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Jonathan P. Katz, MD
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Associate Professor of Medicine (Gastroenterology)
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Director, Undergraduate Student Scholars Program, University of Pennsylvania Perelman School of Medicine
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Director, Molecular Pathology and Imaging Core, NIH Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania Perelman School of Medicine
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Member, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine
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Member, Penn Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine
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Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine
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Co-Director, Graduate Training in Medical Sciences, University of Pennsylvania Perelman School of Medicine
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Director, NIDDK - Medical Student Research Training Program (MSRT), University of Pennsylvania Perelman School of Medicine
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Director, Penn GI T32 Basic Science Training Grant, University of Pennsylvania Perelman School of Medicine
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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421 Curie Boulevard
4f 913 Biomedical Research Building II/III
Philadelphia, PA 19104-4863
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4f 913 Biomedical Research Building II/III
Philadelphia, PA 19104-4863
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Office: 215-746-7780
32 Fax: 215-573-2024
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32 Fax: 215-573-2024
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Email:
jpkatz@mail.med.upenn.edu
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jpkatz@mail.med.upenn.edu
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Publications
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Links
ca Search PubMed for articles
7c CAMB Faculty Page
54 Center for Molecular Studies in Digestive and Liver Diseases
5e Krüppel-Like Factors Website
f7 University of Pennsylvania Perelman School of Medicine Center for Molecular Studies in Digestive and Liver Diseases Undergraduate Student Scholars Program
7e Gastroenterology Division
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ca Search PubMed for articles
7c CAMB Faculty Page
54 Center for Molecular Studies in Digestive and Liver Diseases
5e Krüppel-Like Factors Website
f7 University of Pennsylvania Perelman School of Medicine Center for Molecular Studies in Digestive and Liver Diseases Undergraduate Student Scholars Program
7e Gastroenterology Division
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Education:
21 9 A.B. 16 (Chemistry) c
3f Columbia University, Columbia College , 1988.
21 9 M.D. c
4b University of Chicago, Pritzker School of Medicine, 1993.
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Permanent link21 9 A.B. 16 (Chemistry) c
3f Columbia University, Columbia College , 1988.
21 9 M.D. c
4b University of Chicago, Pritzker School of Medicine, 1993.
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22 Transcriptional regulation
1e Epithelial homeostasis
27 Gastrointestinal carcinogenesis
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68 Key words: gastrointestinal cancer, Krüppel-like factors, proliferation, differentiation
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26 Description of Research
4a9 Our research is focused broadly on functional analyses of gastrointestinal epithelial proliferation, differentiation, and carcinogenesis, using both in vivo and in vitro approaches, including murine models and innovative three-dimensional tissue culture systems. To dissect the critical pathways regulating gastrointestinal epithelial homeostasis and disease, we have focused predominantly on the roles of two critical transcriptional regulators in the Krüppel-like factor (KLF) family of proteins, KLF4 and KLF5, with a particular focus on the biology of the squamous-lined esophagus. Both KLF4 and KLF5 have been implicated in key cellular process such differentiation, inflammation, stemness, and carcinogenesis in a number of tissues and cell types. Current areas of investigation in our laboratory include the functional interactions between KLF4 and the non-canonical Wnt ligand WNT5A and between KLF5 and the tumor suppressor p53. Overall, these studies seek to define the specific factors which control the balance between proliferation and differentiation in gastrointestinal epithelia and the elements which disrupt this balance during mucosal injury and carcinogenesis.
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20 Rotation Projects
a1 Several rotation projects are available in the laboratory based upon applicant interests. Please contact Dr. Katz directly to discuss potential projects.
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1d Lab personnel:
34 Jonathan Katz, MD – Principal Investigator
3b Yizeng Yang, MD, PhD - Senior Research Investigator
3f Khvaramze Shaverdashvili, MD, PhD - Postdoctoral Fellow
2e Daniel Weinblatt - Research Specialist
2b Jinshen Wang, MD - Visiting Scholar
29 Divya Rao - Undergraduate Student
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28 Administrative Assistant:
15 Marielle Kent
1b Phone: 215-898-0850
28 Email: hsharpe@mail.med.upenn.edu
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Description of Research Expertise
2a Research Interests22 Transcriptional regulation
1e Epithelial homeostasis
27 Gastrointestinal carcinogenesis
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68 Key words: gastrointestinal cancer, Krüppel-like factors, proliferation, differentiation
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26 Description of Research
4a9 Our research is focused broadly on functional analyses of gastrointestinal epithelial proliferation, differentiation, and carcinogenesis, using both in vivo and in vitro approaches, including murine models and innovative three-dimensional tissue culture systems. To dissect the critical pathways regulating gastrointestinal epithelial homeostasis and disease, we have focused predominantly on the roles of two critical transcriptional regulators in the Krüppel-like factor (KLF) family of proteins, KLF4 and KLF5, with a particular focus on the biology of the squamous-lined esophagus. Both KLF4 and KLF5 have been implicated in key cellular process such differentiation, inflammation, stemness, and carcinogenesis in a number of tissues and cell types. Current areas of investigation in our laboratory include the functional interactions between KLF4 and the non-canonical Wnt ligand WNT5A and between KLF5 and the tumor suppressor p53. Overall, these studies seek to define the specific factors which control the balance between proliferation and differentiation in gastrointestinal epithelia and the elements which disrupt this balance during mucosal injury and carcinogenesis.
