Faculty

Raiees Ahmad Andrabi, PhD

Associate Professor of Medicine (Infectious Diseases)

Department: Medicine

Graduate Group Affiliations

Contact information

Division of Infectious Diseases
Perelman School of Medicine
University of Pennsylvania
522E Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104

Lab: 215-573-5041

Publications

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Education
B.Sc. (Biology)
University of Kashmir, Srinagar, India, 2005.
M.Sc (Biochemistry)
Hamdard University, New Delhi, India, 2007.
PhD (Biochemistry/Philosophy)
All India Institute of Medical Sciences (AIIMS) New Delhi, India, 2012.

Links
Search PubMed for articles
Andrabi Laboratory Website

Permanent link

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Description of Research Expertise

The overarching goal of the Andrabi laboratory is to design vaccine immunogens and strategies that elicit protective broadly neutralizing antibody (bnAb) responses against viruses with complex glycoprotein surfaces—and to translate these into effective human vaccines. We focus on two main areas: 1) Structure-guided immunogen design—leveraging structure- and in vitro directed evolution guided strategies to develop vaccines targeting challenging viral surface antigens, including those from HIV, arenaviruses, and coronaviruses. 2) B cell immunobiology—deciphering the affinity maturation pathways required for bnAb development during infection and vaccination, with the aim of guiding next-generation vaccine design.

Selected Publications

Mishra N, Liang B, Roark RS, Ghosh AR, Callaghan S, Lee WH, Li X, Vo AL, Avillion G, Chowdhury RR, Habib R, Bibollet-Ruche F, Giese G, Oberoi P, Amereh K, Somanathan A, Zhu Y, Zhang Y, Kassab M, Tjio L, Andrabi S, Reyes RA, Allen JD, James NE, Randall KN Jr, van der Maas L, Ben-Akiva E, Kacmarek-Michaels K, Plante S, Martella CL, Skelly AN, Singh A, Hurtado J, Dueker K, Capozzola T, Nedellec R, Ozorowski G, Lewis MG, Falcone S, Carfi A, Himansu S, Shapiro L, Crispin M, Hahn BH, Briney B, Irvine DJ, Burton DR, Ward AB, Batista FD, Kwong PD, Shaw GM, Andrabi R.: Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques. Immunity 59: 1140-1160, Apr 2026.

Liang B, Zhu Y, Roark RS, Li X, Mishra N, Martella CL, Vo AL, Giese G, Huang Q, Biju A, Tjio L, Chowdhury RR, Oberoi P, Amereh K, Wani AA, Zhang Y, Andrabi S, Sekar TV, Somanathan A, Kassab M, Nedellec R, Callaghan S, Avillion G, Lewis MG, Sackett SD, Skelly AN, Bibollet-Ruche F, Shapiro L, Sheng Z, Briney B, Hahn BH, Burton DR, Irvine DJ, Kwong PD, Shaw GM, Andrabi R.: Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization. bioRxiv Mar 2026.

Ghosh AR, Habib R, Mishra N, Roark RS, Akauliya M, Albowaidey AA, Allen JD, Amereh K, Avillion G, Bottermann M, Liang B, Chaudhary N, Callaghan S, Dye J, Li X, Ellis-Pugh JR, Roy Chowdhury R, James NE, Liu X, Maiorino L, Villavicencio PM, Nedellec R, Oberoi P, Sowers KJ, Park Y, Prum T, Rodriguez L, Ssozi M, Torres JL, Walsh AA, Warner JE, Weldon SR, Xu L, Wiehe K, Crispin M, Ward AB, Nair U, Hahn BH, Burton DR, Shapiro L, Kwong PD, Irvine DJ, Andrabi R, Shaw GM, Batista FD.: Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization. Sci Immunol 11: eadz5064, Feb 2026.

Zhou P, Feng Z, He WT, Zhu Y, Yuan M, Li X, Zhang Y, Vo L, Capozzola T, Callaghan S, Mishra N, Avillion G, Dueker K, Liang B, Roy Chowdhury R, Nedellec R, Lee WH, Allen JD, Walsh A, Melo M, McAnarney ET, Kumar NA, Rinaldi W, Ferguson M, Crispin MM, Ward AB, Irvine DJ, Alameh MG, Weissman D, Baric RS, Gralinski LE, Wilson IA, Burton DR, Andrabi R.: Protective pan-betacoronavirus neutralizing antibodies by vaccination. bioRxiv Aug 2026.

Dueker K, Capozzola T, Feng Z, Lin RN, Hurtado J, Bangaru S, Yuan M, Beutler N, Garcia E, He WT, Callaghan S, Avillion G, Vo L, Li X, Torres JL, Musharrafieh R, Song G, Mishra N, Sharma P, Yong P, Anzanello F, Kaczmarek Michaels K, Ben-Akiva E, Silva M, Melo M, Makhdoomi M, Westfall-Gomez E, Rinaldi W, Ferguson M, Safonova Y, Crotty S, Irvine DJ, Rogers T, Ward AB, Briney B, Wilson IA, Burton DR, Andrabi R.: Heterologous betacoronavirus spike immunization in non-human primates elicits antibodies that neutralize both sarbeco- and merbecoviruses. Cell Rep 45: 117439, Jun 2026.

Zhou P, Song G, He WT, Beutler N, Tse LV, Martinez DR, Schr A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Yuan M, Liu H, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Wilson IA, Safonova Y, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R.: Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease. Immunity 56(3): 669–686, Mar 2023.

Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R: A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. Science Translational Medicine 14(637): 8, Feb 2022.

Song G, He WT, Callaghan S, Anzanello F, Huang D, Ricketts J, Torres JL, Beutler N, Peng L, Vargas S, Cassell J, Parren M, Yang L, Ignacio C, Smith DM, Voss JE, Nemazee D, Ward AB, Rogers T, Burton DR, Andrabi R.: Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection. Nat Commun 12(2938): 2938, May 2021.

He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Sch�r A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R.: Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses. Nat Immunol 23(1): 960-970, June 2022.

Song G, Yuan M, Liu H, Capozzola T, Lin RN, Torres JL, He WT, Musharrafieh R, Dueker K, Zhou P, Callaghan S, Mishra N, Yong P, Anzanello F, Avillion G, Vo AL, Li X, Zhang Y, Makhdoomi M, Feng Z, Zhu X, Peng L, Nemazee D, Safonova Y, Briney B, Ward AB, Burton DR, Wilson IA, Andrabi R.: Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift. Cell Rep 44: 115948, Jul 2025.

He WT, Yuan M, Callaghan S, Musharrafieh R, Song G, Silva M, Beutler N, Lee WH, Yong P, Torres JL, Melo M, Zhou P, Zhao F, Zhu X, Peng L, Huang D, Anzanello F, Ricketts J, Parren M, Garcia E, Ferguson M, Rinaldi W, Rawlings SA, Nemazee D, Smith DM, Briney B, Safonova Y, Rogers TF, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Irvine DJ, Ward AB, Wilson IA, Burton DR, Andrabi R.: Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Sci Transl Med 14(657): eabl9605, Aug 2022.