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Mohammad Haj Dezfulian, PhD
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Assistant Professor of Pathology and Laboratory Medicine
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Department: Pathology and Laboratory Medicine
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Graduate Group Affiliations
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- Cell and Molecular Biology 5c
- Immunology e
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Publications
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Education:
21 a B.Sc. 2b (Molecular Biology and Genetics) c
3f Tehran University & Chamran University, 2006.
21 8 PhD 2b (Molecular Biology and Genetics) c
2e University of Windsor, 2014.
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21 a B.Sc. 2b (Molecular Biology and Genetics) c
3f Tehran University & Chamran University, 2006.
21 8 PhD 2b (Molecular Biology and Genetics) c
2e University of Windsor, 2014.
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Links
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a6 Department of Pathology and Laboratory Medicine Profile b
96 The Institute for Immunology and Immune Health Profile
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Permanent linkb3 Search PubMed for articles
5d Haj-Dezfulian Lab Website
a6 Department of Pathology and Laboratory Medicine Profile b
96 The Institute for Immunology and Immune Health Profile
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Description of Research Expertise
201 Our laboratory investigates the molecular drivers of immune recognition across autoimmunity, malignancy, and infectious disease. We combine systems immunology with functional genomics and protein engineering to develop high-throughput technologies capable of mapping T cell specificity within patient samples. This engineering-driven approach enables us to elucidate the governing principles of immune specificity and tolerance, ultimately guiding the design of novel immunotherapeutic modalities.e 29
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1dd Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. : TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell 186(25): 5569-5586.e21, December 2023 Notes: doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27.
14e Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.: T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 178(4): 1016-1028.e13, August 2019 Notes: doi: 10.1016/j.cell.2019.07.009.
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Selected Publications
171 Kohlgruber AC, Dezfulian MH, Sie B, Wang CI, Kula T, Laserson U, Larman HB, Elledge SJ.: High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits. Nat Biotechnol no volume(no issue), July 2024 Notes: https://doi.org/10.1038/s41587-024-02248-6.1dd Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. : TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell 186(25): 5569-5586.e21, December 2023 Notes: doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27.
14e Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.: T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 178(4): 1016-1028.e13, August 2019 Notes: doi: 10.1016/j.cell.2019.07.009.
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