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20 Rotation Projects
a1 Several rotation projects are available in the laboratory based upon applicant interests. Please contact Dr. Katz directly to discuss potential projects.
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1d Lab personnel:
34 Jonathan Katz, MD – Principal Investigator
3b Yizeng Yang, MD, PhD - Senior Research Investigator
3f Khvaramze Shaverdashvili, MD, PhD - Postdoctoral Fellow
2e Daniel Weinblatt - Research Specialist
2b Jinshen Wang, MD - Visiting Scholar
29 Divya Rao - Undergraduate Student
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28 Administrative Assistant:
15 Marielle Kent
1b Phone: 215-898-0850
28 Email: hsharpe@mail.med.upenn.edu
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113 Tarapore, R.S., Yang, Y., Katz, J.P.: Restoring KLF5 in Esophageal Squamous Cell Cancer Cells Activates the JNK Pathway Leading to Apoptosis and Reduced Cell Survival. Neoplasia 15(5): 472-80, May 2013.
118 Yang, Y., Tarapore, R.S., Jarmel, M.H., Tetreault, M.P., Katz, J.P.: p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle 11(21): 4033-9, Sep 2012.
103 Tetreault, M.P., Alrabaa, R., McGeehan, M., Katz, J.P. : Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One 7(5): e38338, May 2012.
158 Yang, Y., Nakagawa, H., Tetreault, M.P., Billig, J., Victor, N., Goyal, A., Sepulveda, A.R., Katz, J.P.: Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Research 71(20): 6475-84, Oct 2011.
14f Tetreault, M.P., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Tobias, J.W., Katz, J.P.: Esophageal squamous cell dysplasia and delayed differentiation with deletion of Krüppel-like factor 4 in murine esophagus. Gastroenterology 139(1): 171-81.e9, Jul 2010.
14a Tetreault, M.P., Wang, M.L., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Katz, J.P.: Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology 139(6): 2124-2134.e9, Dec 2010.
123 Yang, Y., Tetreault, M.P., Yermolina, Y., Goldstein, B.G., Katz, J.P.: Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. Journal of Biological Chemistry 283(27): 18812-20, Jul 2008.
106 Yang, Y., Goldstein, B.G., Nakagawa, H., Katz, J.P.: Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB Journal 21(2): 543-50, Feb 2007.
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Selected Publications
bf Tetreault, M.P., Yang, Y., Katz, J.P: Krüppel-like factors in cancer. Nature Reviews Cancer 13(10): 701-13, Oct 2013.113 Tarapore, R.S., Yang, Y., Katz, J.P.: Restoring KLF5 in Esophageal Squamous Cell Cancer Cells Activates the JNK Pathway Leading to Apoptosis and Reduced Cell Survival. Neoplasia 15(5): 472-80, May 2013.
118 Yang, Y., Tarapore, R.S., Jarmel, M.H., Tetreault, M.P., Katz, J.P.: p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle 11(21): 4033-9, Sep 2012.
103 Tetreault, M.P., Alrabaa, R., McGeehan, M., Katz, J.P. : Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One 7(5): e38338, May 2012.
158 Yang, Y., Nakagawa, H., Tetreault, M.P., Billig, J., Victor, N., Goyal, A., Sepulveda, A.R., Katz, J.P.: Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Research 71(20): 6475-84, Oct 2011.
14f Tetreault, M.P., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Tobias, J.W., Katz, J.P.: Esophageal squamous cell dysplasia and delayed differentiation with deletion of Krüppel-like factor 4 in murine esophagus. Gastroenterology 139(1): 171-81.e9, Jul 2010.
14a Tetreault, M.P., Wang, M.L., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Katz, J.P.: Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology 139(6): 2124-2134.e9, Dec 2010.
123 Yang, Y., Tetreault, M.P., Yermolina, Y., Goldstein, B.G., Katz, J.P.: Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. Journal of Biological Chemistry 283(27): 18812-20, Jul 2008.
106 Yang, Y., Goldstein, B.G., Nakagawa, H., Katz, J.P.: Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB Journal 21(2): 543-50, Feb 2007.
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