Model of Breast Carcinogenesis.
From: O'Connell et al. Department of Pathology
The University of Texas health Science Center at San Antonio.
1. Modifiers of Cancer Risk in Hereditary Breast Cancer: Using
a sample of BRCA1 and BRCA2 mutation carriers, we are studying the
role of genes at other loci and other risk factors in modifying the
incidence of breast and ovarian cancer.
2. Prophylactic Surgery: We are studying the role of prophylactic
surgery in reducing the incidence and and mortality from cancer in
carriers of BRCA1 or BRCA2 mutations.
3. Etiologic Heterogeneity in Late Onset Breast Cancer:
This study is addressing three specific hypotheses. First, we are
evaluating whether candidate susceptibility genotypes at the
cytochromes P450 and glutathione-S-transferase loci define
etiologically heterogeneous case groups with respect to age at breast
cancer diagnosis. Second, we are evaluating whether candidate
genotypes define etiologically heterogeneous case groups with respect
to somatic genetic damage. Third, we are evaluating whether
interactions of candidate susceptibility genotypes and somatic genetic
mutation define etiologically heterogeneous case groups.
4. Genotype-Hormone Interaction in Breast Cancer Susceptibility:
This is a population-based case-control study evaluating interactions
of hormonal factors (including reproductive events and exogenous
hormone exposures) and inherited genotypes that are involved in the
metabolism of hormones in breast cancer risk.
Collaborators:
Funding: Public Health Service Grants R01-CA73730,
R01-CA83855, P01-CA77596
M. Daly, A. Godwin (Fox Chase Cancer Center)
J. Garber, M. Brown (Dana-Farber Cancer Institute)
C. Lerman, C. Isaacs (Georgetown U.)
H. Lynch (Creighton U.)
S. Narod (Women's College Hospital/U. of Toronto)
S. Neuhausen (U. of Utah)
F. Olopade (U. of Chicago)
B. Strom, B. Weber (U. of Pennsylvania)
L. Van 't Veer (Netherlands Cancer Institute)
Ros Eeles (Royal Marsden Hospital)
Gareth Evans (Manchester NHS Trust)