1e
19
1
49
2
2
18
1b
1d
18
39
5d
1d 4 3 3 1d
2 29
1d
25
Mohammad Haj Dezfulian, PhD
88
5d
Assistant Professor of Pathology and Laboratory Medicine
28
8f
3
78
Member, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
a8
Member, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania
a7
Member, The Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania
11
Department: Pathology and Laboratory Medicine
4
1
23
1f
Graduate Group Affiliations
8
b
-
5c
- Immunology 6b
- Cell and Molecular Biology e
1d 4 3 3 1d
18
Publications
23 a
3
2
29
23 a
Links
b3 Search PubMed for articles
5d Haj-Dezfulian Lab Website
a6 Department of Pathology and Laboratory Medicine Profile b
96 The Institute for Immunology and Immune Health Profile
c
4
b
1f
b3 Search PubMed for articles
5d Haj-Dezfulian Lab Website
a6 Department of Pathology and Laboratory Medicine Profile b
96 The Institute for Immunology and Immune Health Profile
c
13
Education:
21 a B.Sc. 2b (Molecular Biology and Genetics) c
3f Tehran University & Chamran University, 2006.
21 8 PhD 2b (Molecular Biology and Genetics) c
2e University of Windsor, 2014.
c
3
3
3
3
8d
Permanent link21 a B.Sc. 2b (Molecular Biology and Genetics) c
3f Tehran University & Chamran University, 2006.
21 8 PhD 2b (Molecular Biology and Genetics) c
2e University of Windsor, 2014.
c
2 29
21
1e
1d
24
76
e 29
27
Description of Research Expertise
1dc Our research investigates the mechanisms by which human immune cells recognize antigens in autoimmunity, cancer, and infection. Integrating systems immunology, genomics, and biomolecular engineering, we design high-throughput platforms to map T cell specificity directly in patient-derived samples. This engineering-driven approach aims to decode the rules governing immune specificity and tolerance to guide the development of next-generation immunotherapies.e 29
23
1dd Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. : TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell 186(25): 5569-5586.e21, December 2023 Notes: doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27.
14e Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.: T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 178(4): 1016-1028.e13, August 2019 Notes: doi: 10.1016/j.cell.2019.07.009.
2c
7
1d
1f
Selected Publications
171 Kohlgruber AC, Dezfulian MH, Sie B, Wang CI, Kula T, Laserson U, Larman HB, Elledge SJ.: High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits. Nat Biotechnol no volume(no issue), July 2024 Notes: https://doi.org/10.1038/s41587-024-02248-6.1dd Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Farris AD, Muthuswamy SK, Warner BM, Elledge SJ. : TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell 186(25): 5569-5586.e21, December 2023 Notes: doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27.
14e Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ.: T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 178(4): 1016-1028.e13, August 2019 Notes: doi: 10.1016/j.cell.2019.07.009.
2c