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Haineng Xu, Ph.D.
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Research Assistant Professor of Obstetrics and Gynecology
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Department: Obstetrics and Gynecology
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Contact information
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Ovarian Cancer Research Center, University of Pennsylvania
5c 421 Curie Blvd., Biomedical Research Building II/III 1214
Philadelphia, PA 19104
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5c 421 Curie Blvd., Biomedical Research Building II/III 1214
Philadelphia, PA 19104
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Office: 832-705-3657
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Publications
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Links
b4 Search PubMed for articles
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Education:
21 d Bachelor 1a (Biotechnology) c
30 Anhui Normal University, 2007.
21 a Ph.D. 1b (Cancer Biology) c
34 Chinese Academy of Sciences, 2013.
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Permanent link21 d Bachelor 1a (Biotechnology) c
30 Anhui Normal University, 2007.
21 a Ph.D. 1b (Cancer Biology) c
34 Chinese Academy of Sciences, 2013.
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161 Duan H, Xie Y, Wu S, Zhao G, Zeng Z, Hu H, Yu Y, Hu W, Yang Y, Chen Y, Xie H, Chen Z, Zhang G, Flaherty KT, Hu S, Xu H*, Ma W*, Mou Y* (* Equal Contribution): Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma. J Transl Med 22(1): 880, Sep 2024.
1e0 Xu H#, Gitto SB#, Ho GY#, Medvedev S, Shield-Artin K, Kim H, Beard S, Kinose Y, Wang X, Barker HE, Ratnayake G, Hwang WT, Australian Ovarian Cancer Study, Hansen RJ, Strouse B, Milutinovic S, Hassig C, Wakefield MJ, Vandenberg CJ*, Scott CL*, Simpkins F* (# Equal Contribution): CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer. iScience 27(7):109978, May 2024.
1ab Gitto SB, Whicker M, Davies G, Kumar S, Kinneer K, Xu H, Lewis A, Mamidi S, Medvedev S, Kim H, Anderton J, Tang EJ, Ferman B, Coats S, Wilkinson RW, Brown E, Powell DJ, Simpkins F: A B7-H4 targeting antibody-drug conjugate shows anti-tumor activity in PARPi and platinum resistant cancers with B7-H4 expression. Clin Cancer Res 30(8):1567-1581, Apr 2024.
1f6 Kinose Y#, Xu H#, Kim H, Kumar S, Shan X, George E, Wang X, Medvedev S, Ferman B, Gitto SB, Whicker M, D'Andrea K, Wubbenhorst B, Hallberg D, O'Connor M, Schwartz LE, Hwang WT, Nathanson KL, Mills GB, Velculescu VE, Wang TL, Brown EJ, Drapkin R, Simpkins F (# Equal Contribution): Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer. Research Square [preprint] rs.3.rs-3314138, Sep 2023.
1dc Xu H#, George E#, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F (# Equal Contribution): CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med 2(9): 100394, 2021.
1c8 Kim H#, Xu H#, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F (# Equal Contribution): Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun 11(1): 3726, 2020.
15d Gitto SB, Kim H, Rafail S, Omran DK, Medvedev S, Kinose Y, Rodriguez-Garcia A, Flowers AJ, Xu H, Schwartz LE, Powell DJ Jr, Simpkins F: An autologous humanized patient-derived-xenograft platform to evaluate immunotherapy in ovarian cancer. Gynecol Oncol 156(1): 222-232, 2020.
15e Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2alpha. Nat Commun 9(1): 559, 2018.
145 Liu T#, Xu H#, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O'Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y (# Equal Contribution): Circulating Glioma Cells Exhibit Stem Cell-like Properties. Cancer Res 78(23): 6632-6642, 2018.
157 Liu T#, Ma W#, Xu H#, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y (# Equal Contribution): PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nat Commun 9(1): 3439, 2018.
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Selected Publications
1bd Xu H#, George E#, Gallo D#, Medvedev S, Wang X, Datta A, Kryczka R, Hyer ML, Fourtounis J, Stocco R, Aguado-Fraile E, Petrone A, Yin SY, Shiwram A, Liu F, Anderson M, Kim H, Greenberg RA, Marshall CG, Simpkins F. (# Equal contribution): Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR. Nat Commun 16(1): 3112, April 2025.161 Duan H, Xie Y, Wu S, Zhao G, Zeng Z, Hu H, Yu Y, Hu W, Yang Y, Chen Y, Xie H, Chen Z, Zhang G, Flaherty KT, Hu S, Xu H*, Ma W*, Mou Y* (* Equal Contribution): Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma. J Transl Med 22(1): 880, Sep 2024.
1e0 Xu H#, Gitto SB#, Ho GY#, Medvedev S, Shield-Artin K, Kim H, Beard S, Kinose Y, Wang X, Barker HE, Ratnayake G, Hwang WT, Australian Ovarian Cancer Study, Hansen RJ, Strouse B, Milutinovic S, Hassig C, Wakefield MJ, Vandenberg CJ*, Scott CL*, Simpkins F* (# Equal Contribution): CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer. iScience 27(7):109978, May 2024.
1ab Gitto SB, Whicker M, Davies G, Kumar S, Kinneer K, Xu H, Lewis A, Mamidi S, Medvedev S, Kim H, Anderton J, Tang EJ, Ferman B, Coats S, Wilkinson RW, Brown E, Powell DJ, Simpkins F: A B7-H4 targeting antibody-drug conjugate shows anti-tumor activity in PARPi and platinum resistant cancers with B7-H4 expression. Clin Cancer Res 30(8):1567-1581, Apr 2024.
1f6 Kinose Y#, Xu H#, Kim H, Kumar S, Shan X, George E, Wang X, Medvedev S, Ferman B, Gitto SB, Whicker M, D'Andrea K, Wubbenhorst B, Hallberg D, O'Connor M, Schwartz LE, Hwang WT, Nathanson KL, Mills GB, Velculescu VE, Wang TL, Brown EJ, Drapkin R, Simpkins F (# Equal Contribution): Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer. Research Square [preprint] rs.3.rs-3314138, Sep 2023.
1dc Xu H#, George E#, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F (# Equal Contribution): CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med 2(9): 100394, 2021.
1c8 Kim H#, Xu H#, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F (# Equal Contribution): Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun 11(1): 3726, 2020.
15d Gitto SB, Kim H, Rafail S, Omran DK, Medvedev S, Kinose Y, Rodriguez-Garcia A, Flowers AJ, Xu H, Schwartz LE, Powell DJ Jr, Simpkins F: An autologous humanized patient-derived-xenograft platform to evaluate immunotherapy in ovarian cancer. Gynecol Oncol 156(1): 222-232, 2020.
15e Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2alpha. Nat Commun 9(1): 559, 2018.
145 Liu T#, Xu H#, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O'Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y (# Equal Contribution): Circulating Glioma Cells Exhibit Stem Cell-like Properties. Cancer Res 78(23): 6632-6642, 2018.
157 Liu T#, Ma W#, Xu H#, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y (# Equal Contribution): PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nat Commun 9(1): 3439, 2018.
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