Faculty

Mohammad Haj Dezfulian, PhD

Assistant Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact information

Email:
mohammad.hajdezfulian@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
B.Sc. (Molecular Biology and Genetics)
Tehran University & Chamran University, 2006.
PhD (Molecular Biology and Genetics)
University of Windsor, 2014.

Links
Search PubMed for articles
Haj-Dezfulian Lab Website
Department of Pathology and Laboratory Medicine Profile
The Institute for Immunology and Immune Health Profile

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Our laboratory investigates the molecular drivers of immune recognition across autoimmunity, malignancy, and infectious disease. We combine systems immunology with functional genomics and protein engineering to develop high-throughput technologies capable of mapping T cell specificity within patient samples. This engineering-driven approach enables us to elucidate the governing principles of immune specificity and tolerance, ultimately guiding the design of novel immunotherapeutic modalities.

Selected Publications

Kohlgruber AC, Dezfulian MH, Sie B, Wang CI, Kula T, Laserson U, Larman HB, Elledge SJ.: High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits. Nat Biotechnol no volume(no issue), July 2024 Notes: https://doi.org/10.1038/s41587-024-02248-6.

Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. : TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell 186(25): 5569-5586.e21, December 2023 Notes: doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27.

Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.: T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 178(4): 1016-1028.e13, August 2019 Notes: doi: 10.1016/j.cell.2019.07.009.