Faculty

Zev Binder, M.D., Ph.D.

Research Assistant Professor of Neurosurgery

Department: Neurosurgery

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

3600 Hamilton Walk
Stemmler Hall
Philadelphia, PA 19104

Office: 215-573-0837

Email:
Zev.Binder@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
BS (Biochemistry)
University of California, Davis, 2004.
M.D.
Pennsylvania State University College of Medicine, 2008.
Ph.D. (Chemical and Biomolecular Engineering)
Johns Hopkins University, 2014.

Links
Search PubMed for articles
O'Rourke Laboratory Website
University of Pennsylvania's Center for Cellular Immunotherapies

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Dr. Binder is a Research Assistant Professor, working with Dr. O'Rourke since 2015. He received a B.S. degree in Biochemistry from the University of California at Davis, an M.D. from Pennsylvania State University, and a Ph.D. in Chemical and Biomolecular Engineering from Johns Hopkins University. Dr. Binder's research focuses on translational GBM research with an emphasis on immuno-oncology. He also works on GBM model development, characterization, and incorporation into the ongoing research.

Selected Publications

Zev A. Binder, Stephen J. Bagley, Jessica B. Foster & Donald M. O’Rourke: The development of CAR T cells for patients with CNS malignancies. Nature Reviews Clinical Oncology Dec 2025.

Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R. McKnight, Thomas P. Keeley,Katelyn A. Bustin, Eric W. Barr, Snehil R. Chilkamari, Mahaa Ayub, Sun Woo Kim,Zongtao Lin, Ren- Ming Hu, Kelly Hicks, Xie Wang, Donald M. O’Rourke,J. Martin Bollinger Jr., Zev A. Binder, William H. Parsons, Kirill A. Martemyanov,Aimin Liu, Megan L. Matthews: Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma. Science Advances 11(42), Oct 2025.

Erica L Carpenter, Jacob E Till, Dominique Ballinger, Camilla Macia, Carlos Leche, Melinda Yin, Arati S Desai, Timothy Prior, Maikel Mansour, Emily McCoy, Thara Patel, Shivani Shah, H Isaac Chen, Eric Zager, Christina Jackson, Steven Brem, Zev A Binder, Donald M O'Rourke, Nduka Amankulor, Nike Beaubier, Stephen J Bagley: Next-Generation Sequencing of Intraoperatively Acquired Cerebrospinal Fluid and Matched Tumor Tissue in Patients Undergoing Surgical Resection for Glioblastoma. JCO Precision Oncology September 2025.

Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari & C. Ryan Miller: Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. Acta Neuropathologica Communications June 2025 Notes: DOI https://doi.org/10.1186/s40478-025-02068-y.

Stephen J. Bagley, Arati S. Desai, Joseph A. Fraietta, Dana Silverbush, Daniel Chafamo, Nelson F. Freeburg, Gayathri Konanur Gopikrishna, Andrew J. Rech, Ali Nabavizadeh, Linda J. Bagley, Jungmin Park, Danuta Jarocha, Rene Martins, Nicolas Sarmiento, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel M. Leskowitz, Julie K. Jadlowsky, Shane Mackey, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, David Barrett, Robert Colbourn, MacLean P. Nasrallah, Zissimos Mourelatos, Wei-Ting Hwang, Cecile Alanio, Donald L. Siegel, Carl H. June, Elizabeth O. Hexner, Zev A. Binder & Donald M. O’Rourke: Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial. Nature Medicine June 2025.

Fathi Kazerooni A, Akbari H, Hu X, Bommineni V, Grigoriadis D, Toorens E, Sako C, Mamourian E, Ballinger D, Sussman R, Singh A, Verginadis II, Dahmane N, Koumenis C, Binder ZA, Bagley SJ, Mohan S, Hatzigeorgiou A, O'Rourke DM, Ganguly T, De S, Bakas S, Nasrallah MP, Davatzikos C. : The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers. Communications Medicine 5(1), March 2025.

Sabrina L. Begley, Donald M. O’Rourke, and Zev A. Binder: CAR T cell therapy for glioblastoma: A review of the first decade of clinical trials. Molecular Therapy March 2025.

Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Park KH, Dong W, Hung YF, Yang Q, Zhang F, Rajamani K, Mu S, Kennedy BC, Hong Y, Galanaugh J, Sambangi A, Kim SH, Wheeler G, Gonçalves T, Wang Q, Geschwind DH, Kawaguchi R, Viaene AN, Helbig I, Kessler SK, Hoke A, Wang H, Xu F, Binder ZA, Isaac Chen H, Pai EL, Stone S, Nasrallah MP, Christian KM, Fuccillo M, Toni N, Wu Z, Cheng HJ, O'Rourke DM, Ma M, Ming GL, Song H. : Brain-wide neuronal circuit connectome of human glioblastoma. Nature Jan 2025.

Till JE, Seewald NJ, Yazdani Z, Wang Z, Ballinger D, Samberg H, Dandu S, Macia C, Yin M, Abdalla A, Prior T, Shah S, Patel T, McCoy E, Mansour M, Wills CA, Bochenek V, Serrano J, Snuderl M, Phillips RE, O'Rourke DM, Amankulor NM, Nabavizadeh A, Desai AS, Gollomp K, Binder ZA, Zhou W, Bagley SJ, Carpenter EL: Corticosteroid-Dependent Association between Prognostic Peripheral Blood Cell-Free DNA Levels and Neutrophil-Mediated NETosis in Patients with Glioblastoma. Clinical Cancer Research Jan 2025.

Meghan Logun, Xin Wang, Yusha Sun, Stephen J Bagley, Nannan Li, Arati Desai, Daniel Y Zhang, MacLean P Nasrallah, Emily Ling-Lin Pai, Bike Su Oner, Gabriela Plesa, Donald Siegel, Zev A Binder*, Guo-Li Ming*, Hongjun Song*, Donald M O'Rourke*: Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy. Cell Stem Cell S1934-5909(24): 00409-0, Dec 2024 Notes: * co-senior author.