of medications in populations. Within pharmacoepidemiology, he has a particular interest in studying the clinical importance of drug-drug interactions. Dr. Hennessy’s research has been funded by the Agency for Healthcare Research and Quality (AHRQ), the National Institutes of Health (NIH), pharmaceutical companies, and private foundations. He is currently leading a NIH-funded study on the clinical importance of drug-drug interactions. He is the principal investigator of Penn’s AHRQ-funded “Developing Evidence to Inform Decisions About Effectiveness” (DEcIDE) center, and of Penn's Center in the FDA-funded Scientific Program to Support Epidemiology Investigations.

In addition to his research, Dr. Hennessy teaches clinical epidemiology to medical and graduate students, and is active in promoting evidence based practice at Penn, directing its Ambulatory Drug Use and Effects Program, and serving on its Pharmacy and Therapeutics Committee. Dr. Hennessy’s clinical program has received two Quality and Safety Awards from the University of Pennsylvania Health System. Dr. Hennessy received the 2005 Young Alumnus Award from the University of the Sciences in Philadelphia, and the 2007 Lean I Goldberg Young Investigator Award from Pharmacology and Therapeutics.

Courses Taught

EPID 666 - Pharmacoepidemiology Research

Selected Publications

Wade KC, Ellenberg JH, Grosser T, Brensinger CM, Kimmel SE, Hennessy S.: Exogenous estrogen does not attenuate the association between rofecoxib and myocardial infarction in perimenopausal women. Journal of Cardiovascular Pharmacology 57(2): 194-200, 2011.

Schelleman H, Pollard JR, Newcomb C, Markowitz CE, Bilker WB, Leonard MB, Hennessy S.: Exposure to CYP3A4 inducing and CYP3A4 non-inducing antiepileptic agents and the risk of fractures.Pharmacoepidemiology and Drug Safety 20: 619-25, 2011.

Schelleman H, Brensinger CW, Bilker WB, Hennessy S. : Antidepressant-warfarin interaction and associated gastrointestinal bleeding risk in a case-control study. PLoS ONE 6(6): e21447, 2011 Notes: doi:10.1371/journal.pone.0021447.

Schelleman H, Bilker WB, Strom BL, Kimmel SE, Newcomb C, Guevara JP, Daniel GW, Cziraky MJ, Hennessy S.: Cardiovascular events and death in children exposed and unexposed to ADHD agents. Pediatrics 127(6): 1102-10, 2011.

Leonard CE, Bilker WB, Newcomb C, Kimmel SE, Hennessy S. : Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia. Pharmacoepidemiology & Drug Safety 20: 903-13, 2011.

Hennessy S, Leonard CE, Localio AR, Cohen A, Yang W, Cheung L, Strom BL, Feldman HI. : Prescriber adherence to pharmacokinetic monitoring service recommendations for aminoglycoside dosing and the risk of acute kidney injury. International Journal of Clinical Pharmacology and Therapeutics 49(9): 536-44, 2011.

Schellman H, Bilker WB, Brensinger CM, Wan F, Hennessy S.: Anti-infectives and risk of severe hypoglycemia in users of glipizide and glyburide. Clinical Pharmacology and Therapeutics 88: 214-22, 2010.

Strom BL, Schinnar R, Bilker W, Hennessy S, Leonard CE, Pifer E.: Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID–warfarin co-prescribing as a test case. Journal of the American Medical Informatics Association 17: 411-15, 2010.

Hennessy S, Leonard CE, Freeman CP, Deo R, Newcomb C, Kimmel SE, Strom BL, Bilker WB. : Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data. Pharmacoepidemiology and Drug Safety 19: 555-62, 2010.

Li P, Blum MA, Von Feldt J, Hennessy S, Doshi JA: Adherence, discontinuation, and switching of biologic therapies in medicaid enrollees with rheumatoid arthritis Value in Health 13(6): 805-12, 2010.

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