Sean Hennessy, PharmD, PhD

Associate Professor of Epidemiology, Department of Biostatistics and Epidemiology
Associate Professor of Pharmacology, Department of Pharmacology
Senior Scholar, Center for Clinical Epidemiology & Biostatistics
Director of Ambulatory Drug Use and Effects, University of Pennsylvania Medical Center
Senior Fellow, The Leonard Davis Institute of Health Economics
Fellow, Institute on Aging
Associate Editor, Pharmacoepidemiology and Drug Safety

Education

BS (Pharmacy), University of the Sciences in Philadelphia
Doctor of Pharmacy, University of the Sciences in Philadelphia
Master of Science in Clinical Epidemiology, University of Pennsylvania School of Medicine
PhD (Epidemiology with Biostatistics Minor), University of Pennsylvania

Awards and honors

1998                Stanley Edlavitch Award for Best Abstract by a Student, International Society for Pharmacoepidemiology
2002                Saul Winegrad Award for Outstanding Dissertation in Epidemiology and Biostatistics, University of Pennsylvania
2005                Young Alumnus Award, University of the Sciences in Philadelphia

Bibliography

Peer-reviewed research publications

  1. Meropol SB, MD, Chan KA, Chen Z, Finkelstein JA, Hennessy S, Lautenbach E, Platt R, Schech SD, Shatin D, Metlay JP. Adverse events associated with prolonged antibiotic use. Pharmacoepdemiology and Drug Safety 2008;17:523-532.
  2. Haynes K, Hennessy S, Morales KH, Gibson GA, Barnhart C, Jaipaul CK, Linkin DR. Inter-rater reliability of a classification system for hospital adverse drug event reports. Clinical Pharmacology and Therapeutics 2008; 83:485-488.
  3. Haynes K, Heitjan D, Kanetsky P, Hennessy S. Declining public health burden of digoxin toxicity from 1991 to 2004. Clinical Pharmacology and Therapeutics 2008; 84:90-94.
  4. Leonard CE, Haynes K, Localio R, Hennessy S, Tjia J, Cohen A, Kimmel S, Feldman H, Metlay JP. Diagnostic E-codes for commonly-used, narrow therapeutic index medications poorly predict adverse drug events. Journal of Clinical Epidemiology 2008; 61:561-571.
  5. Hennessy S, Leonard CE, Palumbo CM, Newcomb C, Bilker WB.  Quality of Medicaid and medicare data obtained through CMS.  Medical Care 2007;45:1216-1220.
  6. Yang Y-X, Hennessy S, Propert K, Hwang W-T, Sedarat A, Lewis JD.  Chronic proton pump inhibitor therapy and the risk of colorectal cancer.  Gastroenterology 2007; 133:748-54.
  7. Hennessy S, Leonard CE, Bilker WB.  Researchers and HIPAA.  Epidemiology 2007;18:518.
  8. Hennessy S, Bilker WB, Leonard CL, Chittams J, Palumbo CM, Karlawish JH, Yang Y-X, Lautenbach E, Baine WB, Metlay JP. Antidepressant and pneumonia risk.  Journal of Clinical Epidemiology 2007;60:911e-918e.
  9. Mansson R, Sun W, Hennessy S, Joffe MM. On the estimation and use of propensity scores in case-control and case cohort studies. American Journal of Epidemiology 2007;165:1-8.
  10. Hennessy S, Leonard C, Yang W, Kimmel S, Townsend R, Wasserstein A, Ten Have T, Bilker W.  Effectiveness of a two-part educational intervention to improve hypertension control:  a cluster-randomized trial.  Pharmacotherapy 2006;26:1342-1347.
  11. Apter A, Kinman J, Bilker W, Herlim M, Margolis D, Lautenbach E, Hennessy S, Strom B. Is there cross-reactivity between penicillins and cephalosporins? American Journal of Medicine 2006;119:354e11-19.
  12. Ilkhanoff L, Lewis JD, Hennessy S, Berlin JA, Kimmel SE. Potential limitations of electronic database studies of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI). Pharmacoepidemiology & Drug Safety 2005:14:513-522.
  13. Metlay J, Cohen A, Polsky D, Kimmel S, Koppel R, Hennessy S. Medication safety among older adults: home based practice patterns.  Journal of the American Geriatrics Society 2005; 53(6): 976-982
  14. Yang Y-X, Hennessy S, Lewis JD. Type 2 Diabetes and risk of colorectal cancer.  Clinical Gastroenterology and Hepatology 2005; 3: 587-594.
  15. Halpern S, Barton T, Gross R, Hennessy S, Berlin J, Strom BL. Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reported. Pharmacoepidemiology and Drug Safety 2005: 14: 155-161.
  16. Yang Y-X, Hennessy S, Lewis JD.  Insulin therapy is associated with increased colorectal cancer risk among type 2 diabetes mellitus patients. Gastrtroenterology 2004;127:1044-1050
  17. Hennessy S, Bilker W, Knauss J, Kimmel S, Margolis D, Morrison M, Reynolds R, Glasser D, Strom B.  Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol. British Journal of Clinical Pharmacology 2004;58:81-87.
