Faculty

Katherine Uyhazi, MD, PhD

Assistant Professor of Ophthalmology

Department: Ophthalmology

Graduate Group Affiliations

Contact information

Stellar Chance Laboratories, Rm 313A
422 Curie Blvd
Philadelphia, PA 19104

Office: (215) 662-8816

Email:
katherine.uyhazi@pennmedicine.upenn.edu

Education:
B.S (Biology)
The College of New Jersey, 2005.
M.D/Ph.D. (Cell Biology)
Yale School of Medicine, 2013.

Links
Uyhazi Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Inherited retinal degenerations
Retinitis pigmentosa
Stargardt disease
Cone rod dystrophy
Leber congenital amaurosis
Gyrate atrophy
Electroretinography (ERG)
Genetic testing

Description of Research Expertise

Retinal gene therapy
Stem cell therapy
Retinal regeneration
Photoreceptor development
Subretinal injections
Induced Pluripotent Stem Cells (iPSCs)
Murine models of eye disease
Single cell RNA sequencing (scRNAseq)
Retinal histology

Selected Publications

Oertel FC, Cabrera Debuc D, Calabresi PA, Chen M, Cordano C, Dietrich M, Feltgen N, Gramlich O, Green AJ, Groh J, Huang SC, Knier B, Korn T, Leocani L, Loewenstein A, van Oterendorp C, Peto T, Schippling S, Schmetterer L, Schmitz-Valckenberg S, Seeliger MW, Shindler KS, Schuman JS, Sindi M, Tufail A, Wang JK, Wolf S, You Y, Zinkernagel M, Lagrèze W, Albrecht P; IMSVISUAL consortium.: APOSTEL-R Recommendations for Reporting Retinal Optical Coherence Tomography Studies in Rodents. Neurol Neuroimmunol Neuroinflamm. Published online ahead of print. In press, Nov 2025 Notes: Listed in Co-investigator Appendix for participating in questionnaires regarding retinal OCT measurements in rodents.

Aleman TS, Uyhazi KE, Roman AJ, Weber ML, O'Neil EC, Swider M, Sumaroka A, Maguire KH, Aleman EM, Santos AJ, Kim RJ, Parchinski KM, Billek A, Fradin M, Chung W, Margaritis P, Sun J, Scoles DH, Wu V, Garafalo AV, Jayagopal A, Yerxa B, Tuller S, Maguire AM, Bennett J, Cideciyan AV.: Recovery of cone-mediated vision in Lebercilin associated retinal ciliopathy after gene therapy: One-year results of a phase I/II trial. Mol Ther 33: 4784-4798, Oct 2025.

Pham K, Uyhazi KE.: Retinal Findings in Kjellin Syndrome. Ophthalmology Aug 2025 Notes: In press; published online ahead of print.

Wilder RJ, An AF, Bell BA, Fossett G, Wojciechowski AM, Shpylchak I, Uyhazi KE.: Intraretinal variation in disease severity in the Oat(rhg) mouse model of gyrate atrophy. Exp Eye Res 255: 110382, June 2025.

Yano JJ, Wei Z, Bell BA, Uyhazi KE: Lineage Tracing of Photoreceptor Precursor Cell Subpopulations During Murine Retinal Development. 20th International Congress of Developmental Biology / Society for Developmental Biology 84th Annual Meeting (San Juan, Puerto Rico) 2025 Notes: Poster.

Yano JJ, Wei Z, Bell BA, Uyhazi KE.: Lineage Tracing of Photoreceptor Precursor Cell Subpopulations During Murine Retinal Development. 2025 Mid-Atlantic Society for Developmental Biology (SDB) Regional Meeting (Richmond, VA). 2025 Notes: Oral presentation.

Aleman TS, Cideciyan AV, Uyhazi KE, Weber ML, Roman AJ, Swider M, Sumaroka A, Maguire KH, Aleman EM, O'Neil EC, Santos A, Kim RJ, Parchinski KM, Fradin M, Chung W, Margaritis P, Sun J, Scoles DH, Wu V, Garafalo AV, Jayagopal A, Yerxa B, Tuller S, Maguire AM, Bennett J.: Recovery of Cone-Mediated Vision in a Severe Ciliopathy after Gene Augmentation One Year Results of a Phase I/II Trial for LCA5-LCA. Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting (Salt Lake City, UT) 2025.

Passino R, Bell B, Uyhazi KE: Microglia Inhibition Improves Gene Therapy in a Mouse Model of Photoreceptor Degeneration. 152nd Anniversary Meeting of the Scheie Eye Institute (Philadelphia, PA) 2025 Notes: Poster.

Yano JJ, Wei Z, Uyhazi KE: Lineage Tracing Photoreceptor Precursor Cells During Murine Retinal Development. Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting (Salt Lake City, UT) 2025 Notes: Poster.

Yano JJ, Wei Z, Uyhazi KE: Lineage Tracing Photoreceptor Precursor Cells During Murine Retinal Development. 152nd Anniversary Meeting of the Scheie Eye Institute. (Philadelphia, PA) 2025 Notes: Poster.