Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo

Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2409266122. doi: 10.1073/pnas.2409266122. Epub 2025 Jul 16. PMID: 40668829 PMCID: PMC12304964