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Gregory R. Bowman, PhD
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Louis Heyman University Professor
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Department: Biochemistry and Biophysics
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Graduate Group Affiliations
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Contact information
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422 Curie Blvd.
43 Stellar-Chance Bldg., 1009A
Philadelphia, PA 19104-6059
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43 Stellar-Chance Bldg., 1009A
Philadelphia, PA 19104-6059
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Email:
grbowman@seas.upenn.edu
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grbowman@seas.upenn.edu
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Publications
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Links
b1 Search PubMed for articles
96 Folding@home distributed computing project, which I serve as Director for
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b1 Search PubMed for articles
96 Folding@home distributed computing project, which I serve as Director for
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Education:
21 7 BS 3b (Computer Science, minor Biomedical Engineering) c
2b Cornell University, 2006.
21 a Ph.D. 17 (Biophysics) c
2c Stanford University, 2010.
21 c Certif. 1c (Mentor Training) c
33 University of Pennsylvania, 2022.
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Permanent link21 7 BS 3b (Computer Science, minor Biomedical Engineering) c
2b Cornell University, 2006.
21 a Ph.D. 17 (Biophysics) c
2c Stanford University, 2010.
21 c Certif. 1c (Mentor Training) c
33 University of Pennsylvania, 2022.
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311 Jansen J, Reimer KC, Nagai JS, Varghese FS, Overheul GJ, de Beer M, Roverts R, Daviran D, Fermin LAS, Willemsen B, Beukenboom M, Djudjaj S, von Stillfried S, van Eijk LE, Mastik M, Bulthuis M, Dunnen WD, van Goor H, Hillebrands JL, Triana SH, Alexandrov T, Timm MC, van den Berge BT, van den Broek M, Nlandu Q, Heijnert J, Bindels EMJ, Hoogenboezem RM, Mooren F, Kuppe C, Miesen P, Grünberg K, Ijzermans T, Steenbergen EJ, Czogalla J, Schreuder MF, Sommerdijk N, Akiva A, Boor P, Puelles VG, Floege J, Huber TB; COVID Moonshot consortium, van Rij RP, Costa IG, Schneider RK, Smeets B, Kramann R.: SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. Cell Stem Cell 29: 217-231, Feb 2022.
eb Topf M, Rosta E, Bowman GR, Bonomi M.: Editorial: Experiments and Simulations: A Pas de Deux to Unravel Biological Function. Front Mol Biosci 8: 799406, Nov 2021.
139 Knoverek CR, Mallimadugula UL, Singh S, Rennella E, Frederick TE, Yuwen T, Raavicharla S, Kay LE, Bowman GR.: Opening of a cryptic pocket in β-lactamase increases penicillinase activity. Proc Natl Acad Sci U S A 118: e2106473118, Nov 2021.
15e Malik M, Ward MD, Fang Y, Porter JR, Zimmerman MI, Koelblen T, Roh M, Frolova AI, Burris TP, Bowman GR, Imoukhuede PI, England SK.: Naturally Occurring Genetic Variants in the Oxytocin Receptor Alter Receptor Signaling Profiles. ACS Pharmacol Transl Sci 4: 1543-1555, Sep 2021.
11e Vithani N, Ward MD, Zimmerman MI, Novak B, Borowsky JH, Singh S, Bowman GR.: SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential. Biophys J 120: 2880-2889, Jul 2021.
128 Ward MD, Zimmerman MI, Meller A, Chung M, Swamidass SJ, Bowman GR.: Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets. Nat Commun 12: 3023, May 2021.
168 Cubuk J, Alston JJ, Incicco JJ, Singh S, Stuchell-Brereton MD, Ward MD, Zimmerman MI, Vithani N, Griffith D, Wagoner JA, Bowman GR, Hall KB, Soranno A, Holehouse AS.: The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA. Nat Commun 12: 1936, Mar 2021.
1a6 Zimmerman MI, Porter JR, Ward MD, Singh S, Vithani N, Meller A, Mallimadugula UL, Kuhn CE, Borowsky JH, Wiewiora RP, Hurley MFD, Harbison AM, Fogarty CA, Coffland JE, Fadda E, Voelz VA, Chodera JD, Bowman GR.: SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome. Nat Chem 13: 651–659, 2021.
