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Nilam S. Mangalmurti, MD
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Associate Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania
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Attending Physician, Hospital of University of Pennsylvania
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Member, Lung Biology Institute
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Member, Institute for Immunology
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Full Member (Research) Immunobiology Research Program, Abramson Cancer Center
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Department: Medicine
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Graduate Group Affiliations
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- Bioengineering e
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Contact information
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Stemmler Hall
35 3450 Hamilton Walk
Philadelphia, PA 19104
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35 3450 Hamilton Walk
Philadelphia, PA 19104
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Office: 2155739918
30 Fax: 2155734469
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30 Fax: 2155734469
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Education:
21 7 BA 2c (Biology and South Asian Studies) c
33 University of Pennsylvania, 1998.
21 7 MD 15 (Medicine) c
3d Temple University School of Medicine, 2002.
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Permanent link21 7 BA 2c (Biology and South Asian Studies) c
33 University of Pennsylvania, 1998.
21 7 MD 15 (Medicine) c
3d Temple University School of Medicine, 2002.
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Description of Clinical Expertise
136 Dr. Mangalmurti serves as an attending physician for the Medical Intensive Care Unit and the Procedure and Resuscitation Service at the Hospital of the University of Pennsylvania. Dr. Mangalmurti’s clinical interests include acute lung injury and the management of the critically ill patient.71
Description of Research Expertise
475 I am a physician-scientist with a clinical practice in critical care, and a research program focused on syndromes affecting the critically ill. These syndromes include sepsis, the dysregulated host response to infection, and ARDS, Acute Respiratory Distress Syndrome. A comprehensive mechanistic understanding of the host response during sepsis is imperative because the aberrant host response rather than the pathogen itself often drives organ failure and mortality. While other enucleate cells such as platelets play a vital role in innate immunity, astonishingly little is known about RBC immune function. RBCs are the most abundant circulating cell in the body and have a tremendous capacity to modulate inflammatory responses due to their large surface area and constant contact with circulating pathogen and host-derived inflammatory mediators. My lab's overarching long-term objective is to define RBCs' immunomodulatory functions that may alter the immune response to pathogens and sterile injury. My lab has two broad, but related themes focused on innate immunity and inflammation in the vascular compartment.e 29
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204 L.K. Metthew Lam , Sophia Murphy, Dimitra Kokkinaki, Alessandro Venosa, Scott Sherrill-Mix, Carla Casu, Stefano Rivella, Aaron Weiner, Jeongho Park, Sunny Shin, Andrew Vaughan, Beatrice H. Hahn, Audrey R. Odom John, Nuala J. Meyer, Christopher A. Hunter, G. Scott Worthen, Nilam S. Mangalmurti: DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Science Translational Medicine 13(616), October 2021.
173 Yehya N, Booth TJ, Ardhanari GD, Thompson JM, Lam LKM, Till JE, Mai MV, Keim G, McKeone DJ, Halstead ES, Lahni P, Varisco BM, Zhou W, Carpenter EL, Christie JD, Mangalmurti NS.: Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome. J Clin Invest Apr 2024.
13a Metthew Lam LK, Oatman E, Eckart KA, Klingensmith NJ, Flowers E, Sayegh L, Yuen J, Clements RL, Meyer NJ, Jurado KA, Vaughan AE, Eisenbarth SC, Mangalmurti NS: Human red blood cells express the RNA sensor TLR7. Scientific Reports July 2024.
11f Thompson JC, Li S, Jose JS, Predina J, Gupta A, Eruslanov E, Singhal S, Albelda SM, Mangalmurti NS.: Red blood cells function as reservoirs of tumor DNA. Am J Physiol Lung Cell Mol Physiol 326: L646-L650, May 2024.
1bc Meghan J. Hotz, Danielle Qing, Michael G. S. Shashaty, Peggy Zhang, Hilary Faust, Neal Sondheimer, Stefano Rivella, G. Scott Worthen, and Nilam S. Mangalmurti : Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury. American Journal of Respiratory and Critical Care Medicine 197(4): 470-480, February 2018.
175 Qing D,Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation. American Journal of Respiratory and Critical Care Medicine 190(11): 1243-54, December 2014.
158 L K Metthew Lam, Jane Dobkin, Kaitlyn A Eckart, Ian Gereg, Andrew DiSalvo, Amber Nolder, Eman Anis , Julie C Ellis, Greg Turner, Nilam S Mangalmurti : Bat Red Blood Cells Express Nucleic Acid-Sensing Receptors and Bind RNA and DNA. Immunohorizons 6(5): 299-306, May 2022.
