Kathleen J. Propert, ScD

Office Location614, Blockley Hall
Office Phone215-746-8603
Emailpropert@mail.med.upenn.edu

Faculty Information

CCEB AppointmentSenior Scholar, Biostatistics
Primary Faculty AppointmentProfessor of Biostatistics at HUP, University of Pennsylvania Perelman SOM

Research Statement

Dr. Propert's main area of research and expertise is the design and conduct of animal experiments and multi-center clinical trials. She has served as co-director of multiple Data Coordinating Centers (DCCs), especially in urology. Her current focus is on methods and collaborations in T1 Translational Research as Director of the Biostatistics Core for the Institute for Translational Medicine and Therapeutics (ITMAT), the primary home of the CTSA at UPenn. Primary clinical applications include lipid metabolism, dermatology, and head injury.

Dr. Propert's methodological research is related to optimal study design, especially for animal experiments and early stage clinical trials. Work in progress includes optimal design for animal toxicity studies of mixtures of drugs, adaptive design for clinical trials in rare diseases, and biomarker development in a high-throughput in-vivo assay. Related research focuses on the interaction of research ethics and statistical methods.

Courses Taught

BSTA 658: Design of Biomedical Studies II
BSTA 786: Advanced Topics In Clinical Trials

Selected Publications

Hsu C, Propert K, Xie D, Hamm L, He J, Miller E, Ojo A, Shlipak M, Teal V, Townsend R, Weir M, Wilson J, Feldman H, for the CRIC Investigators: Measured GFR Does Not Outperform Estimated GFR in Predicting CKD-related Complications. Journal of the American Society of Nephrology: JASN 22(10): 1931-37, Oct 2011.

Jain V, Abdulmalik O, Propert KJ, Wehrli FW: Investigating the Magnetic Susceptibility Properties of Fresh Human Blood for Noninvasive Oxygen Saturation Quantification. Magnetic Resonance in Medicine Dec 2011 Notes: Epub ahead of print.

Zhang H, Qiao H, Frank RS, Huang B, Propert KJ, Margulies S, Ferrari VA, Epstein JA, Zhou R
: Spin Labeling-MRI Detects Increased Myocardial Blood Flow Post Endothelial Cell Transplantation in the Infarcted Heart. Circulation, Cardiovascular Imaging 5(2): 210-7, Mar 2012.

Skarke C, Alamuddin N, Lawson JA, Cen L, Propert KJ, Fitzgerald GA: Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649. Clinical Pharmacology & Therapeutics 91(6): 986-93, June 2012.

Lunardon L, Tsai KJ, Propert KJ, Fett N, Stanley JR, Werth VP, Tsai DE, Payne AS: Adjuvant Rituximab Therapy of Pemphigus: a Single Center Experience with 31 Patients. Archives of Dermatology 2012






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