Daniel F. Heitjan, PhD

Office Location622, Blockley Hall
Office Phone215-573-7328
Emaildheitjan@mail.med.upenn.edu
Personal Websitehttp://www.cceb.upenn.edu/heitjan/index.html

Faculty Information

CCEB AppointmentSenior Scholar, Biostatistics
Primary Faculty AppointmentProfessor of Biostatistics, University of Pennsylvania Perelman SOM

Additional Positions

Professor of Statistics, Wharton School, University of Pennsylvania

Director of the Biostatistics Resource, Abramson Cancer Center

Chair of the Graduate Group in Epidemiology & Biostatistics

Research Statement

Dr. Heitjan's research focuses broadly on statistical methods for the design and analysis of medical studies. He has made important contributions in the areas of incomplete data, the design and analysis of clinical trials, the analysis of longitudinal studies, and more recently the analysis of data in health economics. He has held NIH grants to develop methodology for outcomes research studies linked to clinical trials and to develop methods for diagnosing sensitivity to nonignorability in studies with missing data. Currently he holds an R01 grant from the NCI to study statistical methods in smoking cessation research. His collaborative work has been predominantly in cancer (for seven years he directed the biostatistics core resource in the Columbia University cancer center) and in cardiac surgery (he was lead statistician for the REMATCH trial).

Dr. Heitjan serves on the editorial boards of JNCI and Statistics in Biopharmaceutical Research and was previously on the editorial boards of JASA and Statistics in Medicine. He won the 1994 CDC/ATSDR Statistics Award (with co-author Phil Smith) and was the 1994-1995 Stanley Schor Scholar at Merck Research Labs. He was elected a Fellow of the American Statistical Association in 1997 and was overall Program Chair of the 2005 Joint Statistical Meetings. He has been elected Chair of the ASA Biometrics Section (the largest section in the ASA) for 2009.

