James Lewis, MD, MSCE
| Office Location | 720, Blockley Hall |
| Office Phone | (215) 573-5137 |
| lewisjd@mail.med.upenn.edu | |
Faculty Information | |
| CCEB Appointment | Senior Scholar, Epidemiology |
| Primary Faculty Appointment | Associate Professor of Medicine, Gastroenterology Division, University of Pennsylvania SOM |
| DBE Appointment | Associate Professor of Epidemiology |
Additional Positions
Senior Fellow, Leonard Davis Institute
Research Statement
Dr. Lewis has focused his research on outcomes associated with the use of medications and endoscopy, particularly in the context of inflammatory bowel disease, gastrointestinal malignancies and peptic ulcer disease. In the area of inflammatory bowel disease, Dr. Lewis has studied the risk of lymphoma with azathioprine therapy, the association between azathioprine dose, metabolite levels and clinical outcomes, risk factors for relapse of IBD, the role of PPAR-gamma ligands as a novel therapy for ulcerative colitis, and methods to improve the conduct of clinical trials.
Recent work on gastrointestinal malignancies includes a meta-analysis of screening colonoscopy studies describing the association between distal colonic findings and proximal colonic neoplasia and several epidemiological studies focusing on risk factors for colorectal cancer. Dr. Lewis is currently studying the association of PPAR-gamma ligand therapy and the risk for colonic neoplasia.
In the area of peptic ulcer disease, Dr. Lewis recently completed a population-based case-control study to examine medications as risk factors for peptic ulcer disease and its complications. This study focused primarily on the association between upper gastrointestinal bleeding and use of over-the-counter NSAIDs.
Dr. Lewis has also directed epidemiology methods research. These studies have focused on improving methods for research with electronic medical records and measurement of exposures in epidemiology studies.
Courses Taught
EP 510 – Introductory Epidemiology
Selected Publications
Kandiel A, Fraser AJ, Korelitz BI, Brensinger C, Lewis JD. Increased Risk of Lymphoma among Inflammatory Bowel Disease Patients Treated with Azathioprine and 6-Mercaptopurine. Gut. 2005; 54(8):1121-5.
Lewis JD, Aberra FN, Lichtenstein GR, Bilker WB, Brensinger C, Strom BL. Seasonal variation in flares of inflammatory bowel disease. Gastroenterology 2004;126:665-73.
Su C, Lichtenstein GR, Krok K, Brensinger C, Lewis JD. A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn’s disease. Gastroenterology. 2004;126:1257-69.
Gupta G, Gelfand JM, Lewis JD. Increased risk of demyelinating diseases in patients with inflammatory bowel disease. Gastroenterology. 2005;129:819-26.
Yang Y, Hennessy S, Lewis JD. Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients. Gastroenterology. 2004;127:1044-50.
Lewis JD, Kimmel SE, Localio AR, Metz DC, Farrar JT, Nessel L, Brensinger C, McGibne K, Strom BL. Risk of serious upper gastrointestinal toxicity with over-the-counter non-aspirin non-steroidal anti-inflammatory drugs. Gastroenterology. 2005;129(6):1865-74.
Lewis JD, Bilker WB, Weinstein R, Strom BL. The relationship between time since registration and measured incidence rates in the General Practice Research Database. Pharmacoepidemiology and Drug Safety. 2005;14(7):443-51. Published online 16 May 2005.
Lewis JD, Strom BL, Kimmel SE, Farrar J, Metz DC, Brensinger C, Nessel C, Localio AR. Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposure. Pharmacoepidemiology and Drug Safety. 2006; 15(1):39-45.
