Faculty

Kristopher R. Bosse, MD

Assistant Professor of Pediatrics (Oncology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104

Office: 651-492-6726
Fax: 267-426-0685

Email:
bossek@chop.edu

Education
AB (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania , 2010.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Pan H, Nelson B, Joshi N, Roth SL, Harvey K, Pascual-Pasto G, McDaid KS, Assenmacher CA, Schürch PM, Zecchino VP, Liu J, Yu J, Madsen PJ, Bosse KR*, Foster JB*. *, these authors contributed equally : Locoregional delivery of GPC2 CAR T cells is safe and effective in preclinical models of pediatric central nervous system tumors. Neuro-oncology 2(3): doi.org/10.1093/neuped/wuag038, July 2026.

Zhang H-F, De-Dreuzy E, Huang YZ, Shin S, Huang Q, Delaidelli a , Yang X , Adamiak V , Lytle1 A, Arzoo A , Lizardo MM, Lin Q, Rouleau M, Liu L , Xu L-Y, Li W , Lai R, Primus C, Sayed SRE, Bourhis L, Genin D, Demontrond L, Bouquet L, Demolis L, Barberot A, Lameynardie S, Delabrière A, Hua H, Yang J, Ishima R, Imle R, Banito A, Savage KJ, Maris JM, Bosse KR, Dimitrov D, Steidl C, Li W, Sainson RCA, Sorensen PH: IL1RAP antibody-drug conjugates potently target primary and metastatic disease in multiple oncofusion-driven cancers. Cancer Discovery Page: doi: 10.1158/2159-8290.CD-25-1036, April 2026.

Spear TT (presenter), Hartnett N, Posthill E, Groff D, Samanta M, Al-Halawani D, O’Reilly K, Kapoor R, Want M, Wang T, Liu L, Wang R, Madnick R, Shkundina I, Bosse KR, Alameh, MG, Weissman D, Maris JM: Epitope-encoded mRNA-LNP vaccine to enhance anti-tumor potency and persistence of PHOX2B peptide-centric CAR T cells. Poster presented at the American Association of Cancer Research Annual Meeting, San Diego, CA. *Meritorious Poster Award April 2026.

Schuerch PM (presenter), Draper B, Zecchino VP, Pan H, Nelson B, Giudice AM, Foster JB, Donovan LK, Bosse KR : Co-targeting GPC2 and B7-H3 with CAR T cells achieves durable responses in preclinical high-risk neuroblastoma and medulloblastoma models. Talk presented at the American Association of Cancer Research Annual Meeting, San Diego, CA. April 2026.

Brosius SN, Sussman JH, DiStefano IA, Grothusen GP, Natan KN, Seka I, Foltz S, Labella K, Dr. Bosse KR, Tan K, De Raedt T: Identification of CD74-positive antigen presenting glioma cells in primary human tumors and murine models of NF1 high-grade glioma. Molecular Cancer Therapeutics Page: doi: 10.1158/1535-7163.MCT-25-1215, April 2026.

Schuerch P (presenter), Zecchino VP, Giudice AM, Kaufman RS, Cresswell-Clay E, Pascual-Pasto G Roth SL, McIntyre BC, Shraim R, Hamilton AK, Parikh K, Conkrite KL, Trang KB, Grothusen GP, Groff D, Mishra P, Lombardi S, Skinner T, Wells AD, Grant SF, Martinez D, Li W, Diskin SJ, Bosse KR: Selective targeting of the α3β4 nicotinic acetylcholine receptor by DISCO (dual interacting subunit complex) CAR T cells. Talk presented at the American Association of Cancer Research Annual Meeting, San Diego, CA. April 2026.

Fraietta JA, Minehart J, and Bosse KR.: Rewiring Immunotherapy for High-Risk Neuroblastoma. Virtual, ImmunoLogic, Episode 9 March 2026.

Giudice AM, Matlaga S, Roth SL, Gladney W, Groff D, Hofmann TJ, Pascual-Pasto G, McIntyre B, Zecchino V, Martinez D, Spear TT, Wolpaw A, Assenmacher CA, Radaelli E, Pogoriler J, Pawel B, Barrett D, Grupp SA, Maris, JM, Bosse KR: D3-GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma and small cell lung cancer. Clinical Cancer Research 31(24): 5276-5293, December 2025.

Pan H, Foster J, Bosse KR: Scratching the surface of targeting GPC2 in pediatric CNS tumors. Molecular Therapy Oncology 33(4): 201102. doi: 10.1016/j.omton.2025.201102, December 2025.

Giudice AM, Matlaga S, Roth SL, Pascual-Pasto G, Schürch P, Rouin G, McIntyre B, Grothusen GP, Cresswell-clay E, Shraim R, Groff D, Zecchino V, Lombardi S, Martinez D, Spruce LA, Brown EM, Fazelinia H, Henrickson SE, Nance J, Reynolds CP, Bosse KR : Target antigen-displaying extracellular vesicles boost CAR T cell efficacy in cell and mouse models of neuroblastoma. Science Translational Medicine 17(825): eads4214. doi: 10.1126/scitranslmed.ads4214, November 2025.