1e
19
1
49
2
2
18
1b
1d
18
30
98
1d
2 29
1d
25
Ryan M Carey, M.D.
78
98
Assistant Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania
28
84
3
81
Attending Surgeon, University of Pennsylvania Health System, Philadelphia, PA
8a
Attending Surgeon, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
98
Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
97
Member, Abramson Cancer Center, University of Pennsylvania, Cancer Therapeutics Research Program
11
Department: Otorhinolaryngology: Head and Neck Surgery
4
1
b
1d
46
Contact information
5e
4
3
3
1d
5e
Department of Otolaryngology-Head & Neck Surgery
22 University of Pennsylvania
3f 3400 Spruce Street, 5 Ravdin
Philadelphia, PA 19104
26
22 University of Pennsylvania
3f 3400 Spruce Street, 5 Ravdin
Philadelphia, PA 19104
35
f
18
Publications
23 a
3
2
29
4
b
1f
23 a
13
Education:
21 c B.S.E. 1b (Bioengineering) c
70 University of Pennsylvania School of Engineering and Applied Sciences, Philadelphia, PA, 2013.
21 9 M.D. 15 (Medicine) c
68 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2017.
c
3
3
3
3
8d
Permanent link21 c B.S.E. 1b (Bioengineering) c
70 University of Pennsylvania School of Engineering and Applied Sciences, Philadelphia, PA, 2013.
21 9 M.D. 15 (Medicine) c
68 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2017.
c
2 29
21
1e
1d
24
5e
71
8
153 Dr. Carey is the sponsor-investigator for “A Phase I Randomized Controlled Trial of Intratumoral Lidocaine Injection Before Transoral Robotic Surgery (TORS) and Neck Dissection for HPV-Associated Oropharyngeal Squamous Cell Carcinoma.” NCT06747390. More information is available at: https://clinicaltrials.gov/study/NCT06747390
8
67 Additional information about the Carey lab is available at: https://www.med.upenn.edu/carey-lab/
e 29
27
Description of Clinical Expertise
166 Dr. Carey provides advanced medical and surgical head and neck cancer care and reconstructive services to patients at the Hospital of the University of Pennsylvania and the Veteran’s Administration Medical Center. He specializes in head and neck oncologic surgery, transoral robotic surgery (TORS), and microvascular reconstructive surgery.71
Description of Research Expertise
2c8 Dr. Carey is a surgeon-scientist engaged in research aimed at improving the diagnosis and treatment of head and neck cancer. He runs a cancer neuroscience lab that investigates how head and neck cancer cells interact with the local tumor environment. His lab is specifically focused on G-protein coupled receptors including taste receptors and how the involved signaling pathways can regulate important cellular processes in head and neck cancer. The goal is to leverage taste receptors as biomarkers or therapeutic targets for treating malignancies. His group is actively translating their basic science findings from bench to bedside through clinical trials on therapies developed in the lab.8
153 Dr. Carey is the sponsor-investigator for “A Phase I Randomized Controlled Trial of Intratumoral Lidocaine Injection Before Transoral Robotic Surgery (TORS) and Neck Dissection for HPV-Associated Oropharyngeal Squamous Cell Carcinoma.” NCT06747390. More information is available at: https://clinicaltrials.gov/study/NCT06747390
8
67 Additional information about the Carey lab is available at: https://www.med.upenn.edu/carey-lab/
e 29
23
138 94. Sywanycz SM, Hill BL, Miller ZA, Turner G, Huang L, Polen K, Lee RJ, Carey RM: T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma. Molecular Cancer Therapeutics November 2025.
114 Kaki PC, Patel AM, Huang L, Turner G, Haleem A, Brant JA, Brody RM, Carey RM: Treatment of Biopsy-Proven Laryngeal Squamous Cell Carcinoma in Situ. Laryngoscope Investigative Otolaryngology October 2025.
105 Turner G, Sywanycz SM, Buchler BL, Wardlow RD, Lee RJ, Carey RM: Quercetin as a Bitter Taste Receptor Agonist with Anticancer Effects in Head and Neck Cancer Cells. Nutrients October 2025.
144 Kaki PC, Lam D, Sangal NR, Carey RM, Rajasekaran K, Chalian A, Brody RM, Weinstein GS, Cannady SB: Comparing Functional Outcomes Following TORS with Free Flap Reconstruction Using a Radial Forearm vs Anterolateral Thigh Flap. Head Neck September 2025.
e7 Huang L, Patel AM, Chao T Carey RM: Robotic Resection of Parapharyngeal Follicular Dendritic Cell Sarcoma with Castleman Disease. Laryngoscope September 2025.
