Mary E. Putt, PhD, ScD
|Office Location||621, Blockley Hall|
|CCEB Appointment||Senior Scholar, Biostatistics|
|Primary Faculty Appointment||Associate Professor of Biostatistics at HUP, University of Pennsylvania Perelman SOM|
Director, Educational Programs in Biostatistics
Dr. Putt's research interests are in crossover trials and the analysis of gene expression data. In a crossover trial, subjects receive more than one treatment sequentially. A crossover design can be an effective research tool for a chronic disease because it is highly efficient. However, the estimate of the treatment effect may be aliased with nuisance parameters, and particularly carryover. Carryover can be thought of as the effect of a treatment that lingers into the period following its administration. Dr. Putt's research examines both theoreticall aspects of analyzing crossover studies, as well as some practical issues involved in making the decision to use a crossover trial in a clinical study.
Dr. Putt's main collaborations are currently in the areas of cancer research, mental retardation and developmental disabilities, and heart disease. She also is involved in collaborative research examining effect of distrust and segregation on disparities in health outcomes among different racial/ethnic groups.
Armstrong K, Micco E, Carney E, Stopfer J, Weber B, Putt, M. Racial Differences in the Use of BRCA1/2 Testing Among Women with a Family History of Breast or Ovarian Cancer. Journal of the American Medical Association. 2005. In Press.
Putt, M. Testing for carryover in collections of croosver studies. Statistics in Medicine. 2005. In press.
Putt, M and Chinchilli, V. Nonparametric analysis of crossover trials. Statistical Science 2004; 19(40): 712-719.
Ravina, B. Putt, M. Siderowf, A. Farrar, J. Gillespie, M. Crawley, A. Fernandez, H. Treischmann, M. Reichweiln, S. Simuni. T. Donepezil for dementia in Parkinson's disease. A randomized double-blind placebo controlled crossover study. Journal of Neurology, Neurosurgery and Psychiatry. 2005. In Press.
Putt ME, Ravina B. Placebo-Controlled Crossover versus Parallel Group Study Designs for the Study of Dementia in Parkinson’s Disease. Controlled Clinical Trials. 2002, 23:111-126.
Putt M, Chinchilli VM. Estimating the asymptotic variance of generalized L-statistics. Communications in Statistics 2002, 31:733-752.
Abrahams JM, Torchia M, Putt M, Kaiser LR, Judy KD Risk factors for survival following brain metastases from non-small lung cancer: A follow-up study of 70 patients. Journal of Neurosurgery. 2001, 95:595-600
Armstrong K, Schwartz JS, FitzGerald G, Putt M, Ubel PA. Effect of Framing as Gain vs. Loss on Understanding and Hypothetical Treatment Choices: Survival and Mortality Curves. Medical Decision Making 2001, 21:1-10.
Putt M, Chinchilli VM. A robust analysis of crossover designs using multisample generalized L-statistics. Journal of the American Statistical Association. 2000, 95(452):1256-1262
Putt M, Chinchilli VM. A mixed effects model for the analysis of repeated measures cross-over studies. Statistics in Medicine 1999; 18:3037-3058.