The nature of gene-drug interactions is complex, and thus requires true interdisciplinary approach, including open and sustained collaboration with and among the disciplines of genetics, bioinformatics, pharmacology, epidemiology, biostatistics, and bioethics.  Barriers to sustainable collaborations in the emerging field of Human Pharmacogenetic Epidemiology (HPE)are complex and include motivational, cultural, perceptional, territorial, and linguistic factors.

This proposal will seek to address these barriers to comprehensive HPE research by creating interdisciplinary educational content that can be applied to the following aims:

1.  Develop and implement the cross-disciplinary HPE seminar series
2.  Develop and implement one large “Grand Rounds style” lecture involving visiting leaders in the field of HPE
3.  Apply content from the HPE seminar series to a short course format for the Certificate Program in Clinical Research

This proposal will address the major goals of the P20 by addressing barriers to transdisciplinary research and involving
diverse researchers in the educational objectives.  The resultant material will generate situations to foster physical contact and intellectual interplay around focused topics and projects.  The major impact will be the breaking of barriers to foster future large collaborative research endeavors.