Bryson W. Katona, MD/PhD
Jeffery and Cynthia King Associate Professor of Lynch Syndrome Research

- Director, Gastrointestinal Cancer Genetics Program, Penn Medicine
- Director, Gastrointestinal Cancer Risk Evaluation Program, Penn Medicine
- Member, Abramson Cancer Center - Cancer Control Program
- Director, Lynch Syndrome Program, Penn Medicine
- Member, Institute for Translational Medicine and Therapeutics - University of Pennsylvania
- Member, Center for Molecular Studies in Digestive and Liver Diseases - University of Pennsylvania
Department: Medicine
Division: Gastroenterology
Contact Information
Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
751 South Pavilion
Philadelphia, PA 19104
Office: 215-349-8222
Fax: 215-349-5915
Email: bryson.katona@pennmedicine.upenn.edu
I3H Keywords
- Cancer Immunology and Immunotherapy
Publications
Links
Education
-
BA (Chemistry)
University of Pennsylvania, 2002 -
MS (Chemistry)
University of Pennsylvania, 2002 -
MD
Washington University in St. Louis School of Medicine, 2009 -
PhD (Biochemistry)
Washington University in St. Louis School of Medicine, 2009
Post-Graduate Training
-
Resident in Internal Medicine
University of Pennsylvania, 2009 - 2011 -
Fellow in Gastroenterology
University of Pennsylvania, 2011 - 2015
Certifications
- Board certified in Internal Medicine, 2012
- Board certified in Gastroenterology, 2014
Description of Clinical Expertise
Hereditary gastrointestinal cancer and polyposis syndromes. Gastrointestinal cancer risk evaluation.
Description of Research Expertise
Hereditary gastrointestinal cancer and polyposis syndromes, especially hereditary colorectal cancer and hereditary gastric cancer.
Selected Publications
- Fernandes CJ, Du YK, Naumer A, Kagami LA, Le A, Good M, Duvall M, Powers J, Zelley K, Maese LD, MacFarland S, Kohlmann W, Maxwell KN, Katona BW. : Pancreatic Cancer Risk and Screening Outcomes in Li-Fraumeni Syndrome Pancreas 54 : e618-e623, Aug 2025
- Bracht SA, Rong J, Gier RA, DeMarshall M, Golden H, Dhakal D, McDevitt JC, Mo F, Furth EE, Starling AS, Muir AB, Falk GW, Katona BW, Stanger BZ, Zhang NR, Shaffer SM. : Mitochondrial clone tracing within spatially intact human tissues bioRxiv Jul 2025
- Shaukat A, Burke CA, Chan AT, Grady WM, Gupta S, Katona BW, Ladabaum U, Liang PS, Liu JJ, Putcha G, Robertson DJ, Schoen RE, Meng Z, Piscitello A, Sun CK, Xu C, Lin CJ, Lee LC, Baldo L, Levin TR; PREEMPT CRC Investigators. : Clinical Validation of a Circulating Tumor DNA-Based Blood Test to Screen for Colorectal Cancer JAMA 334 : 56-63, Jul 2025
- Dudley B, Katona BW. : Improving uptake of germline genetic testing amongst individuals at high-risk of pancreatic ductal adenocarcinoma Transl Gastroenterol Hepatol 10 : 41, Jul 2025
- Palma NA, Lucas AL, Katona BW, Athanasiou A, Kureshi NM, Ford L, Keller T, Weber S, Schiess R, King T, Simeone DM, Brand R. : A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk Individuals Cancers (Basel) 17 : 1866, Jun 2025
- Katona BW, Stanich PP, Chittenden A, Hall MJ, Idos GE, Koptiuch C, Latham A, Pearlman R, Singh A, Levinson E, Dudley B. : Strategic Plan of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC): A practical roadmap to move the hereditary gastrointestinal cancer field forward Fam Cancer 24 : 51, Jun 2025
- Haider M, Masood M, Katona BW, Burke CA, Mankaney GN. : Worldwide Impact of Upper Gastrointestinal Disease in Familial Adenomatous Polyposis Diagnostics (Basel) 15 : 1218, May 2025
- Latham A, Liu YL, Constantino G, Borio M, McCoy S, Dudzik C, Heiman J, Kemel Y, Ukaegbu C, Carlo MI, Ranganathan M, Kane S, Long JM, Syngal S, Markowitz AJ, Stadler ZK, Yurgelun MB, Katona BW. : Neoplasia Detection Through Colonic Surveillance Among Young Individuals With MSH6 / PMS2 -Associated Lynch Syndrome Am J Gastroenterol Feb 2025
- Heller M, Mann DA, Katona BW. : Current Approaches of Pancreatic Cancer Surveillance in High-Risk Individuals J Gastrointest Cancer 56 : 61, Feb 2025
- Katona BW, Lubinski J, Pal T, Huzarski T, Foulkes WD, Moller P, Eisen A, Randall Armel S, Neuhausen SL, Raj R, Aeilts A, Singer CF, Bordeleau L, Karlan B, Olopade O, Tung N, Zakalik D, Kotsopoulos J, Fruscio R, Eng C, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group. : The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation Cancer 131 : e35666, Jan 2025