Faculty

Yanxiang Deng, PhD

Assistant Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact information

422 Curie Boulevard, Stellar-Chance Laboratories 713A
Philadelphia, PA 19104

Email:
Yanxiang.Deng@Pennmedicine.upenn.edu

Education:
PhD
Rensselaer Polytechnic Institute, 2018.

Links
Lab website

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Guo, P., Chen, Y., Mao, L., Cardilla, A., Lee, C., Cui, Y., Jin, D., Hua, Y., Xu, X., and Deng, Y.: Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues. Nature Communications Jul 2025.

Coleman, K., Schroeder, A., Loth, M., Zhang, D., Park, J. H., Sung, J. Y., ..., Deng, Y., …, and Li, M.: Resolving tissue complexity by multimodal spatial omics modeling with MISO. Nature Methods Jan 2025.

Guo, P., Mao, L., Chen, Y., Lee, C., Cardilla, A., Li, M., Bartosovic, M., and Deng, Y.: Multiplexed spatial mapping of chromatin features, transcriptome, and proteins in tissues. Nature Methods Jan 2025.

Lee, C., Fu, H., Cardilla, A., Zhou, W., and Deng, Y.: Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues. Nature in press 2025.

Farzad, N., Enninful, A., Bao, S., Zhang, D., Deng, Y., and Fan, R.: Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue. Nature Protocols Jun 2024.

Malik, S., Pradeep, S.P., Kumar, V., Xiao, Y., Deng, Y., Fan, R., Vasquez, J.C., Singh, V., and Bahal, R: Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor. Cell Reports Medicine Jan 2024.

Deng, Y.#*, Bai, Z.#*, Fan R.*: Microtechnologies for single-cell and spatial multi-omics. Nature Reviews Bioengineering Jun 2023.

Zhang, D.#, Deng, Y.#*, Kukanja P, Agirre E, Bartosovic M, Dong M, Ma C, Ma S, Su G, Bao S, Liu Y, Xiao Y, Rosoklija GB, Dwork AJ, Mann JJ, Leong KW, Boldrini M, Wang L, Haeussler M, Raphael BJ, Kluger Y, Castelo-Branco G*, Fan R.*: Spatially resolved epigenome-transcriptome co-profiling of mammalian tissues at the cellular level. Nature Mar 2023.

Wang, Y., Malik, S., Suh, H.W., Xiao, Y., Deng, Y., Fan, R., Huttner, A., Bindra, R.S., Singh, V., Saltzman, W.M. and Bahal, R.: Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances Feb 2023.

Liu, Y., DiStasio, M., Su, G., Asashima, H., Enninful, A., Qin, X., Deng, Y., Nam, J., Gao, F., Bordignon, P., Cassano, M., Tomayko, M., Xu, M., Halene, S., Craft, J., and Fan, R.: High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq. Nature Biotechnology Feb 2023.