Jason Christie, MD, MSCE
| Office Location | 719, Blockley Hall |
| Office Phone | 215-573-3209 |
| jchristi@mail.med.upenn.edu | |
Faculty Information | |
| CCEB Appointment | Senior Scholar, Epidemiology |
| Primary Faculty Appointment | Associate Professor of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman SOM |
| DBE Appointment | Associate Professor of Epidemiology |
Research Statement
Jason D. Christie, M.D., M.S. is the Section Chief of Medical Critical Care. He is currently Associate Professor of Medicine in the Department of Pulmonary/Critical Care Medicine and Associate Professor of Epidemiology in the Department of Biostatistics and Epidemiology at the University of Pennsylvania. He is a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics, and the Director of Clinical Research in the Pulmonary Division. His career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury (ALI) in the transplant and non-transplant human populations.
Currently, Dr. Christie has extramural funding to support active research on somatic genetic variation, gene expression, and protein biomarkers in the etiology and pathogenesis of acute lung injury in the transplant, sepsis, and trauma populations. His research brings together clinicians, basic scientists, epidemiologists, and statisticians to build multidisciplinary studies of acute lung injury research.
Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). His research focuses on the role of oxidative stress, coagulation/fibrinolysis, inflammatory and innate immune pathways in primary graft dysfunction. This line of research is funded by three R01 grants from NHLBI, one focusing on genetic risks, and a second focusing on plasma protein biomarkers as risk factors for primary graft dysfunction. The third R01 is in close collaboration with Dr. David Wilkes, and focuses on the role of autoimmunity to type V collagen in primary graft dysfunction pathogenesis. In addition, he is a project leader in the Clinical Trials in Organ Transplantation consortium, funded through NIH. The goals of this project are to test the association between inflammatory gene mRNA expression in the donor and acute lung injury following the lung transplantation, as well as link early mRNA profiles with acute rejection occurring during the first year. Furthermore, Dr. Christie is the Associate Medical Director of the UNOS/ISHLT lung transplant registry, and primarily authors the registry report each year.
Dr. Christie is a project leader on a program project grant (Aron Fisher, PI) investigating genetic risks for ALI following trauma. He recently formed a multicenter collaboration, called the Trauma ALI SNP Consortium (TASC) to perform genome wide genetic association studies of ALI risk and outcomes. In addition, through the ARDSnet, he is currently conducting an ancillary study evaluating the long-term cognitive and neurological outcomes following ALI/ARDS.
Selected Publications
Critical Care:Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova E, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, Christiani DC, O'Keefe GE, Ware LB, May AK, Wurfel MM, Hakonarson H,and Christie JD: ANGPT2 Genetic Variant Is Associated with Trauma-Associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio. American Journal of Respiratory and Critical Care Medicine Page: In Press, Jan 2011
Shah CV, Lanken P, Localio AR, Gallop R, Bellamy S, Ma SF, Flores C, Kahn J, Finkel B, Fuchs B, Garcia JGN, Christie JD: An Alternative Method of Acute Lung Injury Classification for Use in Observational Studies. Chest 138: 1054-1061, Nov 2010.
Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD: Serum Lactate is Associated with Mortality in Severe Sepsis Independent of Organ Failure and Shock. Critical Care Medicine 37(5): 1670-7, May 2009.
Christie JD, Ma SF, Aplenc R, Li M, Lanken PN, Fuchs B, Albelda SM, Flores C, Garcia JGN: Variation in the MYLK Gene is Associated with Development of Acute Lung Injury Following Major Trauma. Critical Care Medicine 36(10): 2794-800, October 2008.
Shah CV, Localio AR, Lanken PN, Kahn JM, Bellamy S, Gallop R, Finkel B, Gracias V, Fuchs BD, Christie JD: Impact of Acute Lung Injury on Mortality in Critically Ill Trauma Patients Critical Care Medicine 36(8): 2309-15, August 2008.
