Depiction of the of increase in melanoma incidence and mortality.
From: Douglas Reintgen, MD, Program Leader, Cutaneous Oncology,
H. Lee Moffitt Cancer Center & Research Institute Associate
Professor of Surgery, University of South Florida, Tampa, Florida.
Description: We are undertaking a case-control study that will
directly address the complex, multifactorial etiology of melanoma that
involves the interaction of genotypes and other risk factors. This
study is addressing a number of specific hypotheses. First, we are
evaluating whether candidate susceptibility genotypes at the
melanocortin 1 receptor (MC1R) gene are associated with
melanoma in a case-control analysis. Second, we are evaluating whether
genotypes at MC1R and other risk factors (e.g., dysplastic nevi, UV
sun exposure, hair/eye color) interact in melanoma etiology, and
whether knowledge of MC1R genotypes will improve our understanding of
melanoma etiology once these other risk factors are known. Third, we are
evaluating whether MC1R genotypes and other exposures distinguish
individuals with dysplastic nevi who do and do not eventually develop
invasive melanoma. Collaborators:
Funding: Public Health Service Grants P01-CA75434, U01-CA83180
The Pigmented Lesion Group (University of Pennsylvania)
M. Berwick, A. Halpern (Memorial Sloan-Kettering)
A. Goldstein, M.-T. Landi, M. Tucker (NCI)
