Sean Hennessy, PharmD, PhD
| Office Location | 803, Blockley Hall |
| Office Phone | 215-898-9112 |
| hennessy@upenn.edu | |
| Personal Website | http://www.cceb.upenn.edu/hennessy/cv.html |
Faculty Information | |
| CCEB Appointment | Senior Scholar, Epidemiology |
| Primary Faculty Appointment | Associate Professor of Epidemiology, University of Pennsylvania SOM |
Additional Positions
Associate Professor of Pharmacology, Department of Pharmacology
Director of Ambulatory Drug Use and Effects, University of Pennsylvania Medical Center
Senior Fellow, The Leonard Davis Institute of Health Economics
Fellow, Institute on Aging
Regional Editor for the Americas, Pharmacoepidemiology and Drug Safety
Member, Subcommittee on Vaccine Safety of the National Vaccine Advisory Committee, US Department of Health and Human Services
Research Statement
Dr. Hennessy’s primary field of interest is pharmacoepidemiology, which is the study of the use and effects of medications in populations. Dr. Hennessy’s research has been funded by the Agency for Healthcare Research and Quality (AHRQ), the National Institutes of Health (NIH), pharmaceutical companies, and private foundations. He is currently leading NIH-funded studies on drug-induced sudden death and ventricular arrhythmia, and on the clinical importance of drug-drug interactions. He is the principal investigator of Penn’s AHRQ-funded “Developing Evidence to Inform Decisions About Effectiveness” (DEcIDE) center, and a co-principal investigator of Penn’s AHRQ-funded Center for Education and Research on Therapeutics (CERT).
In addition to his research, Dr. Hennessy teaches clinical epidemiology to medical and graduate students, and is active in promoting evidence based practice at Penn, directing its Ambulatory Drug Use and Effects Program, and serving on its Pharmacy and Therapeutics Committee. Dr. Hennessy’s clinical program has received two Quality and Safety Awards from the University of Pennsylvania Health System. Dr. Hennessy received the 2005 Young Alumnus Award from the University of the Sciences in Philadelphia and the 2008 Leon I. Goldberg Young Investigator Award from the American Society for Clinical Pharmacology and Therapeutics.
Courses Taught
EPID 666 - Pharmacoepidemiology Research
Selected Publications
Hennessy S, Leonard CE, Palumbo CM, Shi X, Ten Have TR. Instantaneous Preference was a stronger Instrumental Variable than three- and six-month prescribing preference for NSAIDs. Journal of Clinical Epidemiology 2008;61:561-571.
Haynes K, Heitjan D, Kanetsky P, Hennessy S. Declining public health burden of digoxin toxicity from 1991 to 2004. Clinical Pharmacology and Therapeutics 2008; 84:90-94.
Meropol SB, MD, Chan KA, Chen Z, Finkelstein JA, Hennessy S, Lautenbach E, Platt R, Schech SD, Shatin D, Metlay JP. Adverse events associated with prolonged antibiotic use. Pharmacoepdemiology and Drug Safety 2008;17:523-532.
Haynes K, Hennessy S, Morales KH, Gibson GA, Barnhart C, Jaipaul CK, Linkin DR. Inter-rater reliability of a classification system for hospital adverse drug event reports. Clinical Pharmacology and Therapeutics 2008; 83:485-488.
Hennessy S, Leonard CE, Palumbo CM, Newcomb C, Bilker WB. Quality of Medicaid and Medicare data obtained through CMS. Medical Care 2007;45:1216-1220.
Hennessy S, Bilker WB, Leonard CL, Chittams J, Palumbo CM, Karlawish JH, Yang Y-X, Lautenbach E, Baine WB, Metlay JP. Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures. Journal of Clinical Epidemiology 2007;60:911e-918e.
Mansson R, Sun W, Joffe MM, Hennessy S. On the estimation and use of propensity scores in case-control and case cohort studies. American Journal of Epidemiology 2007;165:1-8.
Hennessy S, Leonard C, Yang W, Kimmel S, Townsend R, Wasserstein A, Ten Have T, Bilker W. Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial. Pharmacotherapy 2006;26:1342-1347.
Apter A, Kinman J, Bilker W, Herlim M, Margolis D, Lautenbach E, Hennessy S, Strom B. Is there cross-reactivity between penicillins and cephalosporins? American Journal of Medicine 2006;119:354e11-19.
Halpern S, Barton T, Gross R, Hennessy S, Berlin J, Strom B. Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reported? Pharmacoepidemiology and Drug Safety 2005;14:155-161.
