Faculty

Jonathan J Edwards, MD

Assistant Professor of Pediatrics (Cardiology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3401 Civic Center Blvd
Philadelphia, PA 19104

Education
BS (Biology and Chemistry)
East Carolina University , 2008.
MD
Wake Forest School of Medicine , 2013.

Links
Edwards Laboratory for Pediatric Heart Failure
Prosser lab
Arany Lab

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Pediatric Cardiomyopathy, Heart Failure, and Transplantation

Description of Research Expertise

Right Ventricular Failure

Selected Publications

Uchida K, Scarborough EA, Pruzinsky E, Stone KR, Hartman H, Kelly DP, Edwards JJ, Kehat I, Prosser BL.: mTORC1 and nuclear ERK spatially control translation in cardiomyocytes through 4EBP1 phosphorylation. Sci Signal 21;19(934), Apr 2026

Zhao W, Zhu W, Thome T, Soaita I, Jung JW, Noji MC, Li J, Bai H, Xiao Y, Yang Y, Thorsheim C, Zhou W, Yang Y, Li K, Edwards JJ, Kuznetsov IA, Kim B, Baur JA, Arany Z.: NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis. Cell Metab. Apr 2026

Chaudhary AA, Srinivasan C, Maeda K, DeWitt AG, Montgomery C, Rastogi R, O'Connor MJ, Edwards JJ, Ahmed H, Lin KY, Rossano JW, Wittlieb-Weber C, Edelson JB: Cardiac Resynchronization Therapy to Aid Ventricular Assist Device Explantation in Infants with Cardiomyopathy and Left Bundle Branch Block. Pediatr Cardiol 47(5):2265-2268, June 2026.

Vite A, Guo T, Bouhrira N, Eaton DM, Bedi KC Jr, Brady CF, Edwards JJ, Duric B, Uchida K, Olsen C, Dong L, Prosser BL, Arany Z, Margulies KB.: Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes. Cell Rep 22;45(7):11757, June 2026.

Kuznetsov IA, Li K, Yang Y, Zhao W, Zhou W, Zhu W, Liang J, Li J, Edwards JJ, Arany Z.: Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation. bioRxiv June 2026.

Edwards JJ, Edelson JB, Rossano JW.: RNA-Based Therapies for Treating Monogenic Cardiomyopathies. Can J Cardiol. 42(5):967-981, May 2026.

Masood IR, Wang L, Stanley HM, Edwards JJ, Ahmed H, Lin KY, Wittlieb-Weber CA, O'Connor MJ, Rossano JW, O'Malley S, Paridon SM, Tam VW, Edelson JB.: Impact of Neighborhood Factors on Exercise Capacity in Children With Hypertrophic Cardiomyopathy. Circ Heart Fail 18(7):e012501, July 2025

O'Connor MJ, Vu C, Zhang X, Bennett L, Ahmed H, Edwards JJ, Lin KY, Li Y, Maeda K, Marcellus B, Monos D, Rossano JW, Wittlieb-Weber CA, Edelson JB.: Allosensitization status predicts excess mortality in pediatric congenital heart disease transplant recipients in the current era: An analysis of the United Network for Organ Sharing database. JHLT Open 10:100406, Nov 2025.

Lavine K, Kadyrov F, Amrute J, Kuznetsov I, Li K, Arany Z, Edwards J, Sucharov C, Miyamoto S: Cellular and Transcriptional Landscape of Human Hypoplastic Left Heart Syndrome. Res Sq Page: doi: 10.21203/rs.3.rs-6689087/v1, May 2025.

Wooster L, O'Connor MJ, Zhang X, Mavroudis CD, Maeda K, Ahmed H, Edwards J, Lin KY, Wittlieb-Weber C, Rossano JW, Edelson JB: Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy. Circulation 151(12): 814-824, March 2025 Notes: doi: 10.1161/CIRCULATIONAHA.124.072335.