Investigators:
Kevin Haynes, PharmD (PI),
Sean Hennessy, PharmD, PhD, Peter Kanetsky, PhD, MPH, Hanna Rennert, PhD
Feasibility of Obtaining Genetic Samples
from Members of A Large
Medical Records Research Database in the
United Kingdom
The proposed
research in human pharmacogenomic
epidemiology will determine the feasibility of obtaining genetic
samples from
members of a large medical records research database in the United Kingdom. The project
will specifically address the logistical barriers in obtaining these
samples. The interdisciplinary nature of
the project involves the fields of pharmacoepidemiology and the
population
utilization of medication and pharmacogenetics.
The development of a mechanism to collect genetic samples from
large
research databases will greatly improve the coordination and efficiency
of
human pharmacogenomic epidemiology by enabling the study of larger
sample
sizes. The specific aim of the proposal
will test the difference in response rate between a group randomized to
receive
a 5 GBP voucher for participation verse a group randomized to receive
no
compensation. The proposal includes a
plan for a cross-disciplinary apprenticeship for the applicant in the
area of laboratory
DNA extraction. The applicant is a
clinical research pharmacist with an interest in pharmacoepidemiology
and
pharmacogenetics. The proposed
apprenticeship in the Molecular Diagnosis and Genotyping Facility will
enable
the applicant to gain an appreciation for the laboratory techniques
utilized in
genetics research and assist in future protocol development. The proposal may serve as the applicant’s
master’s thesis and will particularly assist the applicant in
collecting
necessary samples for an ongoing pharmacogenetic study involving
digoxin.