Faculty

Haochang Shou, Ph.D.

Associate Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania

Department: Biostatistics and Epidemiology

Graduate Group Affiliations

Graduate Group in Epidemiology and Biostatistics

Contact information

Department of Biostatistics, Epidemiology and Informatics
University of Pennsylvania School of Medicine
D006 Richards Medical Research Laboratories
3700 Hamilton Walk
Philadelphia, PA 19104

Office: 215-573-6534

Email:
hshou@pennmedicine.upenn.edu

Education:
B.Sc. (Statistics)
Peking University, China, 2009.
Ph.D. (Biostatistics)
Johns Hopkins Bloomberg School of Public Health, 2014.

Links
The Penn Statistics in Imaging and Visualization Center (PennSIVE)

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Dr. Shou’s methodological research mainly focuses on functional data analysis with complex structures. She is particularly interested in novel statistical modeling and estimation techniques for multimodal functional and longitudinal measurements, including neuroimaging and human activity data. Her collaborations span brain disorder studies, mental health, and biomarker evaluation for chronic kidney disease.

Selected Publications

Zhang J, Cui E, Li H, Shou H.: INTACT: A method for integration of longitudinal physical activity data from multiple sources. Biometrics Nov 2025, accepted.

Tassopoulou V, Stamouli C, Shou H, Pappas GJ, Davatzikos C. : Uncertainty-calibrated prediction of randomly-timed biomarker trajectories with conformal bands. The Thirty-ninth Annual Conference on Neural Information Processing Systems (NeurIPS) Dec 2025 Notes: https://openreview.net/forum?id=jusQeCotOF.

Wen J, Skampardoni I, Tian YE, Yang Z, Cui Y, Erus G, Hwang G, Varol E, Boquet-Pujadas A, Chand GB, Nasrallah I, Satterthwaite TD, Shou H, Shen L, Toga AW, Zalesky A, Davatzikos C: Neuroimaging-AI endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders. Nat Biomed Eng 9(11): 1920-1937, Nov 2025.

Xiao W, Woodham RD, Cui Y, Wen J, Antoniades M, Srinivasan D, Fan Y, Erus G, Garcia JA, Arnott SR, Chen T, Choi KS, Chin Fatt C, Frey BN, Frokjaer VG, Ganz M, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Wei D, Anderson IM, Craighead WE, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C, Fu CHY.: Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics. Commun Med Nov 2025 Notes: doi: 10.1038/s43856-025-01219-5. Epub ahead of print.

Hu F, Ren Z, Chen L, Valcarcel AM, Dworkin J, Renner B, Daboul L, O'Donnell CM, Verter ED, Manning AR, Clark KA, Bae E, Chen C, Lou C, Satterthwaite TD, Shou H, Bilello M, Nakamura K, Bar-Or A, Calabresi PA, Freeman L, Henry RG, Longbrake EE, Oh J, Schindler MK, Absinta M, Solomon AJ, Sicotte NL, Ontaneda D, Reich DS, Sati P, Shinohara RT: Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers. Imaging Neurosci 3: IMAG.a.932, Oct 2025 Notes: doi:10.1162/IMAG.a.932.

Anagnostakis F, Kokkorakis M, Walker KA, Skampardoni I, Wen J, Erus G, Tosun D, Tassopoulou V, Cui Y, Govindarajan ST, Srinivasan D, Melhem R, Mamourian E, Shou H, Nasrallah IM, Mantzoros CS, Davatzikos C: Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy. EBioMedicine 116(105763), Jun 2025 Notes: doi:10.1016/j.ebiom.2025.105763.

Holmqvist S, Kaplan M, Chaturvedi R, Shou H, Giovannetti T: Longitudinal and combined smartwatch and ecological momentary assessment in racially diverse older adults: feasibility, adherence, and acceptability study. JMIR Hum Factors 12: e69952, Apr 2025.

Tassopoulou V, Shou H*, Davatzikos C*: Adaptive shrinkage estimation for personalized deep kernel regression in modeling brain trajectories. The Thirteenth International Conference on Learning Representations (ICLR) Apr 2025 Notes: https://openreview.net/forum?id=peX9zpWgg4. *co-senior authorship.

Xu H, Mu S, Bao J, Davatzikos C, Shou H*, Shen L* : High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy. BioData Mining 18(1): 24, Mar 2025 Notes: doi: 10.1186/s13040-025-00432-1. *co-senior authorship.

Govindarajan, S. T., Mamourian, E., Erus, G., Abdulkadir, A., Melhem, R., Doshi, J., Pomponio, R., Tosun, D., Bilgel, M., An, Y., Sotiras, A., Marcus, D. S., LaMontagne, P. J., Benzinger, T., Espeland, M. A., Masters, C. L., Maruff, P., Launer, L. J., Fripp, J., Johnson, S. C., Morris, J. C., Albert, M., Bryan, N., Resnick, S., Habes, M., Shou, H., Wolk, D., Nasrahllah, I., Davatzikos, C: Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals. Nat Commun 16(1): 2724, Mar 2025 Notes: doi: 10.1038/s41467-025-57867-7.