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Golnaz Vahedi, Ph.D.
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Professor of Genetics
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Member, Abramson Cancer Center, Penn Medicine
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Member, Institute for Diabetes, Obesity and Metabolism Institute, Penn Medicine
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Deputy Director, Institute for Immunology & Immune Health, Penn Medicine
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Co-Director, Penn Epigenetics Institute, Penn Medicine
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Department: Genetics
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Graduate Group Affiliations
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Contact information
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314 BRB II/III
36 421 Curie Boulevard
Philadelphia, PA 19104
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36 421 Curie Boulevard
Philadelphia, PA 19104
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Publications
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Education:
21 a B.Sc. 23 (Electrical Engineering) c
38 Sharif University of Technology, 2001.
21 a M.Sc. 23 (Electrical Engineering) c
36 University of Alberta, Canada, 2005.
21 a Ph.D. 23 (Electrical Engineering) c
34 Texas A&M University, Texas, 2009.
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Permanent link21 a B.Sc. 23 (Electrical Engineering) c
38 Sharif University of Technology, 2001.
21 a M.Sc. 23 (Electrical Engineering) c
36 University of Alberta, Canada, 2005.
21 a Ph.D. 23 (Electrical Engineering) c
34 Texas A&M University, Texas, 2009.
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Description of Research Expertise
347 The overarching goal of the Vahedi laboratory is to understand the molecular mechanisms through which genomic information in our immune cells is interpreted in normal development and further dissect how common genetic variation can lead to misinterpretation of the genetic material in immune mediated diseases. The multidisciplinary nature of our laboratory allows us to exploit cutting-edge computational and experimental approaches and generate unbiased maps of genome organization in primary immune cells in humans and mice. We further follow our hypothesis-generating yet unbiased efforts with experiments dissecting the mechanisms of our predictions using genome editing in mice or cell lines which provides us with an unparalleled opportunity to rigorously define the link between genetics and chromatin organization.e 29
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c6 Jay, A., Pondevida, C.M. and Vahedi, G.: The epigenetic landscape of fate decisions in T cells. Nature Immunology March 2025.
171 Patil, A.R., Schug, J., Liu, C., Lahori, D., Descamps, H.C., the Human Pancreas Analysis Consortium, Naji, A., Kaestner, K.H., Faryabi, R.B., Vahedi, G.: Modeling Type 1 Diabetes progression from single-cell transcriptomic measurements in human islets. Cell Reports Medicine 21: 101535, May 2024.
f8 Goldman N., Chandra A., Johnson I., Sullivan M.A., Patil A.R., Vanderbeck A., Jay A., Zhou Y., Ferrari E.K., Mayne L., Aguilan J., Xue H.H., Faryabi R.B., Wherry E.J., Sidoli S., Maillard I. and Vahedi G. bc : Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity. Nature Immunology 24: 1698-1710, October 2023.
e5 Chandra# A., Yoon# S., Michieletto# M.F., Goldman N., Ferrari E.K., Abedi M., Johnson I., Fasolino M., Pham K., Joannas L., Kee B.L., Henao-Mejia* J, and Vahedi* G., #co-first authors, e8 *co-corresponding authors: Quantitative control of Ets1 dosage through a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation. Immunity 58: 1451-1467, July 2023.
14e Wang# W., Chandra# A., Goldman# N., Yoon# S., Ferrari# E.K., Nguyen S.C., Joyce E.F., Vahedi G., #co-first authors: TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. Nature Immunology 23: 1052-1062, July 2022.
f9 Yoon, S., Chandra, A. and Vahedi, G.: Stripenn detects architectural stripes from chromatin conformation data using computer vision. Nature Communications 13: 1602, March 2022.
211 Fasolino M., Schwartz G.W., Patil A.R., Mongia A., Golson M.L., Wang Y.J., Morgan A., Liu C., Schug J., Liu J., Wu M., Traum D., Kondo A., May C.L., Goldman N., Wang W., Feldman M., Moore J.H., Japp A.S., Betts M.R.; HPAP Consortium, Faryabi R.B., Naji A., Kaestner K.H., Vahedi G.: Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in Type 1 Diabetes. Nature Metabolism 4: 284-299, February 2022 Notes: Cited > 135.
