Faculty

Audrey Odom John, MD, PhD

Professor of Pediatrics (Infectious Diseases)

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Division of Infectious Diseases
10006 Colket Translational Research Building (CTRB)
3501 Civic Center Boulevard
Philadelphia, PA 19104

Office: 215-590-2457
Fax: 314-286-2895
Lab: 215-590-2382

Email:
johna3@chop.edu

Publications

Search PubMed for articles

Education
BS (Major Biology/minor Chemistry)
Duke University School of Medicine, 1996.
PhD (Biochemistry)
Duke University School of Medicine, 2002.
MD
Duke University School of Medicine, 2003.

Links
Search PubMed for articles
Google Scholar page for Audrey R. Odom John MD PhD
Odom John - laboratory website
Division of Infectious Diseases, Children's Hospital of Philadelphia

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Chief, Division of Infectious Diseases, Children's Hospital of Philadelphia

Description of Research Expertise

Dr. Odom John studies the malaria parasite, Plasmodium falciparum, to understand its basic molecular and cellular biology and functions of its specific metabolic pathways — what the parasite needs to make and why it needs to make it — to identify new antimalarial drug targets and develop new diagnostics.

Selected Publications

Hernandez-Leyva AJ, Berna AZ, Bui MH, Liu Y, Rosen AL, Lint MA, Whiteside SA, Jaeger N, McDonough RT, Joardar N, Santiago-Borges J, Tomera CP, Luo W, Odom John AR, Kau AL.: The gut microbiota shapes the human and murine breath volatilome. Cell Metab 38: 779-793, Apr 2026.

Sundararaman SA, Roper B, Davis AKF, Hanze Villavicencio KL, Mayhew JA, Wang ML, Tang NL, Soma VL, Wang Z, Feeney ME, Trehan I, Weatherhead JE, John CC, Gerber JS, Odom John AR.: Malaria in Children at 9 US Hospitals: 2016-2023. Pediatrics 157: e2025073556, Jun 2026.

Nelson JAD, Garfinkle SE, Lin ZJ, Park J, Kim AJ, Bayruns K, McCanna ME, Konrath KM, Agostino CJ, Kulp DW, Odom John AR, Pallesen J.: Machine learning enables de novo multiepitope design of Plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody. Proc Natl Acad Sci U S A 122: e2512358122, Dec 2025.

Guggisberg AM, Frasse PM, Jezewski AJ, Kafai NM, Gandhi AY, Erlinger SJ, Odom John AR: Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites. mBio 9(6): e01193-18, Nov 2018.

Sundararaman SA, Miller JJ, Daley EC, O'Brien KA, Kasak P, Daniels AM, Edwards RL, Heidel KM, Bague DA, Wilson MA, Koelper AJ, Kourtoglou EC, White AD, August SA, Apple GA, Rouamba RW, Durand AJ, Esteb JJ, Muller FL, Johnson RJ, Hoops GC, Dowd CS, Odom John AR.: Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH). Proc Natl Acad Sci U S A 122: e2417682122, Mar 2025.

Edwards, R. L., Heueck, I., Lee, S. G., Shah, I. T., Miller, J. J., Jezewski, A. J., Mikati, M. O., Wang, X., Brothers, R. C., Heidel, K. M., Osbourn, D. M., Burnham, C. D., Alvarez, S., Fritz, S. A., Dowd, C. S., Jez, J. M., Odom John, A. R.: Potent, specific MEPicides for treatment of zoonotic staphylococci. PLoS Pathog 16(6): e1007806, June 2020.

Brianne Roper, Deepika Kannan, Emily S. Mathews,Audrey R. Odom John : Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites. PLoS Pathogens 21: e1013313, July 2025 Notes: https://doi.org/10.1371/journal.ppat.1013313.

Chiotos, Kathleen, Bassiri, Hamid, Behrens, Edward M, Blatz, Allison M, Chang, Joyce, Diorio, Caroline, Fitzgerald, Julie C, Topjian, Alexis, John, Audrey R Odom: Multisystem Inflammatory Syndrome in Children during the COVID-19 pandemic: a case series. Journal of the Pediatric Infectious Diseases Society 9(3): 393-398, Jul 2020.

Amalia Z Berna, Tzvi Y Pollock, Yang Liu, Michelle Gibison, Amritha Mallikarjun, Joey Logan, Cynthia M Otto, Audrey R Odom John: Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling. mSphere. https://www.biorxiv.org/content/10.1101/2025.01.16.633338v1, 10: e0035125, Sep 2025.

Hernandez-Leyva AJ, Rosen AL, Tomera CP, Lin EE, Akaho EH, Blatz AM, Otto WR, Logan J, Young LR, Harris RM, Whiteside SA, Kau AL, Odom John AR.: Upper and lower airway microbiota across infancy and childhood. Pediatr Res Mar 2025.

Guggisberg AM, Sundararaman SA, Lanaspa M, Moraleda C, González R, Mayor A, Cisteró P, Hutchinson D, Kremsner PG, Hahn BH, Bassat Q, Odom AR: Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure with Fosmidomycin-Clindamycin. J Infect Dis 214(7): 1085-1091, Oct 2016.

Mikati, Marwa O., Miller, Justin J., Osbourn, Damon M., Ghebremichael, Naomi, Shah, Ishaan T., Burnham, Carey-Ann D., Heidel, Kenneth M., Yan, Victoria C., Muller, Florian L., Dowd, Cynthia S., Edwards, Rachel L., Odom John, Audrey R.: Antimicrobial prodrug activation by the staphylococcal glyoxalase GloB. ACS Infectious Diseases 6(11): 3064-3075, Nov 2020.

Schaber CL, Katta N, Bollinger LB, Mwale M, Mlotha-Mitole R, Trehan I, Raman B, Odom John AR: Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants. J Infect Dis 217(10): 1553-1560, Apr 2018.

Guggisberg AM, Sayler KA, Wisely SM, Odom John AR: Natural History of Plasmodium odocoilei Malaria Infection in Farmed White-Tailed Deer. mSphere 3(2): e00067-18, Apr 2018.

Mathews, Emily S., Jezewski, Andrew J., Odom John, Audrey R.: Protein prenylation and Hsp40 in thermotolerance of Plasmodium falciparum malaria parasites. mBio 12(3): e0076021, June 2021 Notes: https://doi.org/10.1101/842468.

Miller, J. J., Shah, I. T., Hatten, J., Barekatain, Y, Mueller, E.A., Moustafa, A.M., Edwards, R. L., Dowd, C. S., Planet, P.J., Muller, F.L., Jez, J. M., Odom John, A. R.: Structure-guided microbial targeting of antistaphylococcal prodrugs. eLife 10: e66657, Jul 2021 Notes: Submitted to bioRxiv: doi.org/10.1101/2020.12.

Elaina E. Lin, Elikplim H. Akaho, Anna Sobilo, Allison M. Blatz, William R. Otto, Audrey R. Odom John: Concordance of Upper and Lower Respiratory Tract Samples for SARS-CoV-2 in Pediatric Patients: Implications for Perioperative Diagnosis and Infection Control. Anesthesiology 134(6): 970-972, Apr 2021.

Nathan L'Etoile, Sesh A. Sundararaman, Erin Theiller, Justin J. Miller, Ahmed M. Moustafa, Andrew P. Steenhoff, Audrey R. Odom John: Pocapavir for neonatal enteroviral sepsis: limitations of rapid viral sequencing on treatment decisions. ASM Case Reports. ASM, 1: e00008-25, July 2025 Notes: https://doi.org/10.1128/asmcr.00008-25.