13d Kshirsagar M, Tasnina N, Ward MD, Law JN, Murali TM, Lavista Ferres JM, Bowman GR, Klein-Seetharaman J.: Protein sequence models for prediction and comparative analysis of the SARS-CoV-2 -human interactome. Pac Symp Biocomput 26: 154-165, 2021.
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Selected Publications
128 Cruz MA, Frederick TE, Mallimadugula UL, Singh S, Vithani N, Zimmerman MI, Porter JR, Moeder KE, Amarasinghe GK, Bowman GR.: A cryptic pocket in Ebola VP35 allosterically controls RNA binding. Nat Commun 13: 2269, Apr 2022.311 Jansen J, Reimer KC, Nagai JS, Varghese FS, Overheul GJ, de Beer M, Roverts R, Daviran D, Fermin LAS, Willemsen B, Beukenboom M, Djudjaj S, von Stillfried S, van Eijk LE, Mastik M, Bulthuis M, Dunnen WD, van Goor H, Hillebrands JL, Triana SH, Alexandrov T, Timm MC, van den Berge BT, van den Broek M, Nlandu Q, Heijnert J, Bindels EMJ, Hoogenboezem RM, Mooren F, Kuppe C, Miesen P, Grünberg K, Ijzermans T, Steenbergen EJ, Czogalla J, Schreuder MF, Sommerdijk N, Akiva A, Boor P, Puelles VG, Floege J, Huber TB; COVID Moonshot consortium, van Rij RP, Costa IG, Schneider RK, Smeets B, Kramann R.: SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. Cell Stem Cell 29: 217-231, Feb 2022.
eb Topf M, Rosta E, Bowman GR, Bonomi M.: Editorial: Experiments and Simulations: A Pas de Deux to Unravel Biological Function. Front Mol Biosci 8: 799406, Nov 2021.
139 Knoverek CR, Mallimadugula UL, Singh S, Rennella E, Frederick TE, Yuwen T, Raavicharla S, Kay LE, Bowman GR.: Opening of a cryptic pocket in β-lactamase increases penicillinase activity. Proc Natl Acad Sci U S A 118: e2106473118, Nov 2021.
15e Malik M, Ward MD, Fang Y, Porter JR, Zimmerman MI, Koelblen T, Roh M, Frolova AI, Burris TP, Bowman GR, Imoukhuede PI, England SK.: Naturally Occurring Genetic Variants in the Oxytocin Receptor Alter Receptor Signaling Profiles. ACS Pharmacol Transl Sci 4: 1543-1555, Sep 2021.
11e Vithani N, Ward MD, Zimmerman MI, Novak B, Borowsky JH, Singh S, Bowman GR.: SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential. Biophys J 120: 2880-2889, Jul 2021.
128 Ward MD, Zimmerman MI, Meller A, Chung M, Swamidass SJ, Bowman GR.: Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets. Nat Commun 12: 3023, May 2021.
168 Cubuk J, Alston JJ, Incicco JJ, Singh S, Stuchell-Brereton MD, Ward MD, Zimmerman MI, Vithani N, Griffith D, Wagoner JA, Bowman GR, Hall KB, Soranno A, Holehouse AS.: The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA. Nat Commun 12: 1936, Mar 2021.
1a6 Zimmerman MI, Porter JR, Ward MD, Singh S, Vithani N, Meller A, Mallimadugula UL, Kuhn CE, Borowsky JH, Wiewiora RP, Hurley MFD, Harbison AM, Fogarty CA, Coffland JE, Fadda E, Voelz VA, Chodera JD, Bowman GR.: SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome. Nat Chem 13: 651–659, 2021.
13d Kshirsagar M, Tasnina N, Ward MD, Law JN, Murali TM, Lavista Ferres JM, Bowman GR, Klein-Seetharaman J.: Protein sequence models for prediction and comparative analysis of the SARS-CoV-2 -human interactome. Pac Symp Biocomput 26: 154-165, 2021.
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