PROSE Study (Prevention and Observation of Surgical Endpoints)

The availability of genetic testing for inherited mutations in the BRCA1 and BRCA2 genes provides potentially valuable information to women at high risk of breast or ovarian cancer. Unfortunately, carriers of these mutations have relatively few clinical management options to reduce their cancer risk. The goal of the PROSE Study (Prevention and Observation of Surgical Endpoints) is to estimate breast and ovarian cancer risk reduction after the use of risk-reduction surgery and to evaluate psychosocial endpoints in women who carry BRCA1 and BRCA2 mutations.

MAGIC (Modifiers and Genetics in Cancer)

When a woman inherits a genetic defect in the BRCA1 or BRCA2 (BRCA1/2) genes, she may be at increased risk of developing breast and ovarian cancer. However, scientists are learning that cancer risk in these women may also be explained by other factors, including exposures, lifestyle, or other genes. Therefore, the goal of this research is to identify the factors that influence BRCA1/2-associated cancer risk.

The following specific aims of our research are:

  1. To study whether specific genes are associated with the characteristics of breast tumors when they are diagnosed;
  2. To study whether specific genes are associated with altered breast cancer risk;
  3. To determine whether specific genes predict whether a woman may be diagnosed with a breast cancer vs. ovarian and ovarian cancer.

The goal of this research is to improve our ability to assess cancer risk, understand the causes of these tumors, and improve our ability to prevent these cancers.

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