Harold I. Feldman, MD, MSCE

Office Location824, Blockley Hall
Office Phone215-898-0901

Faculty Information

CCEB AppointmentSenior Scholar, Epidemiology
Primary Faculty AppointmentGeorge S. Pepper Professor of Public Health and Preventive Medicine, University of Pennsylvania Perelman SOM
DBE AppointmentProfessor of Epidemiology and Medicine

Additional Positions

Chair, Department of Biostatistics and Epidemiology

Director, Center for Clinical Epidemiology and Biostatistics

Professor of Medicine in Pediatrics, Children's Hospital of Philadelphia

Senior Fellow, Leonard Davis Institute

Director Emeritus, Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania

Faculty Co-Director, Clinical Research Computing Unit, CCEB

Fellow, American College of Epidemiology

Fellow, American Society of Nephrology

Research Statement

Dr. Feldman's major research interests address the epidemiology of kidney diseases with a particular focus on the management of kidney disease from the stage of chronic kidney dysfunction to end-stage renal disease. He leads Penn-based researchers and several national research groups addressing various manifestations and treatment of kidney disease. These research programs address the causes of failure of vascular accesses used for hemodialysis, anemia and metabolic disorders of kidney disease, the determinants of long-term survival of kidney allografts, the epidemiology of drug-related kidney disease, the relationship of ethnicity and kidney disease, the inter-relationship between chronic kidney disease and cardiovascular disease, and pediatric kidney diseases. Dr. Feldman is the national study chair of the NIH/NIDDK's Hemodialysis Fistula Maturation Cohort Study and its Chronic Renal Insufficiency Cohort Study (CRIC) whose scientific and data coordinating he leads as Principal Investigator at Penn.

Selected Publications

Mange KC, Feldman HI, Joffe MM, Fa K, Bloom RD: Blood pressure and the survival of renal allografts from living donors. J Am Soc Nephrol, 15(1): 187-193, 2004.

Feldman HI, Joffe M, Robinson B, Knauss J, Cizman B, Franklin-Becker E, Faich G: Administration of parenteral iron and mortality among hemodialysis patients. J of American Society of Nephrology, 15:1623-1632, 2004.

Lowe RA, Localio AR, Schwarz DF, Williams S, Tuton LW, Maroney S, Nicklin D, Goldfarb N, Vojta DD, Feldman HI: Association between primary care practice characteristics and emergency department use in a Medicaid managed care organization. Medical Care, 43(8):792-800, 2005.

Weng FL, Israni AK, Joffe MM, Hoy T, Gaughan CA, Newman M, Abrams JD, Kamoun M, Rosas SE, Mange KC, Strom BL, Brayman KL, Feldman HI: Race and electronically-measured adherence to immunosuppressive medications after deceased donor renal transplantation. Journal of the American Society of Nephrology, 16(6):1839-1848, 2005.

Robinson BM, Joffe MM, Berns JS, Pisoni RL, Port FK, Feldman HI: Anemia and mortality in hemodialysis patients: Accounting for morbidity and treatment variables updated over time. Kidney International, 68:1-8, 2005.

Robinson BM, Joffe MM, Pisoni RL, Port FK, Feldman HI: Revisiting survival differences by race and ethnicity among hemodialysis patients: The Dialysis Outcomes and Practice Patterns Study. Journal of the American Society of Nephrology, 17:2910-2918, 2006.

Brunelli SM, Lewis JD, Gupta M, Latif SM, Weiner MG, Feldman HI: Risk of kidney injury following use of oral phosphosoda bowel preparations. Journal of the American Society of Nephrology, 18:3199-3205, 2007.

Yang W, Israni RK, Brunelli SM, Joffe M, Fishbane S, Feldman HI: Hemoglobin variability and mortality in ESRD. Journal of the American Society of Nephrology, 18:3164-3170, 2007.

Dember LM, Beck GJ, Allon M, Delmez JA, Dixon BS, Greenberg A, Himmelfarb J, Vazquez MA, Gassman JJ, Greene T, Radeva MK, Braden GL, Ikizler TA, Rocco MV, Davidson IJ, Kaufman JS, Meyers CM, Kusek JW, Feldman HI for the Dialysis Access Consortium Study Group: Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis. Journal of the American Medical Association, 299(18):2164-2171, 2008.

Margolis DJ, Hofstad O, Feldman HI: Association between renal failure and foot ulcer or lower-extremity amputation in patients with diabetes. Diabetes Care, 31(7):1331-1336, 2008.

Brunelli SM, Lynch KE, Thadhani RI, Anders ED, Joffe MM, Yang W, Feldman HI: Association of hemoglobin variability and mortality among contemporary incident hemodialysis patients. Clinical Journal of the American Society of Nephrology, 3:1733-1740, 2008.

Brunelli SM, Thadhani RI, Lynch KE, Ankers ED, Joffe MM, Boston R, Chang Y, Feldman HI: Association between long-term blood pressure variability and mortality among incident hemodialysis patients. American Journal of Kidney Diseases, 5:716-726, 2008.

