Ebbing Lautenbach, MD, MPH, MSCE

Office Location825, Blockley Hall
Office Phone(215) 898-6977
Personal Websitehttp://www.uphs.upenn.edu/idd/Lautenbach.html

Faculty Information

CCEB AppointmentSenior Scholar, Epidemiology
Primary Faculty AppointmentProfessor of Medicine, Infectious Diseases Division, University of Pennsylvania Perelman SOM
DBE AppointmentProfessor of Epidemiology

Additional Positions

Fellow, Institute on Aging, University of Pennsylvania School of Medicine

Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine

Senior Fellow, Center for Public Health Initiatives, University of Pennsylvania School of Medicine

Associate Hospital Epidemiologist, Hospital of the University of Pennsylvania

Associate Director, Clinical Epidemiology Unit, Educational Programs

Research Statement

Dr. Lautenbach's research focuses on antibiotic use, antimicrobial resistance, outbreak investigation, and epidemiologic methods in the study of infectious diseases. This research focuses on various healthcare settings including acute care hospitals and long term care facilities. With regard to gram-positive infections, his specific focus has been on patterns of use of vancomycin, vancomycin intolerance, and the relationship of the use of this agent to the epidemiology of vancomycin-resistant enterococcal (VRE) infections. Furthermore, he is investigating the emergence of extended-spectrum beta-lactamase (ESBL) resistance among gram-negative organisms, particularly how the dissemination of this resistance mechanism responds to manipulations of hospital antimicrobial formularies. Finally, Dr. Lautenbach is studying patterns of use of the fluoroquinolone antibiotics, as well as how such use patterns affect current trends in resistance to these agents.

Courses Taught

Course Director, Critical Appraisal of the Medical Literature
Course Director, Epidemiological Research Methods in Infectious Diseases

Selected Publications

Lautenbach E, Fishman NO, Bilker WB, Castiglioni A, Metlay JP, Edelstein PH, Strom BL.: Risk factors for fluoroquinolone resistance in nosocomial Escherichia coli and Klebsiella pneumoniae infections. Archives of Internal Medicine 2002;162:2469-77

Lautenbach E, Strom BL, Bilker WB, Patel JB, Edelstein PH, Fishman NO.: Epidemiological investigation of fluoroquinolone resistance among extended-spectrum -lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae (ESBL-EK). Clinical Infectious Diseases 2001;33:1288-94

Lautenbach E, Patel JB, Bilker WB, Edelstein PH, Fishman NO.: Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes. Clinical Infectious Diseases 2001;32:1162-71

Mikanatha N, Welliver DP, Rohn DD, Julian KG, Lautenbach E: Use of the web by state and territorial health departments to promote reporting of infectious disease. JAMA 2004;291:1069-70

Hyle EP, Lipworth AD, Zaoutis TE, Nachamkin I, Bilker WB, Lautenbach E: Impact of inadequate initial antibiotic therapy on mortality in infections due to extended spectrum -lactamase-producing Enterobacteriaceae: Variability by site of infection. Archives of Internal Medicine 2005;165:1375-80

Lautenbach E, Metlay JP, Bilker WB, Edelstein PH, Fishman NO.: Association between fluoroquinolone resistance and mortality in Escherichia coli and Klebsiella pneumoniae infections: The role of inadequate empirical antimicrobial therapy. Clinical Infectious Diseases 2005;41:923-9

Gasink LB, Fishman NO, Weiner MG, Nachamkin I, Bilker WB, Lautenbach E. Fluoroquinolone-resistant Pseudomonas aeruginosa: Assessment of risk factors and clinical impact. American Journal of Medicine 2006;119:526.e19-e26

Gasink LB, Blumberg EA, Localio AR, Desai SS, Israni AK, Lautenbach E. Hepatitis C virus seropositivity and survival in heart transplant recipients. JAMA 2006;296:1843-50

Lautenbach E, Metlay JP, Weiner MG, Bilker WB, Tolomeo P, Mao X, Nachamkin I, Fishman NO. Gastrointestinal tract colonization with fluoroquinolone-resistant Escherichia coli in hospitalized patients: changes over time in risk factors for resistance. Infection Control and Hospital Epidemiology 2009;30:18-24. [PMC2883613]

Lautenbach E, Marsicano R, Tolomeo P, Heard M, Serrano S, Stieritz DD. Epidemiology of antimicrobial resistance among Gram-negative organisms recovered from patients in a multistate network of long-term care facilities. Infection Control and Hospital Epidemiology 2009:30:790-3. [PMC2768769]

Lautenbach E, Saint S, Henderson DK, Harris AD. Initial Response of Health Care Institutions to Emergence of H1N1 Influenza: Experiences, Obstacles, and Perceived Future Needs. Clinical Infectious Diseases 2010;50:523-27. [PMC2811228]

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