A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy

Li G, Sun L, Xin C, Hao T, Kharel P, Manning AC, O'Connor CL, Moore H, Lei S, Gokulnath P, Yang X, Sharma R, Garcia-Mansfield K, Pantham P, Xiao C, Wang HY, Chatterjee E, Yim S, Ren LB, Spanos M, Zhu H, Li H, Lei J, Markmann JF, Laurent LC, Rossi JJ, Akeju O, Sheng Q, Shah RV, Goddard WA 3rd, Lowe TM, Pirrotte P, Bitzer M, Ivanov P, Bonventre JV, Das S. Science. 2025 Jul 17:eadp5384. doi: 10.1126/science.adp5384. Online ahead of print. PMID: 40674449