Faculty

Bruce L. Levine, Ph.D.

Barbara and Edward Netter Professor in Cancer Gene Therapy

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Center for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard
Philadelphia, PA 19104

Office: 215-746-1481

Email:
levinebl@pennmedicine.upenn.edu

Education
B.A. (Major-Biology, Minor-History)
The University of Pennsylvania , 1984.
Ph.D. (Immunology and Infectious Diseases)
The Johns Hopkins University, 1992.

Links
Clinical Cell and Vaccine Production Facility, Bruce Levine, Ph.D., Founding Director

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Immunology, Cell and Gene Therapy

Description of Other Expertise

Good Manufacturing Practices

Selected Publications

Golinelli, Giulia, Fan, Ting-Jia, Gabunia, Khatuna, Wilson, Wesley V., Assenmacher, Charles-Antoine, Xu, He N., Gonzalves, Diego, Castelli, Sofia, Reff, Jordan, Mai, David, Johnson, Omar, Ferraro, Zachary, Gupta, Aasha, Deshmukh, Mansi, Muthumani, Deeksha, Song, Decheng, Martinez, Daniel, Radaelli, Enrico, Verrelle, Jillian, Masciotta, Federica, Santori, Valentino, Liu, Shimin, Tchou, Julia, Dominici, Massimo, Young, Regina M., Rech, Andrew J., June, Carl H., Scholler, John, Levine, Bruce L.: Enhanced anti-tumor efficacy through combined CAR T cell therapy and CD40 stimulation in syngeneic solid tumor models. Cytotherapy Page: 102977, Aug 2026 Notes: https://doi.org/10.1016/j.jcyt.2026.102977.

Paruzzo L, Chong ER, Chong EA, Zheng Z, Guruprasad P, Landsburg DJ, Nasta SD, Stella F, Ramasubramanian R, de Souza VB, Alkhatib MH, Ho M, Imparato A, Chen GM, Siegel DL, Plesa G, Dai A, Mackey S, Das P, Michener P, Jadlowsky J, Bushman FD, Patel V, Carturan A, Napier EB, Gonzalez VE, Jarocha D, Xu R, Levine BL, Porazzi P, Frey N, Porter DL, Svoboda J, Fraietta JA, June CH, Schuster SJ, Ruella M.: Decade-long persistence of CD19 CAR T cells in B cell lymphomas. Nat Med Aug 2026.

Ruella M, Paruzzo L, Chong ER, Chong EA, Landsburg DJ, Nasta SD, Devi P, Michener P, Stella F, Carturan A, Napier EB, Van Deerlin VM, Porazzi P, Levine BL, Frey N, Porter DL, Fraietta JA, Svoboda J, June CH, Schuster SJ.: Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas. N Engl J Med 394: 2440-2448, Jun 2026.

Chen GM, Jain A, Gering DT, Satulovsky J, Datta S, Lai P, Karar J, Gonzalez VE, Alexander K, Chew A, Jadlowsky JK, Ruella M, Paruzzo L, Amses KR, Rech AJ, Stadtmauer EA, Frey NV, Hexner EO, Porter DL, Cohen AD, Gill SI, Garfall AL, Schuster SJ, Mo KC, Liang SI, Spasic M, Levine BL, Siegel DL, Ramírez-Fernández A, Cabanski CR, Yang E, Mackall CL, Bushman FD, Good Z, John Wherry E, June CH, Fraietta JA.: Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer. Nat Biomed Eng 10(4): 803-814, April 2026.

Rommel PC, Engel NW, Levine BL, June CH.: Efficient Production of Chimeric Antigen Receptor (CAR) T Cells with Transgenes Exceeding 10 kb Using Lentiviral Vectors. J Vis Exp (227, Jan 2026.

Rommel PC, Engel NW, Malachowski JK, Shukla D, Hodson IR, Gonzales D, van der Loo JCM, Young RM, Riley JL, Levine BL, June CH.: Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations. J Immunother Cancer 14: e012318, Jan 2026.

Tebas P, Jadlowsky JK, Zhou Y, Pampena MB, Leslie GJ, Liu N, Srivatsa S, Maldini CR, Wang J, Tsang CJ, Mohamed O, Romano J, Haggarty B, Plesa G, Gaymon AL, Brennan AL, Veloso E, Levine BL, Putt ME, Kulikovskaya I, Gonzalez V, Fraietta JA, Betts MR, Hoxie JA, Riley JL.: Clinical trial results provide the rationale to protect dual HIV-specific T cells with a signaling-defective HIV fusion inhibitor. Mol Ther Jan 2026.

Barber-Rotenberg JS, Haas AR, Aggarwal C, O'Hara M, Hexner E, Pequignot E, Dowd E, Ndeupen S, Thai E, Chen F, Oner BS, Czuczman C, Gonzalez VE, Fraietta JA, Hwang WT, Chew A, Jadlowsky JK, Marshall A, Shea KM, Jiang Y, Cosey A, Ferthio R, Levine BL, Plesa G, Siegel DL, Young RM, Sheppard NC, Albelda SM, June CH, Tanyi JL.: Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers. Mol Ther Jan 2026.

Ramírez-Fernández Á, Dimitri AJ, Chen F, Bartoszek R, Chen GM, Córdoba-Espejo L, Zhou Y, Tang YH, Lin CT, Acosta R, Scholler J, Ghilardi G, Porazzi P, Pellicer M, Profitós-Pelejà N, Barta SK, Chew A, Jadlowsky JK, Gonzalez VE, Siegel DL, Levine BL, Roué G, Ruella M, Lotze MT, June CH, Riley JL, Fraietta JA.: CCR5-targeted allogeneic gamma-delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy. Nat Biomed Eng Oct 2025.

Golinelli G, Scholler J, Roussel-Gervais A, Šakić A, Ilmjärv S, Song D, Gabunia K, Ji M, Fan TJ, Gupta A, Deshmukh M, Berjis A, Cuoghi Costantini R, Apodaca K, Sheppard NC, Kili S, Dominici M, Alessandrini M, June CH, Levine BL.: Multiplex engineering using microRNA-mediated gene silencing in CAR T cells. Front Immunol 16: 1647433, Aug 2025.