Theoklis Zaoutis, MD, MSCE

Office LocationSuite 1527, 3535 Market
Office Phone267-426-5570

Faculty Information

CCEB AppointmentSenior Scholar, Epidemiology
Primary Faculty AppointmentProfessor of Pediatrics at CHOP, Division of Infectious Diseases, University of Pennsylvania Perelman SOM/CHOP
DBE AppointmentProfessor of Epidemiology

Additional Positions

Director, Antimicrobial Stewardship Program, The Children's Hospital of Philadelphia

Associate Hospital Epidemiologist, The Children's Hospital of Philadelphia

Director, Fellowship Training Program in Pediatric Infectious Diseases, The Children's Hospital of Philadelphia

Research Statement

Dr. Zaoutis' research focuses on healthcare-acquired infections and antibiotic resistance. He is investigating the epidemiology of fungal infections in children with a specific focus on how antibiotics may affect the risk of developing candidemia. Furthermore, he is investigating the emergence of extended-spectrum beta lactamase producing organisms and community-acquired methcillin-resistant S. aureus in children. Finally, Dr. Zaoutis is studying patterns of antibiotic use in hospitalized children and the potential impact of antimicrobial stewardship programs on antibiotic utilization.

Selected Publications

Zaoutis TE, Greves HM, Lautenbach E, Bilker WB, Coffin SE: Risk Factors for Disseminated Candidiasis in Children with Candidemia. Pediatr Infect Dis J 2004; 23(7): 635-641.

Zaoutis TE, Goyal M, Chu J, Coffin SE, Bell LM, Nachamkin I, McGowan KL, Bilker WB, Lautenbach E: Risk Factors for and Outcomes of Bloodstream Infection Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli and Klebsiella Species in Children. Pediatrics 2005; 115(4): 942-949.

Hyle EP, Lipworth AD, Zaoutis TE, Nachamkin I, Fishman NO, Bilker WB, Mao X, Lautenbach E: Risk factors for increasing multidrug resistance among extended spectrum beta-lactamase-producing Escherichia coli and Klebsiella species. Clinical Infectious Diseases 2005; 40: 1317-24.

Hyle EP, Lipworth AD, Zaoutis TE, Nachamkin I, Bilker WB, Lautenbach E: Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing enterobacteriaceae: variability by site of infection. Arch Intern Med 2005; 165(12): 1375-80.

Zaoutis TE, Coffin SE, Chu JH, Heydon K, Zhao H, Greves HM, Walsh TJ: Risk factors for mortality in children with candidemia. Pediatric Infectious Disease Journal 2005; 24(8): 736-39.

Zaoutis TE, Foraker E, McGowan KL, Mortensen J, Campos J, Walsh TJ, Klein JD: Antifungal susceptibility of Candida spp. isolated from pediatric patients: a survey of four children's hospitals. Diagnostic Microbiology and Infectious Diseases 2005; 52(4): 295-8.

Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ: Epidemiology and Outcome of Zygomycosis: A Review of 929 Reported Cases Clinical Infectious Diseases 2005; 41: 634-53.

Keren R, Zaoutis TE, Bridges CB, Herrera G, Watson B, Wheeler A, Licht DJ, Luan XQ, Coffin SE: Neurologic and Neuromuscular Diseases as Risk Factors for Respiratory Failure in Children Hospitalized with Influenza Infection. JAMA 2005; 294(17): 2188-94.

Zaoutis TE, Argon J, Chu J, Berlin JB, Feudtner, C: The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the US: A propensity analysis. Clinical Infectious Diseases 2005; 41: 1232-9.

Chu JH, Feudtner C, Heydon K, Walsh T, Zaoutis TE: Hospitalizations with Endemic Mycoses: A Population-Based National Study. Clinical Infectious Diseases 2006; 42: 822-5.

Ruebner R, Keren R, Coffin S, Chu J, Horn D, Zaoutis TE: Complications of central venous catheters used for the treatment of acute hematogeneous osteomyelitis. Pediatrics 2006; 117: 1210-15.

Zaoutis TE, Heydon K, Chu JH, Walsh T, Steinbach W: Epidemiology, Outcomes, and Costs of Invasive Aspergillosis in Immunocpmpromised Children in the United States, 2000. Pediatrics 2006; 117(4): e711-16.

Zaoutis TE, Toltzis P, Chu J, Abrams T, Dul M, Kim J, Mcgowan KL, Coffin SE: Clinical and molecular epidemiology of community-acquired methicillin-resistant Staphylococcus aureus infections among children with risk factors for health-care associated infection: 2001-2003. Pediatr Infect Dis J 2006; 25(4): 343-348.

MacAdam H, Zaoutis TE, Gasink LB, Bilker WB, Lautenbach E: Investigating the association between antibitoic use and antibiotic resistance: impact of different methods of categorizing prior antibitoic use. International Journal of Antimicrobial Agents 2006; 28(4): 325-332.

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