Selected Publications


  1. Guo, Mengye and Heitjan, Daniel F. (2010). Multiplicity-calibrated Bayesian hypothesis tests. Biostatistics 11, 473-483.
  2. Li, Yimei, Wileyto, E. Paul and Heitjan, Daniel F. (2010). Modeling smoking cessation data with alternating states and a cure fraction using frailty models. Statistics in Medicine 29, 627-638.
  3. Griffith, Sandra D., Shiffman, Saul and Heitjan, Daniel F. (2009). A method comparison study of time-line follow-back and ecological momentary assessment of daily cigarette consumption. Nicotine & Tobacco Research 11, 1368-1373, doi: 10.1093/ntr/ntp150.
  4. Heitjan, Daniel F. (2009). Review of Missing Data in Longitudinal Studies: Strategies for Bayesian Modeling and Sensitivity Analysis by Michael J. Daniels and Joseph W. Hogan. Biometrics 65, 328.
  5. Xie, Hui and Heitjan, Daniel F. (2009). Local sensitivity to nonignorability: Dependence on the assumed dropout mechanism. Statistics in Biopharmaceutical Research 1, 243-257.
  6. Heitjan, Daniel F., Asch, David A., Rukstalis, Margaret, Patterson, Freda and Lerman, Caryn (2008). Cost-effectiveness of pharmacogenetic testing to tailor smoking cessation treatment. The Pharmacogenomics Journal 8, 391-399.
  7. Heitjan, Daniel F., Guo, Mengye, Ray, Riju, Wileyto, E. Paul, Epstein, Leonard H. and Lerman, Caryn (2008). Identification of pharmacogenetic markers in smoking cessation therapy. The American Journal of Medical Genetics: Neuropsychiatric Genetics 147B, 712-719.
  8. Wang, Hao and Heitjan, Daniel F. (2008). Modeling heaping in self-reported cigarette counts. Statistics in Medicine 27, 3789-3804.
  9. Ying, Gui-shuang and Heitjan, Daniel F. (2008). Weibull prediction of event times in randomized clinical trials. Pharmaceutical Statistics 7, 107-120.
  10. Donovan, J. Mark, Elliott, Michael R. and Heitjan, Daniel F. (2007). Predicting event times in clinical trials when randomization is masked and blocked. Clinical Trials 4, 481-490.
  11. Mitra, Nandita and Heitjan, Daniel F. (2007). Sensitivity of the hazard ratio to nonignorable treatment assignment in an observational study. Statistics in Medicine 26, 1398-1414.
  12. Zhang, Jiameng and Heitjan, Daniel F. (2007). Impact of nonignorable coarsening on Bayesian inference. Biostatistics 8, 722-743.
  13. Donovan, J. Mark, Elliott, Michael R. and Heitjan, Daniel F. (2006). Predicting event times in clinical trials when treatment arm is masked. Journal of Biopharmaceutical Statistics 16, 343-356.
  14. Li, Huiling and Heitjan, Daniel F. (2006). A pattern-mixture model for the analysis of censored quality-of-life data. Statistics in Medicine 25, 1533-1546.
  15. Zhang, Jiameng and Heitjan, Daniel F. (2006). A simple sensitivity analysis tool for nonignorable coarsening: Application to dependent censoring. Biometrics 62, 1260-1268.
  16. Gelman, Andrew, Van Mechelen, Iven, Verbeke, Geert, Heitjan, Daniel F. and Meulders, Michel (2005). Multiple imputation for model checking: Completed-data plots with missing and latent data. Biometrics 61, 74-85.
  17. Ma, Guoguang, Troxel, Andrea B. and Heitjan, Daniel F. (2005). An index of local sensitivity to nonignorable dropout in longitudinal modeling. Statistics in Medicine 24, 2129-2150.
  18. Zhang, Jiameng and Heitjan, Daniel F. (2005). Nonignorable censoring in randomized clinical trials. Clinical Trials 2, 488-496.
  19. Heitjan, Daniel F., Kim, Clara Yuri and Li, Huiling (2004). Bayesian estimation of cost-effectiveness from censored data. Statistics in Medicine 23, 1297-1309.
  20. Heitjan, Daniel F. and Li, Huiling (2004). Bayesian estimation of cost-effectiveness: An importance-sampling approach. Health Economics 13, 191-198.
  21. Troxel, Andrea, Ma, Guoguang and Heitjan, Daniel F. (2004). An index of local sensitivity to nonignorability. Statistica Sinica 14, 1221-1237.
  22. Xie, Hui and Heitjan, Daniel F. (2004). Sensitivity analysis of causal inference in a clinical trial subject to crossover. Clinical Trials 1, 21-30.
  23. Ying, Gui-Shuang, Heitjan, Daniel F. and Chen, Tai-Tsang (2004). Nonparametric prediction of analysis times in randomized clinical trials. Clinical Trials 1, 352-361.
  24. Bagiella, Emilia and Heitjan, Daniel F. (2001). Predicting analysis times in randomized clinical trials. Statistics in Medicine 20, 2055-2063.