  18. Corren J, Manning BE, Thompson SF, Hennessy S, Strom BL.  Rhinitis Therapy and Risk for Hospital Care for Asthma: A Case-Control Study.  Journal of Allergy and Clinical Immunology 2004;113:415-419.
  19. Apter AJ, Kinman JL, Bilker WB, Herlim M, Margolis DJ, Lautenbach E, Hennessy S, Strom BL.  Re-prescription of pennicillin after allergic-like events.  Journal of Allergy and Clinical Immunology 2004;113:764-770.
  20. Weiner MG, Livshits A, Carozzoni C, McMenamin E, Gibson G, Loren AW, Hennessy S. Derivation of Malignancy Status from ICD-9 Codes.  Proceedings of the American Medical Informatics Association 2003;1050.
  21. Strom BL, Schinnar R, Apter AJ, Margolis DJ, Lautenbach E, Hennessy S, Bilker WB, Pettitt D.  Absence of Cross-Reactivity between Sulfonamide Antibiotics and Sulfonamide.  New England Journal of Medicine 2003;349:1628-1635.
  22. Hennessy S, Bilker WB, Weber A, Zhou L, Brensinger C, Wang Y, Strom BL. Restrospective Drug Utilization Review, Prescribing Errors, and Clinical Outcomes. Journal of the American Medical Association 2003;290:1494-99.
  23. Kimmel SE, Lewis J, Jaskowiak J, Kishel L, Hennessy S. Enhancement of Medication recall using medication pictures and lists in telephone interviews. Pharmacoepidemiology and Drug Safety 2003;12:1-8.
  24. Hennessy S, Bilker WB, Weber A, Strom BL. Descriptive analyses of the integrity of a US Medicaid claims database. Pharmacoepidemiology and Drug Safety 2003;12:103-111.
  25. Hennessy S, Bilker WB, Knauss JS, Margolis D, Kimmel SE, Reynolds RF, Glasser D, Morrison M, Strom BL. Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ 2002;325:1070-1075.
  26. Kimmel SE, Berlin J, Kinman J, Hennessy S, Feldman H, Carson J, Strom BL. Parenteral Ketorolac and risk of myocardial infarction. Pharmacoepidemiology and Drug Safety 2002;11, 113-119.
  27. Hennessy S, Berlin JA, Kinman JL, Margolis DJ, Marcus S, Strom BL. Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysis. Contraception 2001 64:125-133, August 2001.
  28. Margolis DJ, Bilker WB, Hennessy S, Vittorio C, Santanna J, Strom BL. The risk of malignancy associated with psoriasis. Archives of Dermatology 2001;137:778-783.
  29. Hennessy S, Bilker WB, Berlin JA, Strom BL. Factors influencing the optimal control-to-case ratio in matched case-control studies. American Journal of Epidemiology 1999;149:195-7 [published erratum appears in Am J Epidemiol 1999 Mar 1;149:489].
  30. Hennessy S, Kinman JL, Berlin JA, Carson JL, Kimmel SE, Farrar J, Harb G, Strom BL. Lack of hepatotoxicity of parenteral ketorolac in the hospital setting. Archives of Internal Medicine 1997;157:2510-2514.
  31. Liu Z-L, Hennessy S, Strom BL, Tsai TF, Wan C-M, Tang S-C, Xiang C-F, Bilker WB, Pan X P, Yau J-Y, Xu Z-W, Halstead SB. Short-term safety of live-attenuated Japanese encephalitis vaccine (SA14-14-2): Results of a randomized trial with 26,239 subjects. Journal of Infectious Diseases 1997;176:1366-69.
  32. Kimmel SE, Berlin JA, Hennessy S, Strom BL, Laskey WK. Risk of major complications from coronary angioplasty performed after diagnostic catheterization: Results from the registry of the Society for Cardiac Angiography and Interventions. Journal of the American College of Cardiology 1997;30:193-200.
  33. Feldman HI, Kinman JL, Berlin JA, Hennessy S, Kimmel SE, Farrar J, Carson JL, Strom BL. Parenteral ketorolac: the risk for acute renal failure. Annals of Internal Medicine 1997;126:193-199.
  34. Hennessy S, Liu Z, Tsai TF, Strom BL, Wan CM, Liu HL, Wu TX, Liu QM, Yu HJ, Halstead SB. Effectiveness of live-attenuated Japanese encephalitis vaccine (SA14-14-2): A case-control study. Lancet 1996;347:1583-86.
  35. Strom BL, Berlin JA, Kinman J, Spitz PW, Hennessy S, Feldman HI, Carson JL, Kimmel SE. Postmarketing surveillance study of parenteral ketorolac: Effects on gastrointestinal and postoperative bleeding. Journal of the American Medical Association 1996;275:376-382.
  36. Hennessy S, Strom BL, Berlin JA, Brennan PJ. Predicting Cutaneous hypersensitivity reactions to cotrimoxazole in HIV-infected individuals receiving primary Pneumocystis carinii pneumonia prophylaxis. Journal of General Internal Medicine 1995;10:380-386.
  37. Boyce EG, Montagne M, Reinsmith WA, Hennessy S, Knowlton CH. A cross-sectional study of the ethics of pharmacy students. Drug Intelligence and Clinical Pharmacy 1989;23:590 592.

