David Margolis, MD, PhD
| Office Location | 815, Blockley Hall |
| Office Phone | 215-898-4938 |
| margo@mail.med.upenn.edu | |
Faculty Information | |
| CCEB Appointment | Senior Scholar, Epidemiology |
| Primary Faculty Appointment | Professor of Dermatology, University of Pennsylvania SOM |
| DBE Appointment | Professor of Epidemiology |
Research Statement
Dr. Margolis's research work is focused on the epidemiology and treatment of chronic wounds. He currently is the Principal Investigator of several NIH, industry, and foundation grants, such as developing a prediction model for treating venous leg ulcers, creating prediction models for determining who will develop venous leg ulcers or pressure ulcers, and separate gene therapy phase I studies treating venous leg ulcers and diabetic foot ulcers.
Dr. Margolis's clinical focus is on the treatment of chronic wounds of the skin. He was a board member of the National Pressure Advisory Panel, and of the Wound Healing Society. He is currently a board member of the International Dermato-epidemiology Association, Dermato-epidemiology Association Americas chapter and the Wound Healing Consortium. He is an Associate Editor of Pharmacoepidemiology and Drug Safety and is on the editorial boards of Archives of Dermatology, Journal of the American Academy of Dermatology, Wounds, Cocharane Wound Group, and Wound Repair and Regernation. He was a member of the Agency for Health Care Policy and Research Panel for the Treatment of Pressure Ulcers. In addition, he was a member of a NIH/NIAMS working group on dermato-epidemiology and NIH Interagency Coordinating Committee on Venous Stasis Ulcers, and was a member of the FDA-Biologics Chronic Wound Advisory Board. He serves on several Data Safety Monitoring boards. He has written more than 100 peer reviewed research or review publications and 10 book chapters.
Selected Publications
Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Pecoraro R, Rodeheaver GT, and Robson MC. Definitions and Guidelines for Assessment of Wounds and Evaluation of Healing. Arch Dermatol 130:489-493, 1994.
Margolis DJ, Attie M, and Leyden JJ. The effects of isotretinoin on bone mineralization during routine therapy with isotretinoin for acne vulgaris. Arch Dermatol: 132:769-774, 1996.
Margolis DJ, Berlin J, Strom BL. Interobserver agreement, sensitivity, and specificity of a "healed" chronic wound. Wound Repair Regen: 4: 335-338, 1996.
Falanga V, Margolis DJ, Alvaraez O, Auletta M, Maggiacomo F, Altman M., Jensen J, and the Graftskin Investigators Group. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Arch Dermatol: 134:293-300, 1998.
Kantor J, Margolis DJ. From clinical trials to clinical practice: The efficacy and prognostic value of simple wound measurements. Arch Dermatol: 134:1571-1574, 1998.
Margolis DJ, Halpern AC, Rebbbeck T, Schuchter L, Barnhill RL, Fine J, Berwick M. Validation of a melanoma prognostic model. Arch Dermatol: 134:1597-1601, 1998.
Margolis DJ, Berlin JA, Strom BL. A Comparison of Sensitivity Analyses of the Effect of Wound Duration on Wound Healing. J Clin Epidemiol: 52(2):123-128, 1999.
Margolis DJ, Kantor J, Berlin JA. Healing of diabetic foot ulcers receiving standard treatment: a meta-analysis. Diabetes Care 22:692-696, 1999.
Margolis DJ, Berlin JA, Strom BL. Risk Factors Associated with the Failure of a Venous Leg Ulcer to Heal. Arch Dermatol: 135: 920-926, 1999.
Miller JJ, Roling D, Margolis D, Gusso C. Failure to demonstrate therapeutic tachyphylaxis to topically applied steroids in patients with psoriasis. J Am Acad Dermatol 41: 546-569, 1999.
Kantor J, Margolis DJ. The accuracy of using a wound care specialty clinic database to study diabetic neuropathic foot ulcers. Wound Rep Regen 8:169-173, 2000.
