Faculty

Jonathan J Edwards, MD

Assistant Professor of Pediatrics (Cardiology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3401 Civic Center Blvd
Philadelphia, PA 19104

Education:
BS (Biology and Chemistry)
East Carolina University , 2008.
MD
Wake Forest School of Medicine , 2013.

Links
Edwards Laboratory for Pediatric Heart Failure
Prosser lab
Arany Lab

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Pediatric Cardiomyopathy, Heart Failure, and Transplantation

Description of Research Expertise

Right Ventricular Failure

Selected Publications

Lavine K, Kadyrov F, Amrute J, Kuznetsov I, Li K, Arany Z, Edwards J, Sucharov C, Miyamoto S: Cellular and Transcriptional Landscape of Human Hypoplastic Left Heart Syndrome. Res Sq May 2025.

Wooster L, O'Connor MJ, Zhang X, Mavroudis CD, Maeda K, Ahmed H, Edwards J, Lin KY, Wittlieb-Weber C, Rossano JW, Edelson JB: Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy. Circulation March 2025.

Hartman H, Uy G, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Kavar SL, Brandimarto J, Li L, Lai L, Griffin J, Yucel N, Shewale S, Rajagopal H, Eaton DM, Dorwart T, Bedi KC, Conn CS, Margulies K, Prosser B, Arany Z, Edwards JJ: ROR2 drives right ventricular heart failure via disruption of proteostasis. bioRxiv February 2025.

Forelli N, Eaton D, Patel J, Bowman CE, Kawakami R, Kuznetsov IA, Li K, Brady C, Bedi K, Yang Y, Koya K, Megill E, Kanter DS, Smith LG, Bowman GR, Snyder N, Edwards J, Margulies K, Arany Z: SGLT2 inhibitors activate pantothenate kinase in the human heart. bioRxiv July 2024.

Mavroudis CD, O'Connor MJ, Wittlieb-Weber C, Edelson JB, Edwards JJ, Berger JH, Lin KY, Rossano J, Maeda K: Hybrid stage 1 palliation with simultaneous off-pump ventricular assist device placement in neonates with high-risk single ventricle anatomy: Initial experience. JTCVS Tech April 2024.

Holzhauser L, Reza N, Edwards JJ, Birati EY, Owens AT, McLean R, Maeda K, O’Connor MJ, Rossano JW, Mondal A, Katcoff H, Edelson JB.: Emergency Department Use and Hospital Mortality Among Heart Transplant Recipients in the United States. J Am Heart Assoc. 2024.

Edwards JJ, Uy G, Hartman H, Uchida K, Scarborough EA, Yang Y, Barr E, Williams S, Brandimarto J, Li L, Yucel N, Eaton D, Conn C, Bedi K, Margulies K, Prosser B, Arany Z. : ROR2 Drives Right Ventricular Failure Via Proteostatic Imbalances. American Heart Association BCVS Scientific Sessions. 2024.

Edwards JJ, Hartman H, Barr E, Kuznetsov I, Li K, Yang Y, Bedi Ken, Margulies KB, Arany Z: Ventricular-specific proteomic analysis of human heart failure. American Society of Clinical Investigators: Joint Meeting. 2024.

Restaino K, Zhang X, Faerber JA, Rossano JW, Burstein D, Wittlieb-Weber CA, Lin KY, Edelson JB, Edwards JJ, O'Connor MJ.: Temporal trends in primary payers in pediatric heart transplant and association with long-term survival. Pediatr Transplant. 27(3): e14484, Feb 2023.

Edelson JB, Zhang X, Goldstone AB, Rossano JW, O'Connor MJ, Gaynor JW, Edwards JJ, Wittlieb-Weber C, Maeda K.: Reduced incidence of cardiac rejection in multi-organ transplants: A propensity matched study. Clin Transplant 2023.