Letters, reviews, and book chapters

  1. Norris NL, High K, Gill TM, Hennessy S, Kutner JS, Reuben DB, Unutzer J, Landefeld S.  Healthcare for older Americans with multiple chronic conditions:  a research agenda.  Journal of the American Geriatrics Society 2008;56:149-159.
  2. Hennessy S, Strom BL. PDUFA Reauthorization - Drug Safety’s Golden Moment of Opportunity? New England Journal of Medicine 2007;356:1703-1704.
  3. Hennessy S.  Use of health care databases in pharmacoepidemiology.  Basic and Clinical Pharmacoepidemiology and Toxicology 2006;98:311-313.
  4. Strom BL, Hennessy S.  “The future of pharmacoepidemiology.” In Strom BL (ed.) Pharmacoepidemiology, 4th ed. John Wiley, Chichester, 2005:833-841.
  5. Hennessy S, Carson JL, Ray WA, Strom BL. “Medicaid databases.” In Strom BL (ed.) Pharmacoepidemiology, 4th ed. John Wiley, Chichester, 2005:281-294.
  6. Hennessy S, Soumerai SB, Lipton HL, Strom BL “Drug utilization review.” In Strom BL, (ed.) Pharmacoepidemiology, 4th ed., John Wiley, Chichester, 2005:439-454.
  7. Henry DA, McGettigan P, Tonkin A, Hennessy S. “Basic principles of clinical pharmacology relevant to pharmacoepidemiology studies.” In Strom, BL (ed.) Pharmacoepidemiology, 4th edition, John Wiley, Sussex, 2005:37-58
  8. Hennessy S, Bilker WB, Weber A, Brensinger C, Strom BL.  Retrospective drug utilization review, prescribing errors, and clinical outcomes [letter].  Journal of the American Medical Association 2004;291:185-186.
  9. Hennessy S. Disproportionality analyses of spontaneous reports. [editorial]. Pharmacoepidemiology and Drug Safety 2004; 13:503-504.
  10. Hennessy S, Kimmel S. Is improved survival a class effect of angiotensin-converting enzyme inhibitors? [editorial]. Annals of Internal Medicine 2004;141:157-159.
  11. Strom BL, Hennessy H: Pharmacist Care and Clinical Outcomes for Patients With Reactive Airways Disease. Journal of the American Medical Association October 2002, 288:1642-1643.
  12. Hennessy S, Strom BL. Statins and fracture risk. Journal of the American Medical Association 2001;285:1888-9.
  13. Hennessy S, Strom BL. Non-sedating antihistamines should be preferred over sedating antihistamines in patients who drive. Annals of Internal Medicine 2000;132:405-7.
  14. Hennessy S. Potentially remediable features of the medication use environment in the US. American Journal of Health Systems Pharmacy 2000;57:543-548.
  15. Hennessy S. Postmarketing surveillance: An epidemiologic perspective. Clinical Therapeutics 1998;20(Suppl):C32-C39.
  16. Strom BL, Berlin JA, Kinman JL, Hennessy S, Feldman H, Kimmel SE, Carson JL. Risk of operative site bleeding with parenteral ketorolac . Journal of the American Medical Association 1996;276:372.
  17. Henry DA, Smith AJ, Hennessy S. Basic principles of clinical pharmacology relevant to pharmacoepidemiologic research. In: Strom, BL (ed.). Pharmacoepidemiology, 2nd edition, 1994; Sussex: John Wiley.
  18. Hennessy S. Book review of Epidemiology by Leon Gordis. Journal of General Internal Medicine 1996;11:777.
  19. Hennessy S, Strom BL. Issues in hospital-based drug use evaluation. P&T: A peer-reviewed journal for formulary management. 1992;17:733-754.
  20. Hennessy S, Fogarty PM, Schulman KA, Mignott H. Gastric obstruction with extended-release tablets. Annals of Pharmacotherapy. 1991; 25:678-679.
  21. Hennessy S, Nelson LA. Anaphylaxis and poisonings. American Druggist 1991;(C.E. Issue):42-52.

Contact information

Sean Hennessy, PharmD, PhD
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
803 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
USA

phone: +1 215 898 9112
fax: +1 215 573 5315
email: hennessy@mail.med.upenn.edu 

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