Hongzhe Lee (Li), PhD

Office Location215, Blockley Hall
Office Phone215-573-5038
Personal Websitehttp://www.cceb.upenn.edu/~hli/

Faculty Information

CCEB AppointmentSenior Scholar, Biostatistics
Primary Faculty AppointmentProfessor of Biostatistics, University of Pennsylvania Perelman SOM

Research Statement

Dr. Li's research interests focus on developing statistical, probabilistic, and computational methods for genetic and g enomic data analysis, bioinformatics and computational biology. He has developed improved linkage and association analysis methods for mapping genes for complex human diseases. He has recently been developing statistical methods for analysis of microarray time course gene expression data, methods for linking high-throughput genomic data such as microarray gene expression data and array CGH data to censored survival data and methods for inferences of genetic networks.

Dr. Li won the International Genetic Epidemiology Society's Best Paper Award in 1998 and currently is an an Associate Editor of JASA Theory and Method.

Selected Publications

Seldin MF, Morii T, Collins-Schramm HE, Chima B, Kittles R, Criswell LA, Li H: Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping. Genome Research. 14(6):1076-84. Jun 2004.

Luan Y, Li H: Model-based methods for identifying periodically regulated genes based on the time course microarray gene expression data. Bioinformatics. 20:332-339. 01 Jan 2004.

Zhong X, Li H: Score tests of genetic association in the presence of linkage based on the additive genetic gamma frailty model. Biostatistics. In 5:307-327. 01 Jan 2004.

Sun W, Li H: Ascertainment-adjusted maximum likelihood estimation for the additive genetic gamma frailty models. Lifetime Data Analysis. 10:229-245. 01 Jan 2004.

Zhang C, Chen K, Seldin M, Li H: A Hidden Markov Modeling Approach for Admixture Mapping Based on Case-Control Data. Genetic Epudemiology. 27:225-239. 2004.

Li H, Luan Y: Kernel Cox regression models for linking gene expression profiles to censored survival data. Pacific Symposium on Biocomputing. 8:65-76. 2003.

Luan Y, Li H: Clustering of time-course gene expression data using a mixed-effects model with B-splines. Bioinformatics. 19:474-482. 2003.

Li H, Zhong X: Multivariate survival models induced by genetic frailties, with applications to linkage analysis. Biostatistics. 3:57-75. 2002.

Li H: The additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families. Lifetime Data Analysis. 8:315-334. 2002.

Li H, Luan Y, Hing F, Li Y: Statistical methods for analysis of time-course gene expression data. Frontiers in Bioscience. 7:a90-a98. 2002.

Zhong X, Li H: An additive genetic gamma frailty model for two-locus linkage analysis using sibship age of onset data. Statistical Applications in Genetics and Molecular Biology. 1:Articale 1. 2002.

Collins-Schramm HE, Phillips CM, Operario DJ, Lee JS, Webber JL, Hanson RL, Knowler WC, Cooper R, Li H, Seldin MF: Ethnic-difference markers for use in mapping by admixture linkage disequilibrium. American Journal of Human Genetics. 70:737-750. 2002.

Parsa A, Peden E, Lum RF, Seligman VA, Olson JL, Li H, Seldin MF, and Criswell LA,Association of angiotensin converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families. Genes and Immunity. 3:S42-S46. 2002.

Hsu L, Li H: A method for incorporating ages at onset in affected sibpair linkage studies. Human Heredity. 54:1-12. 2002.

Li H, Hong F: Cluster-Rasch models for microarray gene expression data. Genome Biology. research0031.1-0031.. 2001.

Li H: A permutation procedure for the haplotype method for identification of disease-predisposing variants. Annals of Human Genetics. 65:189-196. 2001.

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