16e Fasolino M., Goldman N., Wang W., Cattau B., Zhou Y., Petrovic J., Link V.M., Cote A., Chandra A., Silverman M., Joyce E.F., Little S.C., the HPAP Consortium, Kaestner K.H., Naji A., Raj A., Henao-Mejia J., Faryabi R.B., and Vahedi G.: Genetic Variation in Type 1 Diabetes Reconfigure the 3D Chromatin Organization ab of T Cells. Immunity. Cell Press, 52(2): 257-274, February 2020 Notes: Featured on journal's cover. Highlighted on Spotlight in Trends Immunology.
1a2 Johnson J.L., Georgakilas G., Petrovic J., Kurachi M., Cai S., Harly C., Pear W.S., Bhandoola A., Wherry E.J., Vahedi G.: Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells. Immunity. Cell Press, 48(2): 243-257, February 2018 Notes: Featured on journal's cover and received a News and Views. Cited > 222.
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Selected Publications
1c1 Abedi, M., Rai, P., Zhou, Y., Liu, C., Johnson, I., Chandra, A., Fasolino, M., Rostami, S., Wang, W., Min, Z., Li, Y., Yu, M., Jay, A., Lian, V., Silverman, M., Kaestner, K. H., Naji, A., Faryabi, R. B., Vahedi, G.: Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens of human Type 1 Diabetes. Science Immunology November 2025.c6 Jay, A., Pondevida, C.M. and Vahedi, G.: The epigenetic landscape of fate decisions in T cells. Nature Immunology March 2025.
171 Patil, A.R., Schug, J., Liu, C., Lahori, D., Descamps, H.C., the Human Pancreas Analysis Consortium, Naji, A., Kaestner, K.H., Faryabi, R.B., Vahedi, G.: Modeling Type 1 Diabetes progression from single-cell transcriptomic measurements in human islets. Cell Reports Medicine 21: 101535, May 2024.
f8 Goldman N., Chandra A., Johnson I., Sullivan M.A., Patil A.R., Vanderbeck A., Jay A., Zhou Y., Ferrari E.K., Mayne L., Aguilan J., Xue H.H., Faryabi R.B., Wherry E.J., Sidoli S., Maillard I. and Vahedi G. bc : Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity. Nature Immunology 24: 1698-1710, October 2023.
e5 Chandra# A., Yoon# S., Michieletto# M.F., Goldman N., Ferrari E.K., Abedi M., Johnson I., Fasolino M., Pham K., Joannas L., Kee B.L., Henao-Mejia* J, and Vahedi* G., #co-first authors, e8 *co-corresponding authors: Quantitative control of Ets1 dosage through a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation. Immunity 58: 1451-1467, July 2023.
14e Wang# W., Chandra# A., Goldman# N., Yoon# S., Ferrari# E.K., Nguyen S.C., Joyce E.F., Vahedi G., #co-first authors: TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. Nature Immunology 23: 1052-1062, July 2022.
f9 Yoon, S., Chandra, A. and Vahedi, G.: Stripenn detects architectural stripes from chromatin conformation data using computer vision. Nature Communications 13: 1602, March 2022.
211 Fasolino M., Schwartz G.W., Patil A.R., Mongia A., Golson M.L., Wang Y.J., Morgan A., Liu C., Schug J., Liu J., Wu M., Traum D., Kondo A., May C.L., Goldman N., Wang W., Feldman M., Moore J.H., Japp A.S., Betts M.R.; HPAP Consortium, Faryabi R.B., Naji A., Kaestner K.H., Vahedi G.: Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in Type 1 Diabetes. Nature Metabolism 4: 284-299, February 2022 Notes: Cited > 135.
16e Fasolino M., Goldman N., Wang W., Cattau B., Zhou Y., Petrovic J., Link V.M., Cote A., Chandra A., Silverman M., Joyce E.F., Little S.C., the HPAP Consortium, Kaestner K.H., Naji A., Raj A., Henao-Mejia J., Faryabi R.B., and Vahedi G.: Genetic Variation in Type 1 Diabetes Reconfigure the 3D Chromatin Organization ab of T Cells. Immunity. Cell Press, 52(2): 257-274, February 2020 Notes: Featured on journal's cover. Highlighted on Spotlight in Trends Immunology.
1a2 Johnson J.L., Georgakilas G., Petrovic J., Kurachi M., Cai S., Harly C., Pear W.S., Bhandoola A., Wherry E.J., Vahedi G.: Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells. Immunity. Cell Press, 48(2): 243-257, February 2018 Notes: Featured on journal's cover and received a News and Views. Cited > 222.
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