Netzer G, Shah CV, Iwashyna TJ, Lanken PN, Finkel B, Fuchs B, Guo W, Christie JD: Red Cell Transfusion is a Risk Factor for Death After Acute Lung Injury. Chest 132(4): 1116-23, Oct 2007.
Christie JD*, Marzec J*, Reddy S, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Cho HY, Kleeberger SR. Functional Polymorphisms in the Transcription Factor NRF2 are Associated with Increased Risk of Acute Lung Injury. FASEB Journal 2007 Jul;21(9):2237-46. (* indicates equal contribution to the work)
Lung Transplantation:
Christie JD, Bellamy S, Ware LB, Lederer D, Hadjiliadis D, Lee J, Robinson N, Localio AR, Wille K, Lama V, Palmer S, Orens J, Weinacker A, Crespo M, Demissie E, Kimmel SE, Kawut SM: Construct Validity of the Definition of Primary Graft Dysfunction Following Lung Transplantation. Journal of Heart and Lung Transplantation 29(11): 1231-9, Nov 2010.
Thabut G, Christie JD, Kremers WK, Fournier M, Halpern SD: Survival differences following lung transplantation among United States transplant centers JAMA 7(304): 53-60, July 2010.
Christie JD, Shah CV, Kawut SM, Mangalmurti N, Lederer DJ, Sonett JR, Ahya VN, Palmer SM, Wille K, Lama V, Shah PD, Shah A, Weinacker A, Deutschman CS, Kohl BA, Demissie E, Bellamy S, Ware LB, for the Lung Transplant Outcomes Group : Plasma Levels of Receptor for Advanced Glycation End-Products (sRAGE), Blood Transfusion, and Risk Of Primary Graft Dysfunction. American Journal of Resp and Crit Care 180: 1010-1015, November 2009
Thabut G, Christie JD, Ravaud P, Castier Y, Dauriat G, Jebrak G, Fournier M, Lesèche G, Porcher R, Mal H: Survival after bilateral versus single lung transplantation for patients with idiopathic pulmonary fibrosis. Annals of Internal Medicine 151: 767-774, Dec 2009
Hoffman SA, Wang L, Shah CV, Ahya VN, Pochettino A, Olthoff K, Shaked A, Wille K, Lama V, Milstone A, Ware LB, Orens J, Weinacker A, Demissie E, Bellamy S, Kawut SM, Hancock WW, Christie JD for the Lung Transplant Outcomes Group: Plasma Cytokines and Chemokines in Primary Graft Dysfunction Post-Lung Transplantation. American Journal of Transplantation 9(2): 389-396, Feb 2009.
Iwata T, Philipovskiy A, Fisher AJ, Presson RG, Chiyo M, Lee J, Mickler E, Smith GN, Petrache I, Brand DB, Burlingham W, Gopalakrishnan B, Greenspan DS, David S. Wilkes*, Christie JD* (Co-senior authors due to equal contributions): Anti-type V Collagen Humoral Immunity in Lung Transplant Primary Graft Dysfunction. Journal of Immunology 181: 5738-5747, October 2008.
Covarrubias MB, Ware LB, Kawut S, DeAndrade J, Milstone A, Weinacker A, Lama V, Christie JD: Plasma Intercellular Adhesion Molecule-1 (ICAM) and Von Willebrand Factor (VWF) in Primary Graft Dysfunction Following Lung Transplantation. American Journal of Transplantation 7(11): 2573-8, Nov 2007
Christie JD, Robinson N, Ware L, Plotnick M, DeAndrade J, Lama V, Milstone A, Orens J, Weinacker A, DeMissie E, Bellamy S, Kawut S, for the Lung Transplant Outcomes Group. Association Of Protein C And Type-1 Plasminogen Activator Inhibitor With Primary Graft Dysfunction Am J Respir Crit Care Med 2007 Jan 1;175(1):69-74.
Christie JD, Kotloff RM , Ahya VN, Tino G, Pocchetino A, Gaughan C, DeMissie E, Kimmel SE. The Effect of Primary Graft Dysfunction on Survival Following Lung Transplantation. Am J Respir Crit Care Med 2005 171(11):1312-1316.
