Faculty

Michael Guo, MD, PhD

Assistant Professor of Neurology

Department: Neurology

Graduate Group Affiliations

Contact information

3400 Spruce Street
3 Gates Building
Philadelphia, PA 19104

Education
BS (Cellular and Molecular Biology)
University of Michigan--Ann Arbor, 2010.
PhD (Genetics and Genomics)
Harvard University, 2016.
MD
University of Florida, 2018.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Alzheimer's disease
frontotemporal dementia
neurodegeneration
neurogenetics

Description of Research Expertise

genetics
human genetics
genomics
somatic mosaicism
complex trait genetics
Mendelian genetics
transcriptomics
Alzheimer's disease
neurodegeneration

Selected Publications

Lee S, Hamdan Z, Huntress SS, Yang A, Guo MH: A large-scale single cell map of primary and conditional regulatory variation in the human brain. medRxiv June 2026.

Ho C-H, Dippel MA, McQuade MS, Mishra A, Pribitzer S, Nguyen LA, Hardy S, Chandok H, Chardon F, McDiarmid TA, DeBerg HA, Buckner JH, Shendure J, de Boer CG, Guo MH, Tewhey R, Ray JP: Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cells. Nature Genetics 57(10), Oct 2025.

Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins J.: Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease. Nature Communications 16(1), Jan 2025.

Gibson AW, Elser H, Rosso M, Cornblath EJ, Fonkeu Y, Prasad S, Rothstein A, Nasrallah IM, Wolk DA, Guo MH : Ischemic stroke associated with amyloid-related imaging abnormalities in a patient treated with lecanemab. Alzheimer's & Dementia 20(11): 8192-8197, Nov 2024.

Baldwin A, Copeland J, Azage M, Dratch L, Johnson K, Paul RA, Amado DA, Baer M, Deik A, Elman LB, Guo M, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn CC, Tropea TF, Scherer SS, Shinohara RT, Hamilton RH, Ellis CA.: Disparities in Genetic Testing for Neurologic Disorders. Neurology 102(6): e209161, Mar 2024.

Dratch L, Bardakjian TM, Johnson K, Babaian N, Gonzalez-Alegre P, Elman L, Quinn C, Guo MH, Scherer SS, Amado DA.: The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics. Biology 13(2): 93, Feb 2024.

Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA.: Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurol 271(2): 733-747, Feb 2024.

Guo MH, Francioli LC, Stenton SL, Goodrich JK, Watts NA, Singer-Berk M, Groopman E, Darnowsky PW, Solomonson M, Baxter S; gnomAD Project Consortium; Tiao G, Neale BM, Hirschhorn JN, Rehm HL, Daly MJ, O'Donnell-Luria A, Karczewski KJ, MacArthur DG, Samocha KE.: Inferring compound heterozygosity from large-scale exome sequencing data. Nat Genet 56(1): 152-161, Jan 2024.

Lofrano-Porto A, Pereira SA, Dauber A, Bloom JC, Fontes AN, Asimow N, de Moraes OL, Araujo PAT, Abreu AP, Guo MH, De Oliveira SF, Liu H, Lee C, Kuohung W, Coelho MS, Carroll RS, Jiang R, Kaiser UB.: OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. J Clin Invest 133(23): e161701, Dec 2023.

Deignan JL, Gregg AR, Grody WW, Guo MH, Kearney H, Monaghan KG, Raraigh KS, Taylor J, Zepeda-Mendoza CJ, Ziats C; ACMG Board of Directors.: Updated recommendations for CFTR carrier screening: A position statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med 25(8): 100867, Aug 2023.