111 Hoerter JE, Eide JG, Salmon M, Carey RM, Prasad A, Brant JA, Palmer JN, Adappa ND, Kshirsagar RS: Nodal Metastasis in Surgically Treated Sinonasal Squamous Cell Carcinoma. Discover Oncology July 2025.
115 Sangal NR, Tapescu I, Kaki PC, Brody RM, Carey RM: Outcomes of Immunotherapy Utilization in Distantly Metastatic Head and Neck Squamous Cell Carcinoma. JAMA Otolaryngology-Head and Neck Surgery June 2025.
125 Kaki PC, Haleem A, Kaki PC, Lee JJ, Maxwell R, Brant JA, Brody RM, Carey RM: Adjuvant radiotherapy in pT3–4N0M0 major salivary gland cancer without other adverse features. American Journal of Otolaryngology April 2025.
104 Kaki PC, Patel AM, Choudhry HS, Brant JA, Brody RM, Carey RM: Elective neck dissection in cT1-4 N0M0 head and neck spindle cell carcinoma. Otolaryngology-Head and Neck Surgery April 2025.
2c
7
1d
1f
Selected Publications
20f Wang SY, Turner G, Valdes-Morales KL, Hunter ER, Kim M, Tran VA, Polen K, Haynes D, Miller CJ, Etzkorn JR, Sobanko JF, Walker JL, Zhang J, Brody RM, Cannady SB, Rajasekaran K, Farwell DG, Miura JT, Karakousis GC, Lukens JR, Amaravadi RK, Schuchter LM, Mitchell TC, Higgins HW II, Carey RM: Accuracy of Sentinel Lymph Node Biopsy in Head and Neck Merkel Cell Carcinoma: Predictors of Biopsy Failure and Nodal Metastasis. JAMA Otolaryngology November 2025.138 94. Sywanycz SM, Hill BL, Miller ZA, Turner G, Huang L, Polen K, Lee RJ, Carey RM: T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma. Molecular Cancer Therapeutics November 2025.
114 Kaki PC, Patel AM, Huang L, Turner G, Haleem A, Brant JA, Brody RM, Carey RM: Treatment of Biopsy-Proven Laryngeal Squamous Cell Carcinoma in Situ. Laryngoscope Investigative Otolaryngology October 2025.
105 Turner G, Sywanycz SM, Buchler BL, Wardlow RD, Lee RJ, Carey RM: Quercetin as a Bitter Taste Receptor Agonist with Anticancer Effects in Head and Neck Cancer Cells. Nutrients October 2025.
144 Kaki PC, Lam D, Sangal NR, Carey RM, Rajasekaran K, Chalian A, Brody RM, Weinstein GS, Cannady SB: Comparing Functional Outcomes Following TORS with Free Flap Reconstruction Using a Radial Forearm vs Anterolateral Thigh Flap. Head Neck September 2025.
e7 Huang L, Patel AM, Chao T Carey RM: Robotic Resection of Parapharyngeal Follicular Dendritic Cell Sarcoma with Castleman Disease. Laryngoscope September 2025.
111 Hoerter JE, Eide JG, Salmon M, Carey RM, Prasad A, Brant JA, Palmer JN, Adappa ND, Kshirsagar RS: Nodal Metastasis in Surgically Treated Sinonasal Squamous Cell Carcinoma. Discover Oncology July 2025.
115 Sangal NR, Tapescu I, Kaki PC, Brody RM, Carey RM: Outcomes of Immunotherapy Utilization in Distantly Metastatic Head and Neck Squamous Cell Carcinoma. JAMA Otolaryngology-Head and Neck Surgery June 2025.
125 Kaki PC, Haleem A, Kaki PC, Lee JJ, Maxwell R, Brant JA, Brody RM, Carey RM: Adjuvant radiotherapy in pT3–4N0M0 major salivary gland cancer without other adverse features. American Journal of Otolaryngology April 2025.
104 Kaki PC, Patel AM, Choudhry HS, Brant JA, Brody RM, Carey RM: Elective neck dissection in cT1-4 N0M0 head and neck spindle cell carcinoma. Otolaryngology-Head and Neck Surgery April 2025.
2c