Ebbing Lautenbach, MD, MPH, MSCE
| Office Location | 825, Blockley Hall |
| Office Phone | (215) 898-6977 |
| ebbing@mail.med.upenn.edu | |
| Personal Website | http://www.uphs.upenn.edu/idd/Lautenbach.html |
Faculty Information | |
| CCEB Appointment | Senior Scholar, Epidemiology |
| Primary Faculty Appointment | Associate Professor of Medicine, Infectious Diseases Division, University of Pennsylvania SOM |
| DBE Appointment | Associate Professor of Epidemiology |
Additional Positions
Fellow, Institute on Aging, University of Pennsylvania School of Medicine
Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine
Senior Fellow, Center for Public Health Initiatives, University of Pennsylvania School of Medicine
Associate Hospital Epidemiologist, Hospital of the University of Pennsylvania
Associate Director, Clinical Epidemiology Unit, Educational Programs
Research Statement
Dr. Lautenbach's research focuses on antibiotic use, antimicrobial resistance, outbreak investigation, and epidemiologic methods in the study of infectious diseases. This research focuses on various healthcare settings including acute care hospitals and long term care facilities. With regard to gram-positive infections, his specific focus has been on patterns of use of vancomycin, vancomycin intolerance, and the relationship of the use of this agent to the epidemiology of vancomycin-resistant enterococcal (VRE) infections. Furthermore, he is investigating the emergence of extended-spectrum beta-lactamase (ESBL) resistance among gram-negative organisms, particularly how the dissemination of this resistance mechanism responds to manipulations of hospital antimicrobial formularies. Finally, Dr. Lautenbach is studying patterns of use of the fluoroquinolone antibiotics, as well as how such use patterns affect current trends in resistance to these agents.
Courses Taught
Course Director, Critical Appraisal of the Medical Literature
Course Director, Epidemiological Research Methods in Infectious Diseases
Selected Publications
Lautenbach E, Patel JB, Bilker WB, Edelstein PH, Fishman NO.: Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes. Clinical Infectious Diseases 2001;32:1162-71
Lautenbach E, Fishman NO, Bilker WB, Castiglioni A, Metlay JP, Edelstein PH, Strom BL.: Risk factors for fluoroquinolone resistance in nosocomial Escherichia coli and Klebsiella pneumoniae infections. Archives of Internal Medicine 2002;162:2469-77
Lautenbach E, Strom BL, Nachamkin I, Bilker WB, Marr AM, Larosa LA, Fishman NO.: Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, (1989-2000): Differences in the emergence and epidemiology of resistance across organisms. Clinical Infectious Diseases 2004;38:655-62
Mikanatha N, Welliver DP, Rohn DD, Julian KG, Lautenbach E.: Use of the web by state and territorial health departments to promote reporting of infectious disease. JAMA 2004;291:1069-70
Maslow JN, Lautenbach E, Glaze T, Bilker WB, Johnson JR.: Colonization with extraintestinal pathogenic Escherichia coli among nursing home residents and its relationship to fluoroquinolone resistance. Antimicrobial Agents and Chemotherapy 2004;48:3618-20
Maslow JN, Lee B, Lautenbach E. Fluoroquinolone-resistant Escherichia coli carriage in long term care facility. Emerging Infectious Diseases 2005;11:889-94
Hyle EP, Lipworth AD, Zaoutis TE, Nachamkin I, Bilker WB, Lautenbach E. Impact of inadequate initial antibiotic therapy on mortality in infections due to extended spectrum ß-lactamase-producing Enterobacteriaceae: Variability by site of infection. Archives of Internal Medicine 2005;165:1375-80
Lautenbach E, Fishman NO, Metlay JP, Mao X, Bilker WB, Tolomeo P, Nachamkin I. Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: Results from a large hospital-based surveillance initiative. Journal of Infectious Diseases 2006;194:79-85
Lautenbach E, Metlay JP, Bilker WB, Edelstein PH, Fishman NO.: Association between fluoroquinolone resistance and mortality in Escherichia coli and Klebsiella pneumoniae infections: The role of inadequate empirical antimicrobial therapy. Clinical Infectious Diseases 2005;41:923-9
Gasink LB, Blumberg EA, Localio AR, Desai SS, Israni AK, Lautenbach E. Hepatitis C virus seropositivity and survival in heart transplant recipients. JAMA 2006;296:1843-50
Lautenbach E. Expanding the universe of methicillin-resistant Staphylococcus aureus prevention. Ann Intern Med 2008;148:474-6