2a6 Michael G. S. Shashaty, MD, MSCE; John P. Reilly, M.D., M.S.C.E.; Hilary E. Faust, M.D.; Caitlin M. Forker, B.A.; Caroline A. G. Ittner, Ph.D.; Peggy X. Zhang, B.S.; Meghan J. Hotz, B.S.; David Fitzgerald; Wei Yang, Ph.D.; Brian J. Anderson, M.D., M.S.C.E.; Daniel N. Holena, MD, MSCE; Paul N. Lanken, M.D., M.S.C.E.; Jason D. Christie, M.D., M.S.C.E.; Nuala J. Meyer, MD, MS; Nilam S. Mangalmurti, M.D.: Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study. Critical Care 23(1): 235 published on-line, June 2019.
170 Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113(5): 1158-66, Jan 2009.
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Selected Publications
1a6 L K Metthew Lam , Nathan J Klingensmith , Layal Sayegh , Emily Oatman , Joshua S Jose , Christopher V Cosgriff , Kaitlyn A Eckart , John McGinnis , Piyush Ranjan , Matthew Lanza , Nadir Yehya , Nuala J Meyer , Robert P Dickson , Nilam S Mangalmurti : Red Blood Cells Capture and Deliver Bacterial DNA to Drive Host Responses During Polymicrobial Sepsis. J Clin Invest 28 135, December 2024.204 L.K. Metthew Lam , Sophia Murphy, Dimitra Kokkinaki, Alessandro Venosa, Scott Sherrill-Mix, Carla Casu, Stefano Rivella, Aaron Weiner, Jeongho Park, Sunny Shin, Andrew Vaughan, Beatrice H. Hahn, Audrey R. Odom John, Nuala J. Meyer, Christopher A. Hunter, G. Scott Worthen, Nilam S. Mangalmurti: DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Science Translational Medicine 13(616), October 2021.
173 Yehya N, Booth TJ, Ardhanari GD, Thompson JM, Lam LKM, Till JE, Mai MV, Keim G, McKeone DJ, Halstead ES, Lahni P, Varisco BM, Zhou W, Carpenter EL, Christie JD, Mangalmurti NS.: Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome. J Clin Invest Apr 2024.
13a Metthew Lam LK, Oatman E, Eckart KA, Klingensmith NJ, Flowers E, Sayegh L, Yuen J, Clements RL, Meyer NJ, Jurado KA, Vaughan AE, Eisenbarth SC, Mangalmurti NS: Human red blood cells express the RNA sensor TLR7. Scientific Reports July 2024.
11f Thompson JC, Li S, Jose JS, Predina J, Gupta A, Eruslanov E, Singhal S, Albelda SM, Mangalmurti NS.: Red blood cells function as reservoirs of tumor DNA. Am J Physiol Lung Cell Mol Physiol 326: L646-L650, May 2024.
1bc Meghan J. Hotz, Danielle Qing, Michael G. S. Shashaty, Peggy Zhang, Hilary Faust, Neal Sondheimer, Stefano Rivella, G. Scott Worthen, and Nilam S. Mangalmurti : Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury. American Journal of Respiratory and Critical Care Medicine 197(4): 470-480, February 2018.
175 Qing D,Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS.: Red Blood Cells Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation. American Journal of Respiratory and Critical Care Medicine 190(11): 1243-54, December 2014.
158 L K Metthew Lam, Jane Dobkin, Kaitlyn A Eckart, Ian Gereg, Andrew DiSalvo, Amber Nolder, Eman Anis , Julie C Ellis, Greg Turner, Nilam S Mangalmurti : Bat Red Blood Cells Express Nucleic Acid-Sensing Receptors and Bind RNA and DNA. Immunohorizons 6(5): 299-306, May 2022.
2a6 Michael G. S. Shashaty, MD, MSCE; John P. Reilly, M.D., M.S.C.E.; Hilary E. Faust, M.D.; Caitlin M. Forker, B.A.; Caroline A. G. Ittner, Ph.D.; Peggy X. Zhang, B.S.; Meghan J. Hotz, B.S.; David Fitzgerald; Wei Yang, Ph.D.; Brian J. Anderson, M.D., M.S.C.E.; Daniel N. Holena, MD, MSCE; Paul N. Lanken, M.D., M.S.C.E.; Jason D. Christie, M.D., M.S.C.E.; Nuala J. Meyer, MD, MS; Nilam S. Mangalmurti, M.D.: Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study. Critical Care 23(1): 235 published on-line, June 2019.
170 Mangalmurti Nilam S, Xiong Zeyu, Hulver Mei, Ranganathan Mrunalini, Liu Xiang Hong, Oriss Timothy, Fitzpatrick Meghan, Rubin Marc, Triulzi Darrell, Choi Augustine, Lee Janet S: Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood 113(5): 1158-66, Jan 2009.
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