The Center for Genetics and Complex Traits (CGACT) is a Type I Center of the Center for Clinical Epidemiology and Biostatistics. The theme of CGACT is to develop and apply epidemiological and statistical approaches that integrate knowledge from the human genome, basic molecular and cellular biology, biomedical informatics, behavioral science, bioethics and the clinical sciences to understand complex human disease traits.
These methods will be applied to study etiology and outcomes associated with cancer, sleep disorders, psychiatric disorders including addiction, obesity, diabetes, autoimmune disorders, asthma, cardiovascular disease, and others.
Cool New Science
- Jill S. Barnholtz-Sloan, Brian McEvoy, Mark D. Shriver, and Timothy R. Rebbeck, Ancestry Estimation and Correction for Population Stratification in Molecular Epidemiologic Association Studies. Cancer Epidemiol Biomarkers Prev 2008;17(3):471 – 7
- H. Zhang & K. Sol-Church & H. Rydbeck & D. Stabley &
L. D. Spotila & M. Devoto, High resolution linkage and linkage disequilibrium analyses of chromosome 1p36 SNPs identify new positional candidate genes for low bone mineral density. Osteoporos Int 2008 - Hashem B. El-Serag, Donna White, Nandita Mitra, Genetic Association Studies: From “Searching Under the Lamppost” to “Fishing in the Pond”. Gastroenterology 2008;134:662–664
- H Schelleman, Z Chen, C Kealey, AS Whitehead, J Christie, M Price, CM Brensinger,CW Newcomb, CF Thorn, FF Samaha and SE Kimmel Warfarin Response and Vitamin K Epoxide
Reductase Complex 1 in African Americans and
Caucasians
Nature 2007; Vol 81 (5) - Noah D. Kauff, Susan M. Domchek, Tara M. Friebel, Mark E. Robson, Johanna Lee, Judy E. Garber, Claudine Isaacs, D. Gareth Evans, Henry Lynch, Rosalind A. Eeles, Susan L. Neuhausen, Mary B. Daly, Ellen Matloff, Joanne L. Blum, Paul Sabbatini, Richard R. Barakat, Clifford Hudis, Larry Norton, Kenneth Offit, and Timothy R. Rebbeck Risk-Reducing Salpingo-Oophorectomy for the Prevention of BRCA1- and BRCA2-Associated Breast and Gynecologic Cancer: A Multicenter, Prospective StudyJournal of Clinical Oncology 2008 March; Vol 26 (8)
