Mary Beth Leonard, MD, MSCE

Office LocationRoom 1564, 3535 Market
Office Phone215-590-0874

Faculty Information

CCEB AppointmentSenior Scholar, Epidemiology
Primary Faculty AppointmentProfessor of Pediatrics, Nephrology Division, University of Pennsylvania SOM/CHOP
DBE AppointmentProfessor of Epidemiology

Research Statement

Dr. Leonard is an Associate Professor of Pediatrics in the Division of Nephrology at the Childrenís Hospital of Philadelphia, and a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania. She has established a multidisciplinary research program in clinical bone disease in children and adults. Her research program is focused on (1) the accurate assessment and diagnosis of osteoporosis in children with chronic disease, (2) the detrimental effects of glucocorticoid therapy, muscle deficits and inflammation on bone development in varied pediatric disorders, (3) the assessment of the unique effects of kidney disease, dialysis and transplantation on skeletal structure in children and adults using novel micro-imaging techniques, (4) the effects of vitamin D deficiency on physical functioning and cardiovascular disease in adults with chronic kidney disease, and (5) the evaluation of biomechanical interventions as potential anabolic bone therapies in patients with chronic disease.

Dr. Leonardís research program is supported by multiple NIH investigator-initiated grants, including 3 R01s,and an NIDDK K24 mid-career award. Most recently, she was awarded a grant to conduct a randomized clinical trial of low magnitude mechanical stimuli as an anabolic bone therapy in children with Crohn disease. She also serves as the primary mentor for multiple junior faculty and fellows that are supported by Foundation grants and NIH K awards. Overall, her program has catalyzed interactions among nephrology, nutrition, gastroenterology, endocrinology, rheumatology, radiology, statistics and epidemiology.

Selected Publications

Leonard MB, Feldman HI, Shults J, Foster BJ, Zemel BS, Stallings VA. High dose chronic glucocorticoids and bone mineral content in children with nephrotic syndrome. N Engl J Med 351:868-875, 2004. PMID15329424

Burnham JM, Shults J, Semeao E, Zemel BS, Foster BJ, Stallings VA, Leonard MB. Whole body bone mineral content in pediatric Crohn disease: Independent effects of altered growth, maturation, and body composition. J Bone Min Res 19:1961-1968, 2004. PMID15537438

Petit MA, Beck TJ, Zemel BS, Shults J, Leonard MB. Proximal femur bone strength is appropriately adapted to lean mass in overweight children and adolescents. Bone 36:568-576, 2005. PMID15777684

Burnham JM, Shults J, Semeao E, Foster BJ, Zemel BS, Stallings VA, Leonard MB. Body-composition alterations consistent with cachexia in children and young adults with Crohn disease. Am J Clin Nutr 82: 413-420, 2005. PMID16087987

Burnham JM, Shults J, Weinstein R, Lewis JD, Leonard MB. Childhood onset arthritis is associated with an increased risk of fracture: a population-based study using the General Practice Research Database. Ann Rheum Dis 65:1074-1079, 2006. PMID16627541

Hopper TAJ, Wehrli FW, Saha PK, Andre JB, Wright AC, Sanchez CP, Leonard MB. Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular and cortical bone architecture in a rat model of severe renal osteodystrophy. J Comput Assist Tomogr 31:320-8, 2007. PMID17414773

Burnham JM, Shults J, Petit MA, Semeao E, Beck TJ, Zemel BS, Leonard MB. Alterations in proximal femur geometry in children treated with glucocorticoids for Crohn disease or nephrotic syndrome: impact of the underlying disease. J Bone Miner Res 22: 551-9, 2007. PMID17243860

Thayu M, Shults J, Burnham JM, Zemel BS, Baldassano RN, Leonard MB. Gender differences in body composition deficits at diagnosis in children and adolescents with Crohn's disease. Inflamm Bowel Dis 13: 1121-8, 2007. PMID17427245

Burnham JM, Shults J, Dubner S, Sembhi H, Zemel BS, Leonard MB. Bone density, structure, and strength in juvenile Idiopathic Arthritis: importance of disease severity and muscle deficits. Arthritis Rheum 58: 2518-27, 2008. PMID18668565

Sun W, Shults J, Leonard MB. A note on the use of unbiased estimating equations to estimate correlation in analysis of longitudinal trials. Biometrical Journal 51: 5-18, 2008. PMID19197953

Muntner P, Jones TM, Hyre AD, Melamed ML, Alper A, Raggi P, Leonard MB. Association of serum intact with lower estimated glomerular filtration rate. Clin J Am Soc Neph 4: 186-94, 2009. PMID19019998

Wetzsteon RJ, Shults J, Zemel BS, Gupta PU, Burnham JM, Herskovitz RM, Howard KM, Leonard MB. Divergent effects of glucocorticoids on cortical and trabecular compartment bone mineral density in childhood nephrotic syndrome. J Bone Miner Res 24:503-513, 2009. PMID19016583

Dubner SE, Shults J, Baldassano RN, Zemel BS, Thayu M, Burnham JM, Herskovitz RM, Howard KM, Leonard MB. Longitudinal assessment of bone density and structure in an incident cohort of children with Crohn's disease. Gastroenterology 136: 123-30, 2009. PMID19026647

Sethna CB, Salerno AE, McBride MG, Shults J, Paridon SM, Sharma N, Meyers KEM, Leonard MB. Cardiorespiratory Fitness in Pediatric Renal Transplant Recipients. Transplantation (in press) 2009.

Leonard MB, Elmi A, Mostoufi-Moab S, Shults J, Burnham JM, Thayu M, Kibe L, Wetzsteon RJ, Zemel BS. Effects of Sex, Race and Puberty on Cortical Bone and the Functional Muscle Bone Unit in Children, Adolescents and Young Adults. J Clin Endocrinol Metab (in press) 2010.

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