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Zissimos Mourelatos, M.D.
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Professor of Pathology and Laboratory Medicine
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Department: Pathology and Laboratory Medicine
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Graduate Group Affiliations
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Contact information
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Department of Pathology and Laboratory Medicine
22 Division of Neuropathology
20 613B Stellar Chance Labs
3b 422 Curie Boulevard
Philadelphia, PA 19104-6100
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22 Division of Neuropathology
20 613B Stellar Chance Labs
3b 422 Curie Boulevard
Philadelphia, PA 19104-6100
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Office: 215-746-0014
32 Fax: 215-746-0285
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32 Fax: 215-746-0285
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Publications
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Education:
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6b Aristotelian University of Thessaloniki - School of Medicine, Thessaloniki, Greece, 1991.
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21 9 M.D. c
6b Aristotelian University of Thessaloniki - School of Medicine, Thessaloniki, Greece, 1991.
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Links
81 Search PubMed for articles
57 Lab Website
6f ResearchGate
7f Primary Work Website
84 Pathology Website
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Permanent link81 Search PubMed for articles
57 Lab Website
6f ResearchGate
7f Primary Work Website
84 Pathology Website
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42 RNA dysregulation in the pathogenesis of neurodegeneration
3c RNA-based therapeutics for neurodegenerative diseases
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1d Medical Neuropathology
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2a Fellowship Director, Neuropathology
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Description of Research Expertise
6f Biology of Ribonucleoproteins (RNPs) composed of small RNAs (siRNAs, miRNAs, piRNAs) and mRNAs42 RNA dysregulation in the pathogenesis of neurodegeneration
3c RNA-based therapeutics for neurodegenerative diseases
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Description of Clinical Expertise
68 Surgical Neuropathology (Brain tumors; Brain biopsies; Muscle biopsies; Nerve biopsies)1d Medical Neuropathology
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Description of Other Expertise
35 Director, Division of Neuropathology2a Fellowship Director, Neuropathology
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e2 Liu X, Jin D-Y, McManus MT, Mourelatos Z: Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell 46(4): 507-17, May 2012.
7c Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z b2 : Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol 19(8): 773-81, Aug 2012.
133 Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ: Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity. J Neurol Sci 301(1-2): 112-5, Feb 2011.
2a7 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD: A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci USA 108(52): 20881-90, Dec 2011.
13d Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Priti L: MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathol 22(4): 522-9, Jul 2012.
f1 Kirino Y, Vourekas A, Khandros E, Mourelatos Z: Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Mol Biol 725: 281-93, 2011.
12e de Planell-Saguer M, Rodicio MC, Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nat Protoc 5(6): 1061-73, May 2010.
e2 Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z: Arginine methylation of vasa protein is conserved across phyla. J Biol Chem 30 285(11): 8148-54, Mar 2010.
97 Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z 91 : Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA 16(1): 70-8, Jan 2010.
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Selected Publications
224 Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee V-MY, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD: Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Molec Genet 21(13): 2899-911, Jul 2012.e2 Liu X, Jin D-Y, McManus MT, Mourelatos Z: Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell 46(4): 507-17, May 2012.
7c Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z b2 : Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis. Nat Struct Mol Biol 19(8): 773-81, Aug 2012.
133 Venneti S, Moss HE, Levin MH, Vagefi MR, Brozena CS, Pruitt AA, Mourelatos Z, Trojanowski JQ, Galetta SL, Balcer LJ: Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity. J Neurol Sci 301(1-2): 112-5, Feb 2011.
2a7 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD: A yeast functional screen predicts new candidate ALS disease genes. Proc Natl Acad Sci USA 108(52): 20881-90, Dec 2011.
13d Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Priti L: MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. Brain Pathol 22(4): 522-9, Jul 2012.
f1 Kirino Y, Vourekas A, Khandros E, Mourelatos Z: Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs. Methods Mol Biol 725: 281-93, 2011.
12e de Planell-Saguer M, Rodicio MC, Mourelatos Z: Rapid in situ codetection of noncoding RNAs and proteins in cells and formalin-fixed paraffin-embedded tissue sections without protease treatment. Nat Protoc 5(6): 1061-73, May 2010.
e2 Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z: Arginine methylation of vasa protein is conserved across phyla. J Biol Chem 30 285(11): 8148-54, Mar 2010.
97 Kirino A, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z 91 : Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization. RNA 16(1): 70-8, Jan 2010.
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