Kamoun M, Holmes JH, Israni AK, Kearns JD, Teal V, Yang WP, Rosas SE, Joffe MM, Li H, Feldman HI: HLA-A amino acid polymorphism and delayed kidney allograft function. Proceedings of the National Academy of Sciences, 105(48):18883-18888, 2008.

den Hartog JR, Reese PP, Cizman B, Feldman HI: The costs and benefits of automatic glomerular filtration rate reporting. Clinical Journal of the American Society of Nephrology 4:419-427, 2009.

Dixon BS, Beck GJ, Vazquez MA, Greenberg A, Delmez JA, Allon M, Dember LM, Himmelfarb J, Gassman JJ, Greene T, Radeva MK, Davidson IJ, Ikizler TA, Braden GL, Fenves AZ, Kaufman JS, Cotton, Jr., JR, Martin KJ, McNeil JW, Rahman A, Lawson JH, Whiting, JF, Hu B, Meyers CM, Kusek JW, Feldman HI for the Dialysis Access Consortium (DAC) Study Group: Effect of dipyridamole plus aspirin on hemodialysis graft patency. New England Journal of Medicine, 360:2191-2201, 2009.

Levey AS, Stevens LA, Schmid CH, Zhang Y, Castro III AF, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J for the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI): A new equation to estimate glomerular filtration rate. Annals of Internal Medicine, 150(9):604-613, 2009.

Reese PP, Shea JA, Bloom RD, Berns JS, Gross R, Joffe M, Huverserian A, Feldman HI: Predictors of having a potential live donor: a prospective cohort study of kidney transplant candidates. American Journal of Transplantation, 9(12):2792-2799, 2009. (PMC2864790)

Lash JP, Go AS, Appel LJ, He J, Ojo A, Rahman M, Townsend RR, Xie D, Cifelli D, Cohan J, Fink JC, Fischer MJ, Gadegbeku C, Hamm LL, Kusek JW, Landis JR, Narva A, Robinson N, Teal V, Feldman HI: The Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline characteristics and associations with kidney function. Clinical Journal of the American Society of Nephrology, 4:1302-1311, 2009. (PMC2723966)

Reese PP, Halpern SD, Asch D, Bloom R, Nathan H, Hasz R, Roth J, Reitsma W, Krefski L, Goerlitz F, DeLauro G, Blumberg E, Weng FL, Caplan A, Thomasson A, Shults J, Feldman HI: Longer-term outcomes after kidney transplantation from seronegative deceased donors at increased risk for blood-borne viral infection. Transplantation 91(11):1211-1217, 2011.

Hsu C, Propert K, Xie D, Hamm L, He J, Miller E, Ojo A, Shlipak M, Teal V, Townsend R, Weir M, Wilson J, Feldman H and for the CRIC Investigators: Measured GFR does not outperform estimated GFR in predicting CKD-related complications. Journal of the American Society of Nephrology, 22:1931-1937, 2011.

Budoff MJ, Rader DJ, Reilly MP, Mohler ER, Lash J, Yang W, Rosen L, Glenn M, Teal V, Feldman HI on behalf of the CRIC Investigators: Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. American Journal of Kidney Diseases, 58(4):519-526, 2011.

Rosas SE, Feldman HI: Synthetic vascular hemodialysis access vs native arteriovenous fistula: A cost-utility analysis. Annals of Surgery 255(1):181-186, 2012.

Joffe MM, Yang W, Feldman HI: G-estimation and artificial censoring: problems, challenges, and applications. Biometrics 68:275-286, 2012.

Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St. John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-o M, Kusek JW, Keane MG, Wolf M: FGF23 induces left ventricular hypertrophy. J Clin Invest, 11(121):4393-4408, 2011. (PMC3204831)

Isakova T, Xie H, Yang W, Anderson AH, Scialla J, Wahl P, Gutierrez OM, Steigerwalt S, He J, Schwartz S, Lo J, Ojo A, Sondheimer J, Hsu C-Y, Lash J, Leonard M, Kusek JW, Feldman HI, Wolf M for the Chronic Renal Insufficiency Cohort (CRIC) Study Group: Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. Journal of the American Medical Association, 305(23);2432-2439, 2011. (PMC3124770)

Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS for the CKD-EPI Investigators: Estimating glomerular filtration rate from serum creatinine and cystatin C. New England Journal of Medicine, 367:20-29, 2012.

Anderson AH, Yang W, Hsu C-Y, Joffe MM, Leonard MB, Xie D, Chen J, Greene T, Jaar BG, Kao P, Kusek JW, Landis JR, Lash JP, Townsend RR, Weir MR, Feldman HI for the CRIC Study Investigators: Estimating glomerular filtration rate among participants of the Chronic Renal Insufficiency Cohort (CRIC) Study. American Journal of Kidney Diseases, in press 2012.

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