Margolis DJ, Kantor J, Santanna J, Strom BL, Berlin JA. Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 24: 483-488, 2001.
Kantor J, Margolis DJ. Treatment options for diabetic neuropathic foot ulcers: a cost-effective analysis. Dermatol Surg 27:347-351, 2001.
Margolis D, Bilker W, Hennessy S, Vittorio C, Santanna J, Strom BL. The risk of malignancy associated with psoriasis. Arch Dermatol 137:778-783, 2001.
Hennessy S, Berlin JA, Kinman JL, Margolis DJ, Marcus SM, Strom BL. Risk of Venous Thromboembolism from Oral Contraceptives Containing Gestodene and Desogestrel versus Levonorgestrel: A Meta-Analysis and Formal Sensitivity Analysis. Contraception 64:125-133, 2001.
Margolis DJ, Knauss J, Bilker W. Does Hormone Replacement Therapy Prevent Pressure Ulcers or Venous Leg Ulcers? The Lancet 359: 675-677, 2002.
Margolis DJ, Bilker W, Santanna J, Baumgarten M. Venous Leg Ulcer: The incidence and prevalence in the elderly. J Am Acad Dermatol 46: 381-386, 2002.
Margolis DJ, Bilker W, Knauss J, Baumgarten M, Strom BL. The incidence and prevalence of pressure ulcers among elderly patients in general medical practice. Ann Epidemiol 12: 321-325, 2002.
Margolis DJ, Bilker W, Boston R, Localio R, Berlin JA. Statistical Characteristics of Area Under the Receiver Operating Characteristic Curve for a Simple Prognostic Model Using Traditional and Bootstrapped Approaches. J Clin Epi 55: 518-524, 2002.
Margolis DJ, Taylor LA, Hoffstad O, Berlin JA. Diabetic neuropathic foot ulcer: The association of wound size, wound duration, and wound grade. Diabetes Care 25: 1835-9, 2002.
Hennessy S, Bilker WB, Knauss JS, Margolis DJ, Kimmel SE, Reynolds RF, Glasser DB, Morrison MF, Strom BL. Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ 325: 1070-1075, 2002.
Kantor J, Bilker WB, Glasser DB, Margolis DJ. Prevalence of erectile dysfunction and active depression: An analytical cross-sectional study of general medical patients. Am J Epidemiol,156: 1035-1042, 2002.
Gelfand JM, Hoffstad O, Margolis DJ. Surrogate endpoints for the treatment of venous leg ulcers. J Invest Dermatol. 119: 1420-1425, 2002.
Gruss CJ, Satyamoorthy K, Berking C, Lininger J, Nesbit M, Schaider H, Liu Z-J, Oka M, Hsu M, Shirakawa T, Li G, Bogenrieder T, Carmeliet P, El-Deiry WS, Eck SL, Rao JS, Baker AH, Bennett J, Crombleholme TM, Karmacharya J, Margolis DJ, Wilson JM, Werner S, Detmar M, Skobe M, Robbins PD, Johnson C, Buck C, Carbone D, Herlyn M: Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest. Dermatol. 120: 683-692, 2003.
Levy RM, Huang EY, Roling D, Leyden JJ, MD, Margolis DJ. Effects of antibiotics on the oro-pharyngeal flora in patients with acne. Arch Dermatol 139: 467-471, 2003.
Margolis, DJ, Knaus J, Bilker W, Baumgarten M. Medical conditions as risk factors for pressure ulcers in an outpatient setting. Age and Ageing, 32: 259-264, 2003.
Baumgarten M, Margolis D, Berlin JA, Strom BL, Garino J, Kagan SH, Kavesh W, Carson JL. Risk factors for pressure ulcers among elderly hip fracture patients. Wound Repair and Regeneration, 11: 96-103, 2003.
Margolis DJ, Gelfand JM, Hoffstad O, Berlin JA. Surrogate endpoints for the treatment of diabetic neuropathic foot ulcers. Diabetes Care, 26: 1696-1700, 2003.