  25. Rose, Eric A., Gelijns, Annetine C., Moskowitz, Alan J., Heitjan, Daniel F., Stevenson, Lynne W., Dembitsky, Walter, Long, James W., Ascheim, Deborah D., Tierney, Anita R., Levitan, Ronald G., Watson, John T. and Meier, Paul for the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group (2001). Long-term use of a left ventricular assist device for end-stage heart failure. New England Journal of Medicine 345, 1435-1443. (Accompanying editorial: Jessup, Mariell (2001). Mechanical cardiac-support devices-dreams and devilish details. New England Journal of Medicine 345, 1490-1493.)
  26. Heitjan, Daniel F. (2000). Fieller's method and net health benefits. Health Economics 9, 327-335.
  27. Heitjan, Daniel F. (1999). Causal inference in a clinical trial: A comparative example. Controlled Clinical Trials 20, 309-318.
  28. Heitjan, Daniel F. (1999). Ignorability and bias in clinical trials. Statistics in Medicine 18, 2421-2434.
  29. Heitjan, Daniel F., Moskowitz, Alan J. and Whang, William (1999). Bayesian estimation of cost-effectiveness ratios from clinical trials. Health Economics 8, 191-201.
  30. Heitjan, Daniel F., Moskowitz, Alan J. and Whang, William (1999). Problems with interval estimation of the incremental cost-effectiveness ratio. Medical Decision Making 19, 9-15. (Accompanying editorial: Stinnett, Aaron A. (1999). Is it really so bad to be unambiguously inefficient? The role of dominance in stochastic cost-effectiveness analysis. Medical Decision Making 19, 102-103.)
  31. Heitjan, Daniel F. (1997). Bayesian interim analysis of phase II cancer clinical trials. Statistics in Medicine 16, 1791-1802.
  32. Heitjan, Daniel F. (1997). Ignorability, sufficiency and ancillarity. Journal of the Royal Statistical Society, Series B 59, 375-381.
  33. Heitjan, Daniel F. and Sharma, Divakar (1997). Modeling repeated-series longitudinal data. Statistics in Medicine 16, 347-355.
  34. Heitjan, Daniel F. and Basu, Srabashi (1996). Distinguishing "missing at random" and "missing completely at random". The American Statistician 50, 207-213.
  35. Heitjan, Daniel F. (1995). Bayesian analysis of a protocol for sampling preserved tumor specimens. Journal of the American Statistical Association 90, 38-44.
  36. Heitjan, Daniel F. (1994). Ignorability in general incomplete-data models. Biometrika 81, 701-708.
  37. Heitjan, Daniel F. and Landis, J. Richard (1994). Assessing secular trends in blood pressure: A multiple-imputation approach. Journal of the American Statistical Association 89, 750-759.
  38. Heitjan, Daniel F. (1993). Ignorability and coarse data: some biomedical examples. Biometrics 49, 1099-1109.
  39. Heitjan, Daniel F., Manni, Andrea and Santen, Richard J. (1993). Statistical analysis of in vivo tumor growth experiments. Cancer Research 53, 6042-6050.
  40. Smith, Philip J. and Heitjan, Daniel F. (1993). Testing and adjusting for departures from nominal dispersion in generalized linear models. Applied Statistics 42, 31-41.
  41. Heitjan, Daniel F., Derr, Janice A. and Satyaswaroop, Pondichery G. (1992). The multi-site tumor transplantation model for human endometrial carcinoma: a statistical evaluation. Cell Proliferation 25, 193-203.
  42. Heitjan, Daniel F., Houts, Peter S. and Harvey, Harold A. (1992). A decision-theoretic evaluation of early stopping rules. Statistics in Medicine 11, 673-683.
  43. Heitjan, Daniel F. (1991). Generalized Norton-Simon models of tumor growth. Statistics in Medicine 10, 1075-1088.
  44. Heitjan, Daniel F. (1991). Nonlinear modeling of serial immunologic data: a case study. Journal of the American Statistical Association 86, 891-898.
  45. Heitjan, Daniel F. (1991). Regression with bivariate grouped data. Biometrics 47, 549-562.
  46. Heitjan, Daniel F. and Little, Roderick J. A. (1991). Multiple imputation for the Fatal Accident Reporting System. Applied Statistics 40, 13-29.
  47. Heitjan, Daniel F. and Rubin, Donald B. (1991). Ignorability and coarse data. Annals of Statistics 19, 2244-2253.
  48. Heitjan, Daniel F. and Rubin, Donald B. (1990). Inference from coarse data via multiple imputation with application to age heaping. Journal of the American Statistical Association 85, 304-314.
  49. Heitjan, Daniel F. (1989). Inference from grouped continuous data: a review (with discussion). Statistical Science 